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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14411/22
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Article Citation - WoS: 29Citation - Scopus: 32Effects of Exercise Training on Anxiety in Diabetic Rats(Elsevier, 2019) Caliskan, Hasan; Akat, Firat; Tatar, Yakup; Zaloglu, Nezahet; Dursun, Ali Dogan; Bastug, Metin; Ficicilar, HakanDiabetes mellitus (DM) is a common health problem, which manifests itself with chronic hyperglycemia and impaired insulin action. The prevalence of anxiety disorders tends to be high in the diabetic population. Exercise has a well-known anxiolytic effect, also demonstrated on rodents, but the effect of exercise on the DM-induced anxiety is still unknown. Female, Wistar albino rats were randomly divided into four groups (n=8) (C; EX; DM; DM+EX). DM was induced by injection (i.p.; 50 mg/kg) of Streptozotocin (STZ). Rats exercised in moderate intensity on the treadmill (15m/min; 5 degrees; 30 min) for 5 weeks. Anxiety-like behavior (ALB) was evaluated by Open field test (OFT) and Elevated Plus Maze (EPM). According to OFT, central time and central entry have increased with in EX but not in DM+EX. There was no difference between C and DM. Central latency time didn't differ among groups. Unsupported rearing increased in both EX and DM+EX. There was no significant decrease in DM. Freezing time was significantly increased in the DM group. Exercise training reduced freezing time both in diabetic and non-diabetic animals. EPM results were similar. Time spent in open arm was increased significantly in exercise groups compared to their sedentary matches, and freezing time data were also parallel to OFT. Our study revealed that diabetes had shown an anxiogenic effect, which was not severe, and it only manifested itself on some behavioral parameters. Exercise training was reduced anxiety-like behavior both in diabetic and non-diabetic rats. However, because of the nature of exercise studies, it is hard to separate the anxiolytic effect of exercise from the alteration of locomotion.Article Citation - WoS: 22Citation - Scopus: 23Composite Nanofibers Incorporating Alpha Lipoic Acid and Atorvastatin Provide Neuroprotection After Peripheral Nerve Injury in Rats(Elsevier, 2020) Haidar, Mohammad Karim; Timur, Selin Seda; Kazanci, Atilla; Turkoglu, Omer Faruk; Gursoy, R. Neslihan; Nemutlu, Emirhan; Eroglu, HakanDespite the new treatment strategies within the last 30 years, peripheral nerve injury (PNI) is still a worldwide clinical problem. The incidence rate of PNIs is 1 in 1000 individuals per year. In this study, we designed a composite nanoplatform for dual therapy in peripheral nerve injury and investigated the in-vivo efficacy in rat sciatic nerve crush injury model. Alpha-lipoic acid (ALA) was loaded into poly lactic-co-glycolic acid (PLGA) electrospun nanofibers which would release the drug in a faster manner and atorvastatin (ATR) loaded chitosan (CH) nanoparticles were embedded into PLGA nanofibers to provide sustained release. Sciatic nerve crush was generated via Yasargil aneurism clip with a holding force of 50 g/cm(2). Nanofiber formulations were administered to the injured nerve immediately after trauma. Functional recovery of operated rat hind limb was evaluated using the sciatic functional index (SFI), extensor postural thrust (EPT), withdrawal reflex latency (WRL) and Basso, Beattie, and Bresnahan (BBB) test up to one month in the post-operative period at different time intervals. In addition to functional recovery assessments, ultrastructural and biochemical analyses were carried out on regenerated nerve fibers. L-929 mouse fibroblast cell line and B35 neuroblastoma cell line were used to investigate the cytotoxicity of nanofibers before in-vivo experiments. The neuroprotection potential of these novel nanocomposite fiber formulations has been demonstrated after local implantation of composite nanofiber sheets incorporating ALA and ATR, which contributed to the recovery of the motor and sensory function and nerve regeneration in a rat sciatic nerve crush injury model.Editorial Citation - WoS: 47Citation - Scopus: 47Emergency Changes in International Guidelines on Treatment for Head and Neck Cancer Patients During the Covid-19 Pandemic(Elsevier, 2020) Chaves, Aline Lauda Freitas; Castro, Ana Ferreira; Marta, Gustavo Nader; Junior, Gilberto Castro; Ferris, Robert L.; Giglio, Raul Eduardo; Kowalski, Luiz Paulo[No Abstract Available]Article Citation - WoS: 70Citation - Scopus: 77European Head and Neck Society Recommendations for Head and Neck Cancer Survivorship Care(Elsevier, 2022) Verdonck-de Leeuw, Irma; Hoşal, Ali Şefik; Dawson, Camilla; Licitra, Lisa; Eriksen, Jesper Grau; Hosal, Sefik; Singer, Susanne; Leemans, C. Rene; Hoşal, Ali Şefik; Surgical Sciences; Surgical SciencesSurvivors of head and neck cancer can experience long-term consequences of the cancer and subsequent treatments even after the cancer has resolved. Increasingly clinicians are aware of the social, psychological, financial, and emotional impacts of these cancers, in addition to the support required for the physical symptoms. This review provides recommendations on the long-term management and support required for survivors of head and neck cancer in the European healthcare setting.Article Citation - WoS: 7Citation - Scopus: 9Finite Element Analysis of Fgm Dental Crowns Using Phase-Field Approach(Elsevier, 2023) Sait, Ferit; Saeidi, Nazanin; Korkmaz, TuranFunctionally graded materials (FGMs) - categorized in advanced composite materials - are specially designed to reduce the stresses and failure due to material mismatches. Advances in manufacturing techniques have brought FGMs into use in a variety of applications. However, the numerical analysis is still challenging due to the difficulties in simulations of non-homogeneous material domains of complex parts. Presenting a numerical procedure that both facilitates the implementation of material non-homogeneity in geometrically complex mediums, and increases the accuracy of the calculations using a phase-field approach, this study investigates the usage of FGMs in dental prostheses. For this purpose, a porcelain fused to metal (PFM) mandibular first molar FGM crown is simulated and analyzed under the maximum masticatory bite force, and eventually the results are compared to a PFM crown prepared conventionally.Article Citation - WoS: 7Citation - Scopus: 9Histomorphometric and Biomechanical Evaluation of the Osseointegration Around Micro- and Nano-Level Boron-Nitride Coated Titanium Dental Implants(Elsevier, 2022) Ozmeric, Nurdan; Cakal, Gaye Ozgur; Gokmenoglu, Ceren; Ozmeric, Ahmet; Oduncuoglu, Bahar Fusun; Hacaloglu, Tugce; Kaftanoglu, BilginIntroduction: Titanium dental implants has been coated with different materials such as polymers and biomi-metic agents, bone morphogenetic protein, calcium phosphate to enhance surface properties of the titanium implants for osseointegration. The aim of this study was to evaluate the bone tissue healing around Boron Nitride-coated (BN-coated) titanium implants histomorphometrically and biomechanically and also observe the effect of different coating thicknesses on osseointegration. Materials and methods: BN was coated on dental titanium implants with two different coating thicknesses by using RF magnetron sputtering system. Totally fifty-four implants were inserted into the tibias' of 12 New Zealand rabbits bilaterally under general anesthesia. All animals were sacrificed after 4-weeks. Bone-implant contact (BIC) and new bone area/total area ratios (BATA) were calculated. Also, the removal torque (RT) test was performed. Results: The highest new bone area in the medullary cavity was around the nano-BN-coated surface with 15.70%. In micro-BN-coated surface and control group, this ratio was determined as 10.48% and 8.23%, respectively. The BIC ratios in upper-side of implants and cortical-associated BIC ratios in lower-side were found significantly higher in control and micro-BN-coated group than nano-BN-coated group (p > 0.05). Sim-ilar BIC values were observed between control and micro-BN-coated groups (p > 0.05). BATA values did not show statistically significant differences between all three groups (p > 0.05). The RT values measured in all groups were found comparable and no statistically significant differences were found (p > 0.05). Conclusion: No inflammatory reaction developed around any implant. Relatively more new bone formation around nano-BN-coated titanium implants indicates the promising osseoinductive effect of BN coating. BN-coated implants showed similar biomechanical and histomorphometrical outcomes to that of the conven-tional titanium implants through a 4-week evaluation period. (c) 2022 Elsevier Masson SAS. All rights reserved.Article Citation - WoS: 19Citation - Scopus: 21Fucoidan-Loaded Electrospun Polyvinyl-alcohol/Chitosan Nanofibers With Enhanced Antibacterial Activity for Skin Tissue Engineering(Elsevier, 2023) Puigmal, Arnau Cuesta; Ayran, Musa; Ulag, Songul; Altan, Eray; Guncu, Mehmet Mucahit; Aksu, Burak; Gunduz, OguzhanThe polymeric nanofiber may interact and control certain regeneration processes at the molecular level to repair damaged tissues. This research focuses on the development of characterization and antibacterial capabilities of polyvinyl alcohol (PVA)/chitosan (CS) nanofibres containing fucoidan (FUC) for tissue engineering as a skin tissue substitute. A control group consisting of 13% PVA/(0.1)% CS nanofiber was prepared. To confer anti-bacterial properties to the nanofiber, 10, 20, and 30 mg of FUC were incorporated into this control group. The scanning electron microscope (SEM) proved the homogeneous and beadless structures of the nanofibers. The antibacterial activity of the 13% PVA/(0.1)% CS/(10, 20, 30) FUC was tested against the S.aureus and E.coli and the results showed that with FUC addition, the antibacterial activities of the nanofibers increased. The biocompatibility test was performed with a fibroblast cell line for 1, 3, and 7 days of incubation and the results demonstrated that FUC addition enhanced the bioactivity of the 13% PVA/(0.1)% CS nanofibers. In addition, the biocompatibility results showed that 13% PVA/(0.1)% CS/10 FUC had the highest viability value for all incubation periods compared to the others. In addition, the tensile test results showed that; the maximum tensile strength value was observed for 13% PVA/(0.1)% CS/10 FUC nanofibers.Article Citation - WoS: 12Citation - Scopus: 12Exploring the hidden impact of the Covid-19 pandemic: The role of urbanization(Elsevier, 2022) Peren Arin, K.; Lacomba, Juan A.; Lagos, Francisco; Moro-Egido, Ana, I; Thum, Marcel; Arin, K. PerenWe examine the role of residential environments (urban/rural) in understanding the impact of the COVID-19 pandemic and the restrictions in nationwide movement on several socio-economic attitudes. We conducted large-scale surveys in four European countries (France, Germany, Spain, and the United Kingdom) before and after nationwide lockdowns were implemented. We investigate how the pandemic affected: (i) economic (economic insecurity), (ii) political (trust in domestic and international institutions), and (iii) social attitudes (loneliness), by controlling for the degree of urbanization, obtained from the geocodes of the survey respondents. Our results show that taking the degree of urbanization into account is not only relevant but is also essential. Compared to urban areas, in rural areas lockdowns led to a greater increase of economic insecurity and to a greater decrease in trust in domestic institutions. We also show that these results are particularly valid for women and households with children.Article Citation - WoS: 2Citation - Scopus: 2Investigations of Ph-Dependent Dynamic Properties of Ompg-16sl, an Outer Membrane Protein G Mutant by Atr-Ftir Spectroscopy(Elsevier, 2022) Yilmaz, Irem; Korkmaz, FilizIn this paper, the dynamic properties of outer membrane protein G mutant (OmpG-16SL) are investigated with ATR-FTIR spectroscopy. While OmpG-WT has 14 beta-strands in its structure, the mutant is designed to have 16 beta-strands with the intention of creating an enlarged pore. Loop L6 is elongated by introducing six residues, two of which are negatively charged. The solvent accessibility of the OmpG-16SL mutant is compared with WT and a previously reported mutant OmpG-16S by tracking the H-1/H-2 exchange kinetics in acidic and neutral buffer conditions. The exchange kinetics and dynamics in the fast and slow exchange phases are separately investigated using the 2DCOS technique, which enables the tracking of the structural changes at each phase of the exchange process. The results suggest that the mutant OmpG-16SL is equally exposed to buffer in both acidic and neutral pH conditions. Additionally, the time range in the fast phase is very short - one-tenth of that for WT - and most of the exchange is completed in this phase. This fast exchange within minutes is also indicative of the presence of highly flexible and/or unstructured regions. In all, the fast exchange rates independent of the buffer pH justify the assumption that there is an altered interaction among the charged residues, which leads to a steadily-open pore. The role of the side-chain interactions within the pore and between the loops involving the loop L6 is also discussed.Article Citation - WoS: 56Biomechanical Comparison of Implant Retained Fixed Partial Dentures With Fiber Reinforced Composite Versus Conventional Metal Frameworks: a 3d Fea Study(Elsevier, 2011) Erkmen, Erkan; Meric, Gokce; Kurt, Ahmet; Tunc, Yahya; Eser, AtilimFiber reinforced composite (FRC) materials have been successfully used in a variety of commercial applications. These materials have also been widely used in dentistry. The use of fiber composite technology in implant prostheses has been previously presented, since they may solve many problems associated with metal alloy frameworks such as corrosion, complexity of fabrication and high cost. The hypothesis of this study was that an FRC framework with lower flexural modulus provides more even stress distribution throughout the implant retained fixed partial dentures (FPDs) than a metal framework does. A 3-dimensional finite element analysis was conducted to evaluate the stress distribution in bone, implant-abutment complex and prosthetic structures. Hence, two distinctly different models of implant retained 3-unit fixed partial dentures, composed of Cr-Co and porcelain (M-FPD model) or FRC and particulate composite (FRC-FPD model) were utilized. In separate load cases, 300 N vertical, 150 N oblique and 60 N horizontal forces were simulated. When the FRC-FPD and M-FPD models were compared, it was found that all investigated stress values in the M-FPD model were higher than the values in the FRC-FPD model except for the stress values in the implant-abutment complex. It can be concluded that the implant supported FRC-FPD could eliminate the excessive stresses in the bone-implant interface and maintain normal physiological loading of the surrounding bone, therefore minimizing the risk of peri-implant bone loss due to stress-shielding. (C) 2010 Elsevier Ltd. All rights reserved.