Portraying Infective Endocarditis: Results of Multinational Id-Iri Study

dc.authorid RUCH, Yvon/0000-0002-4713-9478
dc.authorid Dauby, Nicolas/0000-0002-7697-6849
dc.authorid Puca, Edmond/0000-0002-0621-4865
dc.authorid Dumitru, Irina/0000-0003-0395-6713
dc.authorid balkan, ilker inanc/0000-0002-8977-5931
dc.authorid Silva-Pinto, Andre/0000-0002-2077-3356
dc.authorid Santos, Lurdes/0000-0002-0622-6823
dc.authorscopusid 7005578733
dc.authorscopusid 54384024100
dc.authorscopusid 56653526500
dc.authorscopusid 23006157000
dc.authorscopusid 37090496300
dc.authorscopusid 26026833900
dc.authorscopusid 25622697400
dc.authorwosid RUCH, Yvon/ABF-7715-2020
dc.authorwosid Dauby, Nicolas/F-1235-2011
dc.authorwosid Florescu, Simin/AAQ-8675-2020
dc.authorwosid Puca, Edmond/AAF-7788-2020
dc.authorwosid GhanemZoubi, Nesrin/KGL-2091-2024
dc.authorwosid Dumitru, Irina/U-5493-2019
dc.authorwosid Erdem, Hakan/O-2462-2013
dc.contributor.author Erdem, Hakan
dc.contributor.author Puca, Edmond
dc.contributor.author Ruch, Yvon
dc.contributor.author Santos, Lurdes
dc.contributor.author Ghanem-Zoubi, Nesrin
dc.contributor.author Argemi, Xavier
dc.contributor.author Agalar, Canan
dc.date.accessioned 2024-07-05T15:40:22Z
dc.date.available 2024-07-05T15:40:22Z
dc.date.issued 2019
dc.department Atılım University en_US
dc.department-temp [Erdem, Hakan] IDI IRI, Ankara, Turkey; [Puca, Edmond] Univ Hosp Ctr Mother Teresa, Dept Infect Dis, Tirana, Albania; [Ruch, Yvon; Argemi, Xavier; Hansmann, Yves] Strasbourg Univ Hosp, Nouvel Hop Civil, Dept Infect Dis, Strasbourg, France; [Santos, Lurdes; Martins, Pedro Palma; Silva-Pinto, Andre; Duro, Raquel] Ctr Hosp Sao Joao, Infect Dis Dept, Porto, Portugal; [Santos, Lurdes; Martins, Pedro Palma; Silva-Pinto, Andre; Duro, Raquel] Univ Porto, Fac Med, Porto, Portugal; [Ghanem-Zoubi, Nesrin] Rambam Hlth Care Campus, Inst Infect Dis, Haifa, Israel; [Guner, Rahmet; Kaya-Kalem, Ayse; Hasanoglu, Imran] Yildirim Beyazit Univ, Dept Infect Dis & Clin Microbiol, Ataturk Training & Res Hosp, Ankara, Turkey; [Tonziello, Gilda; Petrosillo, Nicola] IRCCS, Natl Inst Infect Dis Lazzaro Spallanzani, Clin & Res Dept Infect Dis, Via Portuense 292, I-00149 Rome, Italy; [Mazzucotelli, Jean-Philippe] Strasbourg Univ Hosp, Nouvel Hop Civil, Dept Cardiovasc Surg, Strasbourg, France; [Como, Najada] UHC, Serv Infect Dis, Tirana, Albania; [Kose, Sukran] Tepecik Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey; [Batirel, Ayse] Hlth Sci Univ, Dr Lutfi Kirdar Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey; [Inan, Asuman] Haydarpasa Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey; [Tulek, Necla] Atilim Univ, Sch Med, Dept Microbiol, Ankara, Turkey; [Pekok, Abdullah Umut] Pendik Med Pk Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey; [Khan, Ejaz Ahmed] Shifa Int Hosp, Islamabad, Pakistan; [Khan, Ejaz Ahmed] Shifa Tameer e Millat Univ, Islamabad, Pakistan; [Iyisoy, Atilla] Hlth Sci Univ, Gulhane Training & Res Hosp, Dept Cardiol, Ankara, Turkey; [Meric-Koc, Meliha] Bezmialem Vakif Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey; [Oztoprak, Nefise] Hlth Sci Univ, Antalya Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Antalya, Turkey; [Almajid, Fahad] King Saud Univ Hosp, Infect Dis Div, Dept Med, Riyadh, Saudi Arabia; [Dogan, Mustafa] Corlu State Hosp, Dept Infect Dis & Clin Microbiol, Antalya, Turkey; [Dauby, Nicolas; Konopnicki, Deborah] ULB, CHU St Pierre, Dept Infect Dis, 322 Rue Haute, B-1000 Brussels, Belgium; [Gunst, Jesper Damsgaard] Aarhus Univ Hosp, Dept Infect Dis, Aarhus, Denmark; [Tekin, Recep] Dicle Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey; [Bozkurt, Ilkay] Ondokuz Mayis Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Samsun, Turkey; [Wadi, Jamal; Ajamieh, Oday Abu] Univ Jordan, Sch Med, Dept Infect Dis, Amman, Jordan; [Popescu, Corneliu; Florescu, Simin] Dr Victor Babes Clin Hosp Infect & Trop Dis, Bucharest, Romania; [Balkan, Ilker Inanc] Istanbul Univ, Cerrahpasa Med Fac, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey; [Ozer-Balin, Safak; Sagmak-Tartar, Ayse] Firat Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Elazig, Turkey; [Zupanc, Tatjana Lejko] UMC Ljubljana, Dept Infect Dis, Ljubljana, Slovenia; [Cascio, Antonio] Univ Palermo, Dept Hlth Promot Sci & Mother & Child Care G DAle, Palermo, Italy; [Dumitru, Irina Magdalena] Ovidius Univ Constanta, Clin Infect Dis Hosp, Constanta, Romania; [Erdem, Aysegul] Kecioren Training & Res Hosp, Dept Pathol, Ankara, Turkey; [Ersoz, Gulden] Mersin Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Mersin, Turkey; [Tasbakan, Meltem] Ege Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Izmir, Turkey; [Sirmatel, Fatma] Abant Izzet Baysal Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Bolu, Turkey; [Gulsun, Serda] Diyarbakir Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey; [Ozkaya, Hacer Deniz] Cigli Reg Educ Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey; [Sari, Sema] Turkey Adv Specialty Educ & Res Hosp, Dept Intens Care Unit, Ankara, Turkey; [Tosun, Selma] Izmir Bozyaka Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey; [Avci, Meltem] Usak Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Usak, Turkey; [Cag, Yasemin; Karakus, Sumeyra] Medeniyet Univ, Goztepe Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey; [Celebi, Guven] Bulent Ecevit Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Zonguldak, Turkey; [Sener, Alper] Onsekiz Mart Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Canakkale, Turkey; [Dedej, Arjeta] Amer Hosp, Dept Nephrol, Tirana, Albania; [Oncu, Serkan] Adnan Menderes Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Aydin, Turkey; [Del Vecchio, Rosa Fontana] Univ Catania, Sect Infect Dis, Dept Clin & Mol Biomed, Catania, Italy; [Ozturk-Engin, Derya; Agalar, Canan] Fatih Sultan Mehmet Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey en_US
dc.description RUCH, Yvon/0000-0002-4713-9478; Dauby, Nicolas/0000-0002-7697-6849; Puca, Edmond/0000-0002-0621-4865; Dumitru, Irina/0000-0003-0395-6713; balkan, ilker inanc/0000-0002-8977-5931; Silva-Pinto, Andre/0000-0002-2077-3356; meric koc, meliha/0000-0002-0563-6900; Ozturk-Engin, Derya/0000-0002-2566-7317; Damsgaard, Jesper/0000-0002-3787-0259; Puca, Edmond/0000-0002-0621-4865; Cag, Yasemin/0000-0002-9983-0308; Cascio, Antonio/0000-0002-1992-1796; sari, sema/0000-0002-1977-8547; Palma, Pedro/0000-0002-3698-1037; Tulek, Necla/0000-0002-3952-4982; Hasanoglu, Imran/0000-0001-6692-3893; Erdem, Hakan/0000-0002-6265-5227; ERDEM, AYSEGUL/0000-0002-5222-5928; Santos, Lurdes/0000-0002-0622-6823 en_US
dc.description.abstract Infective endocarditis is a growing problem with many shifts due to ever-increasing comorbid illnesses, invasive procedures, and increase in the elderly. We performed this multinational study to depict definite infective endocarditis. Adult patients with definite endocarditis hospitalized between January 1, 2015, and October 1, 2018, were included from 41 hospitals in 13 countries. We included microbiological features, types and severity of the disease, complications, but excluded therapeutic parameters. A total of 867 patients were included. A total of 631 (72.8%) patients had native valve endocarditis (NVE), 214 (24.7%) patients had prosthetic valve endocarditis (PVE), 21 (2.4%) patients had pacemaker lead endocarditis, and 1 patient had catheter port endocarditis. Eighteen percent of NVE patients were hospital-acquired. PVE patients were classified as early-onset in 24.9%. A total of 385 (44.4%) patients had major embolic events, most frequently to the brain (n = 227, 26.3%). Blood cultures yielded pathogens in 766 (88.4%). In 101 (11.6%) patients, blood cultures were negative. Molecular testing of vegetations disclosed pathogens in 65 cases. Overall, 795 (91.7%) endocarditis patients had any identified pathogen. Leading pathogens (Staphylococcus aureus (n = 267, 33.6%), Streptococcus viridans (n = 149, 18.7%), enterococci (n = 128, 16.1%), coagulase-negative staphylococci (n = 92, 11.6%)) displayed substantial resistance profiles. A total of 132 (15.2%) patients had cardiac abscesses; 693 (79.9%) patients had left-sided endocarditis. Aortic (n = 394, 45.4%) and mitral valves (n = 369, 42.5%) were most frequently involved. Mortality was more common in PVE than NVE (NVE (n = 101, 16%), PVE (n = 49, 22.9%), p = 0.042). en_US
dc.identifier.citationcount 26
dc.identifier.doi 10.1007/s10096-019-03607-x
dc.identifier.endpage 1763 en_US
dc.identifier.issn 0934-9723
dc.identifier.issn 1435-4373
dc.identifier.issue 9 en_US
dc.identifier.pmid 31187307
dc.identifier.scopus 2-s2.0-85067399544
dc.identifier.startpage 1753 en_US
dc.identifier.uri https://doi.org/10.1007/s10096-019-03607-x
dc.identifier.uri https://hdl.handle.net/20.500.14411/3333
dc.identifier.volume 38 en_US
dc.identifier.wos WOS:000481757500021
dc.identifier.wosquality Q2
dc.language.iso en en_US
dc.publisher Springer en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 35
dc.subject Infective endocarditis en_US
dc.subject Prosthetic en_US
dc.subject Native en_US
dc.subject S en_US
dc.subject aureus en_US
dc.subject Blood culture en_US
dc.title Portraying Infective Endocarditis: Results of Multinational Id-Iri Study en_US
dc.type Article en_US
dc.wos.citedbyCount 36
dspace.entity.type Publication

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