Real-World Data From Turkey: Is Sofosbuvir/Ledipasvir With or Without Ribavirin Treatment for Chronic Hepatitis C Really Effective?

dc.authorscopusid 7801566144
dc.authorscopusid 6603745569
dc.authorscopusid 56803372700
dc.authorscopusid 6602564624
dc.authorscopusid 55989449700
dc.authorscopusid 26025098600
dc.authorscopusid 6602089825
dc.contributor.author Demirtürk,N.
dc.contributor.author Aygen,B.
dc.contributor.author Çelik,İ.
dc.contributor.author Mıstık,R.
dc.contributor.author Akhan,S.
dc.contributor.author Barut,Ş.
dc.contributor.author Doğan,N.
dc.contributor.other Operating Room Services Program
dc.date.accessioned 2024-07-05T15:46:20Z
dc.date.available 2024-07-05T15:46:20Z
dc.date.issued 2021
dc.department Atılım University en_US
dc.department-temp Demirtürk N., Department of Infectious Disease and Clinical Microbiology, Afyon Saglik Bilimleri University, Medical Faculty, Afyonkarahisar, Turkey; Aygen B., Department of Infectious Disease and Clinical Microbiology, Erciyes University, Medical Faculty, Kayseri, Turkey; Çelik İ., Department of Infectious Diseases and Clinical Microbiology, Kayseri Education and Research Hospital, Saglik Bilimleri University, Kayseri, Turkey; Mıstık R., Infectious Disease Clinic, Medicana Hospital, Bursa, Turkey; Akhan S., Department of Infectious Disease and Clinical Microbiology, Kocaeli University, Medical Faculty, Kocaeli, Turkey; Barut Ş., Department of Infectious Disease and Clinical Microbiology, Gaziosmanpasa University, Medical Faculty, Tokat, Turkey; Ural O., Department of Infectious Disease and Clinical Microbiology, Selcuk University, Medical Faculty, Konya, Turkey; Batırel A., Department of Infectious Diseases and Clinical Microbiology, Kartal Lütfi Kırdar Education and Research Hospital, Saglik Bilimleri University, İstanbul, Turkey; Şimşek F., Department of Infectious Diseases and Clinical Microbiology, Ok Meydanı Education and Research Hospital, Saglik Bilimleri University, İstanbul, Turkey; Ersöz G., Department of Infectious Disease and Clinical Microbiology, Mersin University, Medical Faculty, Mersin, Turkey; İnan D., Department of Infectious Disease and Clinical Microbiology, Akdeniz University, Medical Faculty, Antalya, Turkey; Kınıklı S., Department of Infectious Diseases and Clinical Microbiology, Ankara Education and Research Hospital, Saglik Bilimleri University, Ankara, Turkey; Türker N., Department of Infectious Disease and Clinical Microbiology, Atatürk Education and Research Hospital, Katip Çelebi University, İzmir, Turkey; Bilgin H., Department of Infectious Disease and Clinical Microbiology, Marmara University, Medical Faculty, İstanbul, Turkey; Gürbüz Y., Department of Infectious Disease and Clinical Microbiology, Dışkapı Education and Research Hospital, University Medical Faculty, Saglik Bilimleri University, Antalya, Turkey; Tülek N., Department of Infectious Disease and Clinical Microbiology, Atılım University, Medical Faculty, Ankara, Turkey; Tarakçı H., Department of Infectious Diseases and Clinical Microbiology, Eşrefpaşa Education and Research Hospital, Saglik Bilimleri University, İzmir, Turkey; Yıldız O., Department of Infectious Disease and Clinical Microbiology, Erciyes University, Medical Faculty, Kayseri, Turkey; Türkoğlu E., Department of Infectious Disease and Clinical Microbiology, Afyon Saglik Bilimleri University, Medical Faculty, Afyonkarahisar, Turkey; Güzel D.K., Department of Infectious Diseases and Clinical Microbiology, Kayseri Education and Research Hospital, Saglik Bilimleri University, Kayseri, Turkey; Şimşek S., Department of Infectious Disease and Clinical Microbiology, Uludağ University Medical Faculty, Bursa, Turkey; Tuna N., Department of Infectious Diseases and Clinical Microbiology, Sakarya Education and Research Hospital, Saglik Bilimleri University, Sakarya, Turkey; Demir N.A., Department of Infectious Disease and Clinical Microbiology, Selcuk University, Medical Faculty, Konya, Turkey; Çağatay A., Department of Infectious Disease and Clinical Microbiology, İstanbul University, İstanbul Medical Faculty, İstanbul, Turkey; Çetinkaya R.A., Department of Infectious Diseases and Clinical Microbiology, Sultan Abdülhamid Han Education and Research Hospital, Saglik Bilimleri University, İstanbul, Turkey; Karakeçili F., Department of Infectious Diseases and Clinical Microbiology, Erzincan University, Faculty of Medicine, Erzincan, Turkey; Hakyemez İ.N., Department of Infectious Diseases and Clinical Microbiology, Bezmiâlem University, Faculty of Medicine, İstanbul, Turkey; Ertem G.T., Department of Infectious Diseases and Clinical Microbiology, Ankara Education and Research Hospital, Saglik Bilimleri University, Ankara, Turkey; Örmen B., Department of Infectious Disease and Clinical Microbiology, Atatürk Education and Research Hospital, Katip Çelebi University, İzmir, Turkey; Korkmaz P., Department of Infectious Diseases and Clinical Microbiology, Kütahya Health Sciences University, Faculty of Medicine, Kütahya, Turkey; Sili U., Department of Infectious Disease and Clinical Microbiology, Marmara University, Medical Faculty, İstanbul, Turkey; Kuruüzüm Z., Department of Infectious Disease and Clinical Microbiology, Dokuz Eylül University Faculty, İzmir, Turkey; Şener A., Department of Infectious Diseases and Clinical Microbiology, Çanakkale Onsekiz Mart University, Faculty of Medicine, Çanakkale, Turkey; Özel S.A., Department of Infectious Diseases and Clinical Microbiology, Kocaeli Training and Research Hospital, Saglik Bilimleri University, Kocaeli, Turkey; Öztürk S., Department of Infectious Diseases and Clinical Microbiology, Ümraniye Education and Research Hospital, Saglik Bilimleri University, Kocaeli, Turkey; Suer K., Department of Infectious Diseases and Clinical Microbiology, Yakın Doğu University, Faculty of Medicine, Nicosia, Turkey; Çelen M.K., Department of Infectious Diseases and Clinical Microbiology, Dicle University, Faculty of Medicine, Diyarbakır, Turkey; Konya P., Department of Infectious Disease and Clinical Microbiology, Afyon Saglik Bilimleri University, Medical Faculty, Afyonkarahisar, Turkey; Asan A., Department of Infectious Diseases and Clinical Microbiology, Bursa Yüksek İhtisas Training and Research Hospital, Saglik Bilimleri University, Bursa, Turkey; Saltoğlu N., Department of Infectious Diseases and Clinical Microbiology, İstanbul University, Cerrahpaşa Faculty of Medicine, İstanbul, Turkey; Doğan N., Department of Biostatistics and Medical Informatics, Afyon Saglik Bilimleri University, Medical Faculty, Afyonkarahisar, Turkey en_US
dc.description.abstract Background: In this study, we aimed to investigate the efficacy and safety of sofosbuvir-based therapies in the treatment of chronic hepatitis C in real-world clinical practice. Methods: Data from patients with chronic hepatitis C treated with SOF/LDV ± RBV or SOF/RBV in 31 centers across Turkey between April 1, 2017, and August 31, 2018, were recorded in a nationwide database among infectious disease specialists. Demographics, clinical, and virological outcomes were analyzed. Results: A total of 552 patients were included in the study. The mean age of the patients was 51.28 ± 14.2, and 293 (55.8%) were female. The majority had HCV genotype 1b infection (65%), 75.04% of the patients underwent treatment, and non-cirrhosis was present at baseline in 381 patients (72.6%). SOF/LDV ± RBV treatment was given to 477 patients and 48 patients received SOF/RBV according to HCV genotype. The total SVR12 rate was 99% in all patients. Five patients experienced disease relapse during the study and all of them were genotype 2. In patients infected with HCV GT2, SVR12 was 77.3%. SVR was 100% in all patients infected with other HCV genotypes. All treatments were well tolerated by patients without causing severe adverse events. Side effects and side effects-associated treatment discontinuation rates were 28.2% and 0.4%, respectively. Weakness (13.7%) was the common side effect. Conclusion: The present real-world data of 525 patients with HCV genotypes 1, 1a, 1b, 3, 4, and 5 who underwent SOF/LDV ± RBV treatment in Turkey demonstrated a high efficacy and safety profile. HCV GT2 patients should be treated with more efficacious treatment. © Copyright 2021 by The Turkish Society of Gastroenterology • Available online at turkjgastroenterol.org en_US
dc.description.sponsorship Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica, SEIMC en_US
dc.identifier.citationcount 2
dc.identifier.doi 10.5152/tjg.2020.19569
dc.identifier.endpage 163 en_US
dc.identifier.issn 1300-4948
dc.identifier.issue 2 en_US
dc.identifier.pmid PubMed:33960939
dc.identifier.scopus 2-s2.0-85106497950
dc.identifier.scopusquality Q3
dc.identifier.startpage 155 en_US
dc.identifier.trdizinid 511870
dc.identifier.uri https://doi.org/10.5152/tjg.2020.19569
dc.identifier.uri https://hdl.handle.net/20.500.14411/4045
dc.identifier.volume 32 en_US
dc.identifier.wosquality Q4
dc.institutionauthor Çelik, İrem Nur
dc.language.iso en en_US
dc.publisher AVES en_US
dc.relation.ispartof Turkish Journal of Gastroenterology en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 5
dc.subject Chronic hepatitis C en_US
dc.subject Genotype en_US
dc.subject Ledipasvir en_US
dc.subject Real-world data en_US
dc.subject Sofosbuvir en_US
dc.subject Sustained virological response en_US
dc.title Real-World Data From Turkey: Is Sofosbuvir/Ledipasvir With or Without Ribavirin Treatment for Chronic Hepatitis C Really Effective? en_US
dc.type Article en_US
dspace.entity.type Publication
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