Molecular/Antigenic Mimicry and Immunological Cross-Reactivity Explains Sars-Cov Autoimmunity

dc.authorscopusid 25642454100
dc.authorscopusid 6603843484
dc.authorscopusid 36879964800
dc.contributor.author Adiguzel, Yekbun
dc.contributor.author Bogdanos, Dimitros P.
dc.contributor.author Shoenfeld, Yehuda
dc.date.accessioned 2025-05-05T19:06:17Z
dc.date.available 2025-05-05T19:06:17Z
dc.date.issued 2025
dc.department Atılım University en_US
dc.department-temp [Adiguzel, Yekbun] Atilim Univ, Sch Med, Dept Med Biol, Ankara, Turkiye; [Bogdanos, Dimitros P.] Univ Thessaly, Fac Med, Sch Hlth Sci, Dept Rheumatol & Clin Immunol, Larisa, Greece; [Shoenfeld, Yehuda] Reichman Univ, Dina Recanati Sch Med, Herzliyya, Israel; [Shoenfeld, Yehuda] Sheba Med Ctr, Zabludowicz Ctr Autoimmune Dis, Ramat Gan, Israel en_US
dc.description.abstract COVID-19 pandemic is over, but its effects on chronic illnesses remain a challenging issue. Understanding the influence of SARS-COV-2-mediated autoimmunity and overt autoimmune disease is of paramount importance, as it can provide a critical mass of information regarding both infection-mediated (and vaccination-induced) autoimmune phenomena in susceptible individuals during the disease course, and short or long-term post-disease sequelae. The high prevalence of organ and non-organ specific autoantibody positivity in patients with COVID-19 led to studies attempting to delineate the origin and the underlying mechanism responsible for their induction nature, identifying novel autoantigens, and the self-epitope sequences which could be the impetus for the initiating autoreactive responses. Herein, we provide a meticulous review of the studies reporting those mimicking sequences that have been experimentally validated, based on the assumption that molecular mimicry and immunological crossreactivity may account for autoantibody development. Most reports are based on bioinformatics approaches, and only a disproportionally small number of studies currently demonstrate immunological crossreactivity. We took the opportunity to further review and searched for the linear human epitope sequences of human, through the epitopes deposited at the Immune Epitope Database. This included an analysis of autoimmune disease as the disease data to comprehensively understand the subject matter. The critical overview of the findings underscore the urgent and immense need for further research to gain a comprehensive understanding of the mechanisms involved and the anticipated appraisal that molecular mimicry and immunological crossreactivity is indeed central to the loss of immunological tolerance during SARS-COV-2 infection. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1016/j.autrev.2025.103811
dc.identifier.issn 1568-9972
dc.identifier.issn 1873-0183
dc.identifier.issue 7 en_US
dc.identifier.pmid 40209971
dc.identifier.scopus 2-s2.0-105002674100
dc.identifier.scopusquality Q1
dc.identifier.uri https://doi.org/10.1016/j.autrev.2025.103811
dc.identifier.volume 24 en_US
dc.identifier.wos WOS:001474058700001
dc.identifier.wosquality Q1
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 0
dc.subject Autoantibody en_US
dc.subject Autoantigen en_US
dc.subject Autoimmunity en_US
dc.subject Covid-19 en_US
dc.subject Cross-Reactivity en_US
dc.subject Sars-Cov-2 Infection en_US
dc.subject Molecular Mimicry en_US
dc.title Molecular/Antigenic Mimicry and Immunological Cross-Reactivity Explains Sars-Cov Autoimmunity en_US
dc.type Article en_US
dspace.entity.type Publication

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