Işgör, Sultan Belgin

İşgör, Sultan Belgin

Name Variants

İşgör, S. Belgin
İşgör, Sultan Belgin
İşgör,S.B.
İ.,Sultan Belgin
Isgor, S. Belgin
Isgor, S. B.
Isgor, Belgin
Isgor, BS
Isgor, B
Sultan Belgin, İşgör
Isgor S.
Isgör, B
Isgor, Belgin S.
S., Isgor
İşgör S.
S.,Işgör
Isgor, Sultan Belgin
Isgor, Belgin Sultan
Sultan Belgin, Isgor
I., Sultan Belgin
Belgin Işgör S.
İşgör B.
S.B.Isgor
Isgor,S.B.
Sultan Belgin, Işgör
İşgör B.
S. B. Isgor
S.B.Işgör
Isgor B.
S. B. Işgör
Isgor, B. S.
Işgör B.
İşgör,S.B.
İşgör, Belgin Sultan

Job Title

Profesor Doktor

Email Address

belgin.isgor@atilim.edu.tr

ORCID ID

0000-0001-5716-3159

Full item page

Scholarly Output

45

Articles

12

Citation Count

90

Supervised Theses

23 Scholarly Output Search Results

Now showing 1 - 10 of 44

Citation Count: 0
Effect of novel pp60^c-src inhibitors on mammalian glutathione S-transferase activity
(Amer Chemical Soc, 2010) Isgor, Belgin Sultan; Isgor, Yasemin Gulgun; Kilic-Kurt, Zuhal; Olgen, Sureyya; Chemical Engineering
[No Abstract Available]
Citation Count: 0
Glutathione S-Transferase inhibitory activity of novel platinum complexes with ligands of oxime derivatives
(Wiley-blackwell, 2011) Isgor, B. S.; Ozalp-Yaman, S.; Chemical Engineering
[No Abstract Available]
Citation Count: 5
THE EVALUATION OF INHIBITORY EFFECTS OF SELECTED PLANT EXTRACTS ON ANTIOXIDANT ENZYMES
(Parlar Scientific Publications (p S P), 2015) Moghaddam, Naznoosh Shomali; Isgor, Belgin S.; Isgor, Yasemin G.; Geven, Fatmagul; Yildirim, Ozlem; Chemical Engineering
Plants and most of the plant derived compounds have been known because of their potential pharmaceutical effects for a long time. They are playing an important role on the treatment of several diseases from diabetes to various types of cancers. Today most of the clinically effective pharmaceuticals are developed from plant derived ancestors in the history of medicine. In this study different parts of the plants, namely Centaurea virgata (Lam.), Cichorium intybus (L.), Euporbia macroclada (Boiss.), Melilotus of ficinalis (L.) Pall. and Zygophyllum fabago (L.) were evaluated for their potential medicinal value in terms of biological targets which are participating in antioxidant defense such as catalase (CAT), glutathione-S-transferase (GST), superoxide dismutase (SOD) and glutathione peroxidase (GPx). The results indicate that the highest total phenolic contents of leaf and flower extracts were for E. macroclada. The highest flavonoid contents are detected for the leaves of E. macroclada and Z. fabago. The evaluation of extracts against biological targets reveals that the fruit extract of Z. fabago and the flowers of C. intybus show the inhibition against GST. For CAT, the highest inhibition is observed with E. macroclada leaf extract. Among the extracts analyzed, the only but slight SOD inhibition is determined with flower part of E. macroclada.
Citation Count: 1
Diplotaxis tenuifolia ve Reseda lutea Metanol Özütünün Antioksidan Savunma Sistemi Enzimleri ve Aldoz Redüktaz Aktivitesi Üzerinde Olan Etkisinin İncelenmesi
(Turkish Pharmacists Assoc, 2018) Abdalrahman, Khalid Sharro; Güneş, Merve Gülşah; Shomalı, Naznoosh; İşgör, Belgin Sultan; Yıldırım, Özlem; Chemical Engineering
Amaç: Bu çalışmada Diplotaxis tenuifolia ve Reseda lutea’nın çiçek ve yapraklarından elde edilmiş olan metanol özütlerinin AR, CAT, GST ve GPx enzimlerinin aktiviteleri üzerinde olan etkilerinin araştırılması amaçlanmıştır. Gereç ve Yöntemler: Bu çalışmada, bitki örneklerinin toplam fenolik ve flavonoid içeriği; Folin-Ciocalteu ve alüminyum klorür reaktiflerinin yardımıyla kolorimetrik yöntemlerle değerlendirilmiştir. Ayrıca özütlerin CAT, GST, GPx ve AR enzimlerinin aktiviteleri üzerindeki etkileri kinetik analizler ile araştırılmıştır. Bulgular: En yüksek miktarda fenolik ve flavanoid içeriği sırasıyla 144.49±0.29 mg gallik asit eş değeri/L ve 250.485±0.002 quercetin eş değeri/L tespit edilmiştir. GST ve GPx için en iyi aktivite profilleri sırasıyla 121±0.05 ve 140±0.001 ng/mL IC50 değerleri ile D. tenuifolia yaprak özütünde gözlemlenmiştir. Elde edilen sonuçlara göre, R. lutea ve D. tenuifolia’nın yapraklarından elde edilen metanol özütleri, AR enzimi üzerinde önemli ölçüde bir aktivite potansiyeli göstermemiştir. Bununla beraber, çalışılmış olan çiçek ve yaprak özütlerinin hiçbiri yeterli düzeyde CAT aktivasyonu gösterememiştir. Sonuç: Çalışma sonucunda, D. tenuifolia’nın yapraklarının antioksidan enzimatik savunma sistemi üzerinde iyi bir etkiye sahip olduğu gösterilmiştir. Bu sebeple günlük diyet için iyi bir besin kaynağı olarak kabul edilebilir.
Citation Count: 1
Diversity of glutathione S-transferases in bovine liver
(Blackwell Publishing, 2005) Isgor, BS; Coruh, N; Iscan, M; Chemical Engineering
[No Abstract Available]
Citation Count: 1
Method Proposal for Distinction of Microscope Objectives on Hemocytometer Images
(Ieee, 2016) Ozkan, Akin; Isgor, S. Belgin; Sengul, Gokhan; Chemical Engineering; Computer Engineering; Department of Electrical & Electronics Engineering
Hemocytometer is a special glass plate apparatus used for cell counting that has straight lines (counting chamber) in certain size. Leveraging this special lam and microscope, a cell concentration on an available cell suspension can be estimated. The automation process of hemocytometer images will assist several research disciplines to improve consistency of results and to reduce human labor. Different objective measurements can be utilized to analyze a cell sample on microscope. These differences affect the detail of image content. Basically, while the objective value is getting increased, image scale and detail level taken from image will increase, yet visible area becomes narrower. Due to this variation, different self-cell counting approaches should be developed for images taken with different objective values. In this paper, using the hemocytometer images gathered from a microscope, a novel approach is introduced for which can estimate objective values of a microscope with machine learning methods automatically. For this purpose, a frequency-based visual feature is proposed which embraces hemocytometer structure well. As a result of the conducted tests, %100 distinction accuracy is achieved with the proposed method.
Citation Count: 1
Computer vision based automated cell counting pipeline: A case study for HL60 cancer cell on hemocytometer
(Scientific Publishers of India, 2018) Özkan,A.; İşgör,S.B.; Şengül,G.; İşgör,Y.G.; Department of Electrical & Electronics Engineering; Computer Engineering; Chemical Engineering
Counting of cells can give useful information about the cell density to understand the concerning cell culture condition. Usually, cell counting can be achieved manually with the help of the microscope and hemocytometer by the domain experts. The main drawback of the manual counting procedure is that the reliability highly depends on the experience and concentration of the examiners. Therefore, computer vision based automated cell counting is an essential tool to improve the accuracy. Although the commercial automated cell counting systems are available in the literature, their high cost limits their broader usage. In this study, we present a cell counting pipeline for light microscope images based on hemocytometer that can be easily adapted to the various cell types. The proposed method is robust to adverse image and cell culture conditions such as cell shape deformations, lightning conditions and brightness differences. In addition, we collect a novel human promyelocytic leukemia (HL60) cancer cell dataset to test our pipeline. The experimental results are presented in three measures: recall, precision and F-measure. The method reaches up to 98%, 92%, and 95% based on these three measures respectively by combining Support Vector Machine (SVM) and Histogram of Oriented Gradient (HOG). © 2018, Scientific Publishers of India. All rights reserved.
Citation Count: 0
The effect of folic acid supplementation and folate deficiency on embryo implantation
(Elsevier, 2024) Ozdemir, Elif Seda; Bulut, Deniz Irem; Saglam, Atiye Seda Yar; Isgor, Belgin; Elmas, Cigdem; Chemical Engineering
Implantation is a critical stage of pregnancy, which occurs in a short period of interaction between the receptive endometrium and the embryo. Folic acid (FA) is a synthetic derivative of folate and is recommended as a preconceptional supplement. However, the impact of different doses of FA supplementation and folate deficiency during the early stages of pregnancy requires further investigation. The aim of this study was to investigate the possible effects of FA supplementation and folate deficiency on expression of Estrogen Receptor Alpha (ER-alpha), Vascular Endothelial Growth Factor-A (VEGFA), and Integrin alpha V and beta3 (Integrin alpha V beta 3). A total of 32, 6-8-week old Wistar albino rats were divided into four groups of control, folate-deficiency, low-dose, and highdose FA supplement groups. After five weeks of FA supplementation and folate deficiency model formation, mated rats were sacrificed on the 5th gestational day (GD), and implantation sites were collected. The expression of ER- alpha, VEGFA, and Integrin alpha V beta 3 in the implantation sites were examined with immunohistochemistry and real-time PCR. The results revealed that the mRNA levels of ESR1, VEGFA, and Integrin alpha V and beta 3 were significantly increased in the high-dose FA group and significantly decreased in the folate deficiency group compared to the control group (p < 0.05). Based on these results, it can be concluded that FA supplementation before pregnancy has positive effects on the maintenance of pregnancy, and folate deficiency may lead to implantation disorders.
Citation Count: 2
Cellular Defense Enzyme Profile for Non-cytotoxic and Phenol Enriched Extracts of Heliotropium europaeum, Carlina oligocephala and Echinops ritro
(Asian Network Scientific information-ansinet, 2018) Isgor, Belgin S.; Isgor, Yasemin G.; Geven, Fatmagul; Chemical Engineering
Background and Objective:The discovery of traditional plants with some medicinal properties, verifying their biological targets and the bioassay guided standardization of their active components are the particular interest of diverse research groups recently. These efforts may help to revise the therapy modalities with natural product supplements. In this context, the possible biological targets of plants, namely Heliotropium europaeum, Carlina oligocephala and Echinops ritro, with no known medicinal value but recognized for their region specific traditional use, were evaluated. Here, the biological targets were enzymes of the antioxidant and xenobiotic defense mechanisms, with roles on inflammatory response. Materials and Methods: Cytotoxicity analyses were performed by using human promyelocytic (HL60) and chronic myelogenous leukemia (K562) cells for circulating models and breastadenocarcinoma (MCF7) cells for epithelial model to evaluate the non-toxic dose range of extracts by virtue of XTT and trypan blue. The target aimed effectiveness of these plants were determined with dose response profiles and IC50 values against glutathione peroxidase (GPX), glutathione transferase(GST),catalase (CAT) and superoxide dismutase (SOD) targets, as well as their capacity to reduce free radicals (DPPH) and non-radical hydrogen peroxide (H2O2). For standardization purposes, all extract concentrations were brought to 23.81 mg L-1 GAE and dilutions were made from these stocks. The IC50 values were determined by nonlinear regression analysis, with sigmoidal dose-response 4-parameter logistic equation. Results: The results showed that the best DPPH and H2O2 scavenging was observed with E ritro extracts. On the contrary, the best enzyme inhibition profile was observed with H europaeum against CAT, SOD, GPX and GST targets. Among the enzymes evaluated, all plants with different fractions also exerted strong GPX and CAT inhibition. Conclusion: The enzyme profiling of extracts may reveal the medicinal value of herbal remedies, by identifying their effects on cellular targets. In addition to define how reasonable the use of plants in traditional and complementary medicine (TCM) practices,these efforts may help to improve the standardized supplement preparations to benefit therapeutics with reduced efficiency due to inference with cellular defense and drug resistance enzymes, or both.
Citation Count: 53
The potential medicinal value of plants from Asteraceae family with antioxidant defense enzymes as biological targets
(Taylor & Francis Ltd, 2015) Koc, Suheda; Isgor, Belgin S.; Isgor, Yasemin G.; Moghaddam, Naznoosh Shomali; Yildirim, Ozlem; Chemical Engineering
Context: Plants and most of the plant-derived compounds have long been known for their potential pharmaceutical effects. They are well known to play an important role in the treatment of several diseases from diabetes to various types of cancers. Today most of the clinically effective pharmaceuticals are developed from plant-derived ancestors in the history of medicine. Objective: The aim of this study was to evaluate the free radical scavenging activity and total phenolic and flavonoid contents of methanol, ethanol, and acetone extracts from flowers and leaves of Onopordum acanthium L., Carduus acanthoides L., Cirsium arvense (L.) Scop., and Centaurea solstitialis L., all from the Asteraceae family, for investigating their potential medicinal values of biological targets that are participating in the antioxidant defense system such as catalase (CAT), glutathione S-transferase (GST), and glutathione peroxidase (GPx). Materials and methods: In this study, free radical scavenging activity and total phenolic and flavonoid contents of the plant samples were assayed by DPPH, Folin-Ciocalteu, and aluminum chloride colorimetric methods. Also, the effects of extracts on CAT, GST, and GPx enzyme activities were investigated. Results and discussion: The highest phenolic and flavonoid contents were detected in the acetone extract of C. acanthoides flowers, with 90.305 mg GAE/L and 185.43 mg Q/L values, respectively. The highest DPPH radical scavenging was observed with the methanol leaf extracts of C. arvense with an IC50 value of 366 ng/mL. The maximum GPx and GST enzyme inhibition activities were observed with acetone extracts from the flower of C. solstitialis with IC50 values of 79 and 232 ng/mL, respectively.

İşgör, Sultan Belgin

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Scholarly Output

45

Articles

12

Citation Count

90

Supervised Theses

23

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