Aktaş, Zeynep
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Aktaş Z.
Z., Aktaş
A., Zeynep
Aktaş,Z.
Aktas Z.
Aktaş, Zeynep
Zeynep, Aktaş
Z.,Aktas
Z.,Aktaş
Aktas, Z.
A.,Zeynep
Zeynep, Aktas
Z., Aktas
Aktas, Zeynep
Aktas,Z.
Z., Aktaş
A., Zeynep
Aktaş,Z.
Aktas Z.
Aktaş, Zeynep
Zeynep, Aktaş
Z.,Aktas
Z.,Aktaş
Aktas, Z.
A.,Zeynep
Zeynep, Aktas
Z., Aktas
Aktas, Zeynep
Aktas,Z.
Job Title
Profesor Doktor
Email Address
zeynep.aktas@atilim.edu.tr
Main Affiliation
Surgical Sciences
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Website
ORCID ID
Scopus Author ID
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID
Sustainable Development Goals
7
AFFORDABLE AND CLEAN ENERGY
1
Research Products
17
PARTNERSHIPS FOR THE GOALS
1
Research Products
Scholarly Output
16
Articles
13
Citation Count
8
Supervised Theses
0
16 results
Scholarly Output Search Results
Now showing 1 - 10 of 16
Article Citation - WoS: 3Citation - Scopus: 5Surgical Outcomes of Posterior Persistent Fetal Vasculature Syndrome: Cases With Tent-Shaped and Closed Funnel-Shaped Retinal Detachment(Springernature, 2023) Zeydanli, Ece Ozdemir; Ozdek, Sengul; Acar, Burak; Ozdemir, Huseyin Baran; Aktas, Zeynep; Gurelik, Gokhan; Atalay, Hatice Tuba; Surgical SciencesBackground/objectives To determine the role of vitreoretinal surgery (VRS) for two different forms of posterior persistent fetal vasculature syndrome (PFVS); with tent-shaped tractional retinal detachment (TRD) and closed funnel-shaped TRD. Subjects/methods Retrospective, single surgeon, consecutive case series of 52 eyes of 44 patients with posterior PFVS who underwent VRS. Cases were divided into "tent-shaped TRD" and "funnel-shaped TRD" groups based on the preoperative TRD configuration. Associated anomalies, functional and anatomical outcomes were evaluated. The cosmetic appearance was defined as poor if there was phthisis bulbi, gross buphthalmos, or corneal opacification; acceptable if there was apparent leukocoria; and excellent if none were noted at the last follow-up. Results Thirty eyes of 29 patients presented with tent-shaped TRD; 70% of which obtained counting fingers or better vision and 90% showed significant reversal of tenting achieving retinal reattachment. The cosmetic appearance was excellent in 87%. Two eyes (7%) became phthisic. Twenty-two eyes of 15 patients presented with funnel-shaped TRD and leukocoria; 45% achieved LP vision and 70% of patients with bilateral pathology had LP in at least one eye. The cosmetic appearance was acceptable to excellent in 73%. Three eyes (14%) became phthisic, one (5%) of which required enucleation. The median follow-up time was 16 (6-71) months. Conclusions VRS often provides functional vision and anatomy in posterior PFVS with tent-shaped TRD morphology. In the funnel-shaped TRD morphology, where no treatment has historically been recommended, surgery may be considered with an aim of restoring light perception and globe preservation, particularly in bilateral cases.Article Citation - WoS: 2Citation - Scopus: 4Clinical Characteristics of Patients With Intraocular Lens Calcification After Pars Plana Vitrectomy(Mdpi, 2023) Bopp, Silvia; Ozdemir, Huseyin Baran; Aktas, Zeynep; Khoramnia, Ramin; Yildirim, Timur M.; Schickhardt, Sonja; Ozdek, Sengul; Surgical SciencesAim: To determine the clinical risk factors that may increase the occurrence of intraocular lens (IOL) calcification in patients who had undergone pars plana vitrectomy (PPV). Methods: The medical records of 14 patients who underwent IOL explantation due to clinically significant IOL opacification after PPV were reviewed. The date of primary cataract surgery, technique and implanted IOL characteristics; the time, cause and technique of PPV; tamponade used; additional surgeries; the time of IOL calcification and explantation; and IOL explantation technique were investigated. Results: PPV had been performed as a combined procedure with cataract surgery in eight eyes and solely in six pseudophakic eyes. The IOL material was hydrophilic in six eyes, hydrophilic with a hydrophobic surface in seven eyes and undetermined in one eye. The endotamponades used during primary PPV were C2F6 in eight eyes, C3F8 in one eye, air in two eyes and silicone oil in three eyes. Two of three eyes underwent subsequent silicone oil removal and gas tamponade exchange. Gas in the anterior chamber was detected in six eyes after PPV or silicone oil removal. The mean interval between PPV and IOL opacification was 20.5 +/- 18.6 months. The mean BCVA in logMAR was 0.43 +/- 0.42 after PPV, which significantly decreased to 0.67 +/- 0.68 before IOL explantation for IOL opacification (p = 0.007) and increased to 0.48 +/- 0.59 after the IOL exchange (p = 0.015). Conclusions: PPV with endotamponades in pseudophakic eyes, particularly gas, seems to increase the risk for secondary IOL calcification, especially in hydrophilic IOLs. IOL exchange seems to solve this problem when clinically significant vision loss occurs.Article Evaluating Anterior Segment Stability and Corneal Endothelium After Prolene Gonioscopy Assisted Transluminal Trabeculotomy (gatt) in Open-Angle Glaucoma(Springer, 2024) Aribas, Yavuz Kemal; Aktas, Zeynep; Ertop, Mestan; Surgical SciencesIntroduction This study investigates the short-term effects of prolene gonioscopy-assisted transluminal trabeculotomy (GATT) on anterior segment parameters and corneal endothelium in patients with open-angle glaucoma. Methods This retrospective study included 30 eyes from 30 patients who underwent GATT surgery. Demographic data, ophthalmological examination findings, and intraocular pressure (IOP) measurements using a Goldman applanation tonometer were recorded. Scheimpflug images were acquired at the pre-operative stage, as well as on the 1st day, 1st week, and 1st month postoperatively. Corneal endothelial cell counts were obtained via specular microscopy. Results The mean age of patients was 60.3 +/- 15.5 years. Anterior chamber depth and central corneal thickness increased on the 1st postoperative day (p:0.002, p < 0.001, respectively). Changes in anterior chamber depth values at the postoperative 1st week and 1st month compared to baseline were not statistically significant. Central corneal thickness decreased significantly at the 1st postoperative month compared to baseline (p:0.007). Corneal endothelial cell counts at the 1st month were comparable to baseline values (p:0.936). Conclusion Our findings reveal that prolene gonioscopy-assisted transluminal trabeculotomy induces temporary changes in anterior segment parameters but preserves corneal endothelial cell count within the first month, suggesting a promising profile for GATT in glaucoma management.Article Revolutionizing Glaucoma Care: Harnessing Artificial Intelligence for Precise Diagnosis and Management(2025) Ucgul, Ahmet Yucel; Aktas, Zeynep; Surgical SciencesGlaucoma is a leading cause of irreversible blindness worldwide, necessitating early detection and effective management to prevent vision loss. Recent advancements in artificial intelligence (AI) have revolutionized glaucoma care by enhancing diagnostic accuracy, monitoring disease progression, and personalizing treatment strategies. AI models, including machine learning and deep learning algorithms, have demonstrated exceptional performance in analyzing fundus photography, optical coherence tomography, and visual field data, surpassing traditional diagnostic methods. Convolutional neural networks have shown high sensitivity and specificity in detecting glaucomatous changes, while vision transformers and hybrid AI models further refine risk assessment and prognosis. Additionally, AI- powered monitoring systems utilizing multi-modal data integration allow for more precise prediction of disease progression and the need for surgical intervention. The incorporation of AI into telemedicine and wearable intraocular pressure sensors extends glaucoma management to remote and underserved populations. Despite these advancements, challenges remain, including issues related to algorithm generalizability, data standardization, bias, and ethical concerns regarding AI-driven clinical decision-making. To maximize AI’s potential in glaucoma care, further interdisciplinary research, regulatory oversight, and multi-center validation studies are needed. By addressing these challenges, AI can be effectively integrated into clinical practice, leading to improved early detection, enhanced treatment strategies, and more personalized patient care. The future of AI in glaucoma management holds great promise, paving the way for a more data-driven and patient-centered approach to combating this sight-threatening disease.Article Citation - WoS: 19Citation - Scopus: 27Outcomes of Prolene Gonioscopy Assisted Transluminal Trabeculotomy in Primary Open Angle Glaucoma and Pseudoexfoliation Glaucoma: a Comparative Study(Lippincott Williams & Wilkins, 2022) Aktas, Zeynep; Zeydanli, Ece Ozdemir; Uysal, Betul Seher; Yigiter, Ahmet; Surgical SciencesPrecis: Gonioscopy-assisted transluminal trabeculotomy (GATT) provides greater intraocular pressure (TOP) reduction in pseudoexfoliative glaucoma (PXG) than in primary open angle glaucoma (POAG) in the first year of surgery; however, the difference between groups equalizes in the long term. Purpose: To compare outcomes of GATT in eyes with POAG and PXG. Methods: Single-center, retrospective, comparative case-series. A total of 202 eyes (91 eyes of POAG; 111 eyes of PXG) were included. GATT was performed as a standalone procedure or in combination with cataract extraction. Outcome measures were change in IOP and number of medications at all time points (1, 3, 6, 9, 12, 18, 24, and 36 mo after surgery), success rate (IOP reduction >= 20% from baseline or IOP between 6 and 21 mmHg, without further glaucoma surgery), and complication rate. Cumulative success probabilities were compared using Kaplan-Meier survival analyses. Results: The mean IOP decreased by 8.8 mmHg (34.4%) in the POAG group with a mean decrease of 2 glaucoma medications at final visit. In the PXG group, the mean IOP decreased by 12.8 mm Hg (44.6%) on 2.3 fewer medications. Mean IOP reduction was significantly higher in PXG than POAG at all time points up to 2-year visit (P < 0 .0 5 for all), after which the difference was not significant. Cumulative success probability during the first year was significantly higher in PXG (97.6%) than in POAG (86.8%) (P = 0.01); no significant difference was found at 2-year (P = 0.07) and 3-year visits (P = 0.24). Conclusion: GATT was safe and effectively reduced the IOP and medication burden in patients with POAG and PXG. In the first year after GATT, a significantly higher success rate was noted in PXG compared with POAG; however, in subsequent years, the success rate was similar at similar to 75%.Article Citation - Scopus: 2Gonioscopy-assisted transluminal trabeculotomy for congenital glaucoma secondary to Klippel-Trenaunay-Weber Syndrome: A case report(Elsevier Inc., 2022) Haidu,S.-D.; Aktas,Z.; Surgical SciencesPurpose: To describe the case of a 9-year-old boy with congenital glaucoma secondary to Klippel – Trenaunay - Weber Syndrome (KTW) with a history of trabeculotomy in both eyes (BE) and further trabeculectomy in the left eye (LE) presented with high intraocular pressure (IOP) and progression in the LE despite maximum tolerated medical therapy. Observations: GATT surgery was performed firstly in the LE, followed by the right eye (RE) two months apart since the IOP in the RE started to increase later on. First post-operative day the IOP was under 15 mmHg. In the last visit, 6 months after the first surgery, IOPs were 10 and 11 mmHg RE and LE, on one fixed combination; slit lamp examinations were normal with wide open angles and a good view of the Schlemm's Canal (SC) posterior wall. Conclusions and Importance: GATT surgery can be done after failed incisional surgery in children with glaucoma secondary to KTW syndrome. © 2022 The AuthorsArticle Citation - WoS: 8Citation - Scopus: 14Efficacy and Safety of Gonioscopy-Assisted Transluminal Trabeculotomy for Primary Congenital Glaucoma(Lippincott Williams & Wilkins, 2023) Aktas, Zeynep; Ozmen, Mehmet C.; Ozdemir Zeydanli, Ece; Oral, Merve; Eskalen, Oguzcan; Surgical SciencesPrecis:Gonioscopy-assisted transluminal trabeculotomy (GATT) provided effective intraocular pressure (IOP) control in primary congenital glaucoma (PCG). Also, approximately two third of patients did not need antiglaucoma medication at an average follow-up of 1 year after surgery. Purpose:The purpose of this study was to assess the safety and efficacy of GATT surgery in eyes with PCG. Materials and Methods:This study is a retrospective review of patients who underwent GATT surgery for PCG. Outcome measures were changes in IOP and number of medications at all time points (1, 3, 6, 9, 12, 18, 24, and 36 mo after surgery), and success rates. Success was defined as IOP<21 mm Hg with at least a 30% reduction from the baseline, complete if without medications, or qualified if with or without medications. Cumulative success probabilities were analyzed using the Kaplan-Meier survival analyses. Results:Twenty-two eyes of 14 patients diagnosed with PCG were enrolled in this study. The mean IOP reduction was 13.1 mm Hg (57.7%) with a mean decrease of 2 glaucoma medications at the final follow-up. All mean IOP readings during postoperative follow-up were significantly lower than baseline (P<0.05 for all). Cumulative probability of qualified success was 95.5% and the cumulative probability of complete success was 66.7%. Conclusion:GATT was safe and successfully lowered IOP in patients with PCG with the advantage of avoiding conjunctival and scleral incisions.Article Surgical Treatment of a Patient With Recurrent Bleb Leak and Glaucoma: Bleb Excision Combined With Gonioscopy-Assisted Transluminal Trabeculotomy(Galenos Publ House, 2022) Boluk, Ceyda Eristi; Aktas, Zeynep; Surgical SciencesHere we present a case of intermittent bleb leakage with increased intraocular pressure (IOP) during recovery periods that was treated with gonioscopy-assisted transluminal trabeculotomy (GATT) combined with avascular bleb excision. A 60-year-old woman exhibiting simultaneous leaking bleb and glaucoma underwent GATT and bleb revision. At her final visit, the bleb leakage had resolved and IOP was under control without any further antiglaucoma medication. GATT may be useful for glaucoma patients exhibiting intermittent bleb leakage after failed trabeculectomy.Correction Correction: Evaluating Anterior Segment Stability and Corneal Endothelium After Prolene Gonioscopy Assisted Transluminal Trabeculotomy (GATT) in Open-Angle Glaucoma(Springer, 2025) Aribas, Yavuz Kemal; Aktas, Zeynep; Ertop, Mestan; Surgical SciencesReview Citation - WoS: 7Citation - Scopus: 7Current Surgical Techniques for the Management of Pediatric Glaucoma: a Literature Review(Frontiers Media Sa, 2023) Aktas, Zeynep; Ikiz, Gokcen Deniz Gulpinar; Surgical Sciences; Surgical SciencesPediatric glaucoma surgery is challenging due to its diverse and complex pathophysiology, altered anterior segment anatomy, greater potential for failure, and complications compared to adult patients. Moreover, numerous challenges are associated with long-term postoperative management. Thus, when dealing with childhood glaucoma, it is important to consider the potential complications in addition to the benefits of each intervention. The purpose of this article is to review recently published literature to shed light on the most recent surgical techniques for the safe and effective treatment of childhood glaucoma. Current literature shows that goniotomy and trabeculotomy are the first choices for the management of primary congenital glaucoma. Although older children with phakic eyes seem to benefit from trabeculectomy with adjunctive mitomycin C, it carries a long-term risk of bleb-related endophthalmitis. Glaucoma drainage devices may be preferred for patients with secondary or refractory glaucoma. However, hypotony or tube-related complications are common and encountered more often in children than in adults. Cyclodestructive procedures are also an option for cases in which filtering surgery has failed, but they can also be used as a temporizing measure to reduce the rate of complications in high-risk patients. However, their outcomes can be unpredictable, in terms of efficiency and complications. Finally, minimally invasive glaucoma surgery (MIGS) as the sole alternative treatment or as an adjunctive surgical procedure is a relatively new path for pediatric patients.
