The Pimpled Gold Nanosphere: a Superior Candidate for Plasmonic Photothermal Therapy

dc.authorid Rabiee, Navid/0000-0002-6945-8541
dc.authorid Rabiee, Mohammad/0000-0003-1180-8729
dc.authorid Kosemehmetoglu, Kemal/0000-0002-7747-0460
dc.authorid Nasseri, Behzad/0000-0003-3634-8327
dc.authorid Kaya, Murat/0000-0002-2458-8924
dc.authorscopusid 57015072100
dc.authorscopusid 8920503400
dc.authorscopusid 9637132800
dc.authorscopusid 57206407342
dc.authorscopusid 7102340291
dc.authorscopusid 57201008317
dc.authorscopusid 57201008317
dc.authorwosid Rabiee, Navid/K-4407-2019
dc.authorwosid PİSKİN, ERHAN/G-6109-2013
dc.authorwosid Rabiee, Mohammad/L-9865-2018
dc.authorwosid Kosemehmetoglu, Kemal/A-2423-2016
dc.contributor.author Nasseri, Behzad
dc.contributor.author Turk, Mustafa
dc.contributor.author Kosemehmetoglu, Kemal
dc.contributor.author Kaya, Murat
dc.contributor.author Piskin, Erhan
dc.contributor.author Rabiee, Navid
dc.contributor.author Webster, Thomas J.
dc.contributor.other Chemical Engineering
dc.date.accessioned 2024-07-05T15:41:37Z
dc.date.available 2024-07-05T15:41:37Z
dc.date.issued 2020
dc.department Atılım University en_US
dc.department-temp [Nasseri, Behzad; Piskin, Erhan] Hacettepe Univ, Chem Engn Dept, Bioengn Div, TR-06800 Ankara, Turkey; [Nasseri, Behzad; Piskin, Erhan] Hacettepe Univ, Bioengn Ctr, TR-06800 Ankara, Turkey; [Nasseri, Behzad; Kaya, Murat] Atilim Univ, Chem Engn & Appl Chem Dept, TR-06830 Ankara, Turkey; [Nasseri, Behzad] Shahid Beheshti Univ, Biosci Fac, Tehran, Iran; [Turk, Mustafa] Kirikkale Univ, Bioengn Dept, Kirikkale, Turkey; [Kosemehmetoglu, Kemal] Hacettepe Med Sci Univ, Dept Pathol, Ankara, Turkey; [Rabiee, Navid] Shahid Beheshti Univ, Dept Chem, Tehran, Iran; [Webster, Thomas J.] Northeastern Univ, Dept Chem Engn, Boston, MA 02115 USA en_US
dc.description Rabiee, Navid/0000-0002-6945-8541; Rabiee, Mohammad/0000-0003-1180-8729; Kosemehmetoglu, Kemal/0000-0002-7747-0460; Nasseri, Behzad/0000-0003-3634-8327; Kaya, Murat/0000-0002-2458-8924 en_US
dc.description.abstract Background: The development of highly efficient nanoparticles to convert light to heat for anti-cancer applications is quite a challenging field of research. Methods: In this study, we synthesized unique pimpled gold nanospheres (PGNSs) for plasmonic photothermal therapy (PPTT). The light-to-heat conversion capability of PGNSs and PPTT damage at the cellular level were investigated using a tissue phantom model. The ability of PGNSs to induce robust cellular damage was studied during cytotoxicity tests on colorectal adenocarcinoma (DLD-1) and fibroblast cell lines. Further, a numerical model of plasmonic (COMSOL Multiphysics) properties was used with the PPTT experimental assays. Results: A low cytotoxic effect of thiolated polyethylene glycol (SH-PEG400-SH-) was observed which improved the biocompatibility of PGNSs to maintain 89.4% cell viability during cytometry assays (in terms of fibroblast cells for 24 hrs at a concentration of 300 mu g/mL). The heat generated from the nanoparticle-mediated phantom models resulted in Delta T=30 degrees C, Delta T=23.1 degrees C and Delta T=21 degrees C for the PGNSs, AuNRs, and AuNPs, respectively (at a 300 mu g/mL concentration and for 325 sec). For the in vitro assays of PPTT on cancer cells, the PGNS group induced a 68.78% lethality (apoptosis) on DLD-1 cells. Fluorescence microscopy results showed the destruction of cell membranes and nuclei for the PPTT group. Experiments further revealed a penetration depth of sufficient PPTT damage in a physical tumor model after hematoxylin and eosin (H&E) staining through pathological studies (at depths of 2, 3 and 4 cm). Severe structural damages were observed in the tissue model through an 808-nm laser exposed to the PGNSs. Conclusion: Collectively, such results show much promise for the use of the present PGNSs and photothermal therapy for numerous anti-cancer applications. en_US
dc.description.sponsorship Scientific and Technological Research Council of Turkey (TUBITAK) en_US
dc.description.sponsorship This study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) under the 1003 classification project. en_US
dc.identifier.citationcount 20
dc.identifier.doi 10.2147/IJN.S248327
dc.identifier.endpage 2920 en_US
dc.identifier.issn 1178-2013
dc.identifier.pmid 32425523
dc.identifier.scopus 2-s2.0-85083977009
dc.identifier.startpage 2903 en_US
dc.identifier.uri https://doi.org/10.2147/IJN.S248327
dc.identifier.uri https://hdl.handle.net/20.500.14411/3455
dc.identifier.volume 15 en_US
dc.identifier.wos WOS:000527880400001
dc.identifier.wosquality Q1
dc.institutionauthor Kaya, Murat
dc.language.iso en en_US
dc.publisher Dove Medical Press Ltd en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 27
dc.subject plasmonic en_US
dc.subject photothermal therapy en_US
dc.subject gold nanoparticles en_US
dc.subject colorectal cells en_US
dc.subject pathology en_US
dc.title The Pimpled Gold Nanosphere: a Superior Candidate for Plasmonic Photothermal Therapy en_US
dc.type Article en_US
dc.wos.citedbyCount 23
dspace.entity.type Publication
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