Filiz Korkmaz Özkan

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Citation - WoS: 357
Citation - Scopus: 374
A New Artificial Urine Protocol To Better Imitate Human Urine
(Nature Portfolio, 2019) Sarigul, Neslihan; Korkmaz, Filiz; Kurultak, Ilhan
Artificial urine has many advantages over human urine for research and educational purposes. By closely mimicking healthy individuals' urine, it may also be important in discovering novel biomarkers. However, up until now, there has not been any specific protocol to prove the similarity in terms of the chemical composition at the molecular level. In this study, a new artificial urine protocol is established to mimics the urine of healthy individuals. The multi-purpose artificial urine (MP-AU) presented here is compared with two other protocols most cited in literature. Furthermore, these three protocols are also compared with samples from 28 healthy young individuals. To do so, attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) is used, according to which MP-AU shows a significantly close similarity with human urine. In formulating MP-AU, the infrared spectra of nine compounds is provided, making possible the band assignment of some absorption bands to certain compounds. Given its properties, the MP-AU protocol introduced here is both economical and practical, making it useful when designing comparative-controlled experiments.
Compositional Dependence of Optical Modes Frequencies in T1ga_x< Layered Mixed Crystals (0 ≤ x ≤ 1)
(Polish Acad Sciences inst Physics, 2014) Isik, M.; Gasanly, N. M.; Korkmaz, F.
The infrared transmittance and Raman scattering spectra in TlGaxIn1-xS2 (0 <= x <= 1) layered mixed crystals grown by the Bridgman method were studied in the frequency ranges of 400-2000 and 250-400 cm(-1), respectively. The bands observed at room temperature in IR transmittance spectra of TlGaxIn1-xS2 were interpreted in terms of multiphonon absorption processes. The dependences of the frequencies of IR- and Raman-active modes on the composition of TlGaxIn1-xS2 mixed crystals were also established. The structural characterization of the mixed crystals was investigated by means of X-ray diffraction measurements and compositional dependence of lattice parameters was revealed.
Citation - WoS: 31
Citation - Scopus: 30
Interaction of a Novel Platinum Drug With Bovine Serum Albumin: Ftir and Uv-Vis Spectroscopy Analysis
(Royal Soc Chemistry, 2015) Korkmaz, Filiz; Erdogan, Deniz Altunoz; Ozalp-Yaman, Seniz
Platinum complexes have proven to be very effective in cancer treatment. However, severe side effects of these drugs have lead scientists to pursue new platinum complex derivatives. A novel blue platinum compound, called Platinum-Blue (Pt-Blue), is one of the promising candidate platinum compounds to be used for tumor treatment. In this study, the interaction of Pt-Blue with bovine serum albumin (BSA) has been investigated using UV-Vis and FTIR spectroscopy. One of the findings is that the drug-protein interaction type depends on the drug concentration. Though Pt-Blue is attached to the surface of BSA at high concentrations, it interacts with a hydrophobic region of the protein at low concentrations with a binding constant of 1.93 x 10(5) M-1. Spectroscopic results indicate the hydrophobic docking position to be around Trp 213 in domain II, which is surrounded by a number of Asp and Glu. During this interaction, helices such as helix-10, helix-18, helix-19 and helix-24 change orientation and/or partially unfold to make room for the compound. Binding constants at high and low concentrations of Pt-Blue are determined using UV-Vis spectroscopy, which are found to be comparable to cisplatin. FTIR spectroscopy also reveals that the interaction between Pt-Blue and BSA is noncovalent, which makes the candidate drug favorable because it is available for DNA binding while being carried by albumin.

Journal	Count
Scientific Reports	4
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy	2
Physica B: Condensed Matter	2
Archives of Biochemistry and Biophysics	2
Journal of Biomolecular Structure and Dynamics	1

Korkmaz Özkan, Filiz

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ZERO HUNGER

GOOD HEALTH AND WELL-BEING

QUALITY EDUCATION

GENDER EQUALITY

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AFFORDABLE AND CLEAN ENERGY

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PEACE, JUSTICE AND STRONG INSTITUTIONS

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24

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665

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9

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0

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27

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22

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600

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619

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22.22

Scopus Citations per Publication

22.93

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9

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