Diagnostic Use of Circulating Cells and Sub-Cellular Bio-Particles

dc.authorid Tevlek, Atakan/0000-0003-0601-8642
dc.authorscopusid 57192163715
dc.contributor.author Tevlek, Atakan
dc.contributor.other Basic Sciences
dc.date.accessioned 2024-09-10T21:35:52Z
dc.date.available 2024-09-10T21:35:52Z
dc.date.issued 2024
dc.department Atılım University en_US
dc.department-temp [Tevlek, Atakan] Atilim Univ, Fac Med, Dept Med Biol, TR-06836 Ankara, Turkiye en_US
dc.description Tevlek, Atakan/0000-0003-0601-8642 en_US
dc.description.abstract In the bloodstream or other physiological fluids, "circulating cells and sub-cellular bio-particles" include many microscopic biological elements such as circulating tumor cells (CTCs), cell-free DNA (cfDNA), exosomes, microRNAs, platelets, immune cells, and proteins are the most well-known and investigated. These structures are crucial biomarkers in healthcare and medical research for the early detection of cancer and other disorders, enabling treatment to commence before the onset of clinical symptoms and enhancing the efficacy of treatments. As the size of these biomarkers to be detected decreases and their numbers in body fluids diminishes, the detection materials, ranging from visual inspection to advanced microscopy techniques, begin to become smaller, more sensitive, faster, and more effective, thanks to developing nanotechnology. This review first defines the circulating cells and subcellular bio-particles with their biological, physical, and mechanical properties and second focuses on their diagnostic importance, including their most recent applications as biomarkers, the biosensors that are utilized to detect them, the present obstacles that must be surmounted, and prospective developments in the domain. As technology advances and biomolecular pathways are deepens, diagnostic tests will become more sensitive, specific, and thorough. Finally, integrating recent advances in the diagnostic use of circulating cells and bioparticles into clinical practice is promising for precision medicine and patient outcomes. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.citationcount 0
dc.identifier.doi 10.1016/j.pbiomolbio.2024.08.002
dc.identifier.endpage 36 en_US
dc.identifier.issn 0079-6107
dc.identifier.issn 1873-1732
dc.identifier.pmid 39159788
dc.identifier.scopus 2-s2.0-85201364525
dc.identifier.scopusquality Q2
dc.identifier.startpage 19 en_US
dc.identifier.uri https://doi.org/10.1016/j.pbiomolbio.2024.08.002
dc.identifier.volume 192 en_US
dc.identifier.wos WOS:001299209800001
dc.identifier.wosquality Q2
dc.institutionauthor Tevlek, Atakan
dc.language.iso en en_US
dc.publisher Pergamon-elsevier Science Ltd en_US
dc.relation.ispartof Progress in Biophysics and Molecular Biology en_US
dc.relation.publicationcategory Diğer en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 0
dc.subject Body fluids en_US
dc.subject Bio-particles en_US
dc.subject Biomarkers en_US
dc.subject Detection en_US
dc.subject CTCs en_US
dc.subject Diagnosis en_US
dc.subject Biosensors en_US
dc.title Diagnostic Use of Circulating Cells and Sub-Cellular Bio-Particles en_US
dc.type Review en_US
dc.wos.citedbyCount 0
dspace.entity.type Publication
relation.isAuthorOfPublication 68ede0bf-33a2-4a19-b42e-f32fb44cc083
relation.isAuthorOfPublication.latestForDiscovery 68ede0bf-33a2-4a19-b42e-f32fb44cc083
relation.isOrgUnitOfPublication c6d3b3b7-f103-4779-9789-92b2e2420f2d
relation.isOrgUnitOfPublication.latestForDiscovery c6d3b3b7-f103-4779-9789-92b2e2420f2d

Files

Original bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Diagnostic use of circulating cells and sub-cellular bio-particles.pdf
Size:
1005.57 KB
Format:
Adobe Portable Document Format

Collections