Multifunctional Oxygen-Generating Nanoflowers for Enhanced Tumor Therapy
dc.authorid | Ramalingam, Murugan/0000-0001-6498-9792 | |
dc.authorscopusid | 57223809018 | |
dc.authorscopusid | 57208173001 | |
dc.authorscopusid | 58066417300 | |
dc.authorscopusid | 58705116200 | |
dc.authorscopusid | 58705116300 | |
dc.authorscopusid | 56493479600 | |
dc.authorscopusid | 8535412500 | |
dc.authorwosid | Ramalingam, Murugan/AAV-1702-2020 | |
dc.contributor.author | Sun, Wanru | |
dc.contributor.author | Xiao, Huifang | |
dc.contributor.author | Zhu, Jiazhi | |
dc.contributor.author | Hao, Zhaokun | |
dc.contributor.author | Sun, Jian | |
dc.contributor.author | Wang, Deqiang | |
dc.contributor.author | Wang, Ranran | |
dc.date.accessioned | 2024-07-05T15:22:14Z | |
dc.date.available | 2024-07-05T15:22:14Z | |
dc.date.issued | 2023 | |
dc.department | Atılım University | en_US |
dc.department-temp | [Sun, Wanru; Zhu, Jiazhi; Hao, Zhaokun; Sun, Jian; Wang, Ranran] Binzhou Med Univ, Inst Rehabil Med, Sch Rehabil Med, Yantai 264003, Peoples R China; [Sun, Wanru; Wang, Ranran] Sci Fund Shandong Lab Adv Mat & Green Mfg Yantai, Yantai 264000, Peoples R China; [Sun, Wanru; Xie, Shuyang] Binzhou Med Univ, Key Lab Tumor Mol Biol, Yantai 264003, Peoples R China; [Xiao, Huifang] Wuhan Univ, Zhongnan Hosp, Wuhan 430062, Peoples R China; [Wang, Deqiang] Binzhou Med Univ, Yantai Affiliated Hosp, Yantai 264100, Peoples R China; [Wang, Xin] Yangzhou Univ, Clin Med Coll, Dept Rehabil Med, Yangzhou 225000, Peoples R China; [Ramalingam, Murugan] Univ Basque Country UPV EHU, Fac Pharm, Lab Pharm & Pharmaceut Technol, NanoBioCel Res Grp, Vitoria 01006, Spain; [Ramalingam, Murugan] Inst Hlth Carlos III, Networking Res Ctr Bioengn Biomat & Nanomed, Madrid 28029, Spain; [Ramalingam, Murugan] Basque Fdn Sci, IKERBASQUE, Bilbao 48013, Spain; [Ramalingam, Murugan] Univ Basque Country UPV EHU, Fac Pharm, Joint Res Lab JRL, Vitoria 01006, Spain; [Ramalingam, Murugan] Ctr Invest Biomed Red Bioingn Biomat & Nanomed CIB, Drug Formulat Unit 10, Vitoria 01006, Spain; [Ramalingam, Murugan] Ctr Invest Lascaray Ikergunea, Bioprinting & Precis Med, Ave Miguel Unamuno, Vitoria 01006, Spain; [Ramalingam, Murugan] Chengdu Univ, Sch Basic Med Sci, Chengdu 610106, Peoples R China; [Ramalingam, Murugan] Atilim Univ, Dept Met & Mat Engn, TR-06830 Ankara, Turkiye; [Ramalingam, Murugan] Med & Life Sci Fac, Inst Precis Med, D-78054 Villingen Schwennigen, Germany | en_US |
dc.description | Ramalingam, Murugan/0000-0001-6498-9792 | en_US |
dc.description.abstract | Sonodynamic therapy (SDT) and chemotherapy have received great attention as effective methods for tumor treatment. However, the inherent hypoxia of the tumor greatly hinders its therapeutic efficacy. In this work, a tumor microenvironment-responsive biodegradable nanoplatform SiO2-MnO2-PEG-Ce6&DOX (designated as SMPC&D) is fabricated by encapsulating manganese oxide (MnO2) into silica nanoparticles and anchoring poly(ethylene glycol) (PEG) onto the surface for tumor hypoxia relief and delivery, then loaded with sonosensitizer Chlorin e6 (Ce6) and chemotherapeutic drug doxorubicin (DOX) for hypoxic tumor treatment. We evaluated the physicochemical properties of SMPC&D nanoparticles and the tumor therapeutic effects of chemotherapy and SDT under ultrasound stimulation in vitro and in vivo. After endocytosis by tumor cells, highly expressed glutathione (GSH) triggers biodegradation of the nanoplatform and MnO2 catalyzes hydrogen peroxide (H2O2) to generate oxygen (O-2), thereby alleviating tumor hypoxia. Depleting GSH and self-supplying O-2 effectively improve the SDT efficiency both in vitro and in vivo. Ultrasonic stimulation promoted the release and cellular uptake of chemotherapy drugs. In addition, the relieved hypoxia reduced the efflux of chemotherapy drugs by downregulating the expression of the P-gp protein, which jointly improved the effect of chemotherapy. This study demonstrates that the degradable SMPC&D as a therapeutic agent can achieve efficient chemotherapy and SDT synergistic therapy for hypoxic tumors. | en_US |
dc.description.sponsorship | Department of Science and Technology of Shandong Province [2022KJ091]; Education Department of Shandong Province [51903015, 81772281]; National Natural Science Foundation of China [AMGM2021F03, AMGM2023F16]; Science Fund of Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai [202220010527]; Shandong Province Medical Health Science And Technology Development Plan Project [ZR2022LSW002, ZR2020KH015]; Shandong Science and Technology Committee [50012304274]; Scientific Research Foundation of Binzhou Medical University [ts201712067]; Shandong Province Taishan Scholar Project [YZ2022203]; ICTS "NANBIOSIS", Yangzhou Science and Technology Development Plan Project; Nanomedicine (CIBER-BBN) at the University of the Basque | en_US |
dc.description.sponsorship | This work was supported by the Education Department of Shandong Province (No. 2022KJ091), the National Natural Science Foundation of China (Grant Nos. 51903015 and 81772281), the Science Fund of Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai (AMGM2021F03 and AMGM2023F16), the Shandong Province Medical Health Science And Technology Development Plan Project (No. 202220010527), the Shandong Science and Technology Committee (Nos. ZR2022LSW002 and ZR2020KH015), the Scientific Research Foundation of Binzhou Medical University (No. 50012304274), the Shandong Province Taishan Scholar Project (No. ts201712067), the ICTS "NANBIOSIS", Yangzhou Science and Technology Development Plan Project (YZ2022203), and in particular by the Drug Formulation Unit (U10) of the CIBER in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) at the University of the Basque. | en_US |
dc.identifier.citation | 2 | |
dc.identifier.doi | 10.1021/acsabm.3c00678 | |
dc.identifier.endpage | 5008 | en_US |
dc.identifier.issn | 2576-6422 | |
dc.identifier.issue | 11 | en_US |
dc.identifier.pmid | 37880964 | |
dc.identifier.scopus | 2-s2.0-85177498558 | |
dc.identifier.startpage | 4998 | en_US |
dc.identifier.uri | https://doi.org/10.1021/acsabm.3c00678 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14411/2149 | |
dc.identifier.volume | 6 | en_US |
dc.identifier.wos | WOS:001107602000001 | |
dc.language.iso | en | en_US |
dc.publisher | Amer Chemical Soc | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | SiO2-MnO2 nanoflowers | en_US |
dc.subject | sonodynamic therapy | en_US |
dc.subject | chemotherapy | en_US |
dc.subject | oxygen-generatingsystem | en_US |
dc.subject | hypoxic tumors | en_US |
dc.title | Multifunctional Oxygen-Generating Nanoflowers for Enhanced Tumor Therapy | en_US |
dc.type | Article | en_US |
dspace.entity.type | Publication |