TR-Dizin

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  • Article
    Influence of Synthesis Parameters on the Structural Formation of Mayenite via the Citrate Sol-Gel Method
    (Tubitak Scientific & Technological Research Council Turkey, 2025) Eryildirim, Busra; Oktar, Nuray; Dogu, Doruk
    Mayenite (Ca12Al14O33) has remarkable properties such as high oxygen mobility, ionic conductivity, and catalytic activity. It has many different applications, including oxide-conducting electrolytes, fluorescent lamps, moisture sensors, hydrogen-permeable membranes, oxygen pumps, hydrogen storage, and catalysis. However, pure and homogeneous mayenite synthesis parameters have not yet been fully explored. This study examines the effect of synthesis parameters including metal salt (MS) to citric acid (CA) molar ratios (1:1 and 1:2), pH (0.4-2), and calcination temperature (900-1200 degrees C) in citrate sol-gel method on the crystal structure of mayenite. Synthesized materials were examined by thermogravimetric (TG), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Raman spectroscopy, N2 adsorption-desorption, scanning electron microscopy (SEM), inductively coupled plasma-optical emission spectrometry (ICP-OES), Fourier-transform infrared spectroscopy (FTIR), and pyridine adsorbed diffuse reflectance Fourier-transformed infrared spectroscopy (DRIFTS) analyses. The results show that all 3 parameters contribute to the mayenite phase formation and different impurity phases can be observed depending on the synthesis parameters. With no pH adjustment and an MS to CA ratio of 1, other phases of calcium aluminate mostly form. Mayenite becomes the main phase by doubling the CA amount. Besides CA, pH is also an important factor in mayenite synthesis. When the pH was adjusted to 2 with the MS to CA ratio at 1:1, mayenite was formed as the main phase, but other phases of calcium aluminate were also observed in the structure. XRD results show that all parameters studied influence the crystal structure of the final material, including the calcination temperature. This study shows that pure mayenite can be synthesized with a calcination temperature of 1200 degrees C, at a pH of 2, and the MS to CA molar ratio of 1:2.
  • Article
    Citation - WoS: 3
    Citation - Scopus: 3
    Gonioscopy-Assisted Transluminal Trabeculotomy Versus Bent Ab Interno Needle Goniectomy in Patients With Open-Angle Glaucoma
    (Galenos Publ House, 2025) Ucgul, Ahmet Yucel; Ucgul, Rukiye Kilic; Aktas, Zeynep
    Amaç: Açık açılı glokomlu (AAG) hastalarda gonyoskopi yardımlı translüminal trabekülotomi (GATT) ile eğik iğne ab interno gonyektominin (BANG) etkinlik ve güvenliğini karşılaştırmak. Gereç ve Yöntem: Bu retrospektif karşılaştırmalı çalışma, GATT (34 göz) veya BANG (31 göz) uygulanan AAG tanılı 65 gözü içermektedir. Göz içi basınç (GİB), başlangıçta ve postoperatif takip vizitlerinde Goldmann applanasyon tonometresi ile ölçüldü. Cerrahi başarı, kısmi (GİB ≤21 mmHg ve ≥%20 azalma) ve tam (aynı kriterler ilaçsız) olarak kategorize edildi. Komplikasyonlar ve ek cerrahi gereksinimi not edildi. Bulgular: Ameliyat öncesi ortalama GİB, GATT grubunda 32,9±6,1 mmHg iken, BANG grubunda 31,8±5,4 mmHg idi. Son kontrolde, GATT grubunda ortalama GİB 15,8±4,5 mmHg’ye düşerken (%51,9 azalma), BANG grubunda 17,9±5,7 mmHg’ye (%43,7 azalma) düştü. Tam cerrahi başarı oranı GATT prosedürü için %88,2, BANG prosedürü için %61,3’tü. Erken cerrahi başarısızlıklar BANG grubunda daha sık görülürken, GATT grubunda erken başarısızlıklar daha nadir olsa da, geç dönemde cerrahi başarısızlıklar BANG grubuna göre daha sık izlendi. Her iki prosedürde de minimal komplikasyonlar görülmüş olup; en yaygın komplikasyon ise geçici hifemaydı. Sonuç: Bu çalışmada, GATT cerrahisinin, BANG cerrahisine kıyasla daha büyük ve daha sürdürülebilir GİB azalması sağladığı ve daha yüksek cerrahi başarı oranlarına sahip olduğu dikkate alındığında, AAG’nin yönetiminde GATT’ın daha güvenilir bir seçenek olduğu söylenebilir.
  • Article
    Citation - WoS: 3
    Citation - Scopus: 1
    Caval Valve Implantation Procedure in 7 Cases of Torrential Tricuspid Regurgitation and Step-By Description of the Procedure
    (Kare Publ, 2025) Sarıçam, Ersin; Barcin, Cem; Çelebi, Aksüyek Savaş; Asfour, Mohamed; Bozbas, Huseyin; İlkay, Erdoğan; Cam, Ersin; Celebi, Savas A.
    Tricuspid regurgitation (TR) is an increasingly prevalent and clinically significant health problem.1 Due to the growing understanding of the importance of TR, the tricuspid valve has transitioned from being a forgotten valve to one of significant concern. Tricuspid regurgitation is often functional, and as it progresses to moderate or severe stages, hospital admissions increase and prognosis worsens.1,2 There are no effective pharmacological treatments for TR, and the 5-year survival rate with medical management is reported to be less than 50%.3 Therefore, early diagnosis and timely intervention for TR is crucial. Both surgical and percutaneous treatment options are available for severe TR. The mortality rate for isolated TR surgery is generally high.4 In recent years, transcatheter treatments have become feasible for this patient group, and accumulating evidence shows that transcatheter treatment is superior to medical management.5,6 Transcatheter interventions for TR can be performed in 4 ways, 2 involving repair and 2 involving valve We aimed to present our experience with transcatheter caval valve implantation (CAVI) in 7 patients with torrential TR who were not suitable for surgical intervention or transcatheter edge-to-edge repair (T-TEER) due to severe coaptation defects, review the current literature, and provide a step-by-step description of the procedure.
  • Article
    Citation - WoS: 1
    Citation - Scopus: 1
    Fotorefraktif Keratektomi Sonrası Kullanılan Lotrafilcon A ve Senofilcon A Bandaj Kontakt Lenslerin Görme Rehabilitasyonu ve Oküler Konfora Etkisi
    (Galenos Publ House, 2024) Alacamli, Goksu; Yakar, Konuralp
    Amaç: Fotorefraktif keratektomi (FRK) sonrası kullanılan farklı iki silikon hidrojel bandaj kontakt lensin (BKL), görsel rehabilitasyon ve oküler konfora etkisini karşılaştırmak. Gereç ve Yöntem: Bu prospektif çalışmaya, miyopi ve/veya astigmatizma kırma kusurlarını düzeltmek için iki taraflı FRK ameliyatı geçiren 30 hastanın 60 gözü dahil edildi. Ameliyat sonrası sağ göze lotrafilcon A, sol göze ise senofilcon A materyalden üretilmiş BKL uygulandı. Ameliyat sonrası 5. günde, BKL’ler çıkartıldığında, subjektif oküler rahatsızlık semptomları 0 ila 10 arası bir ölçekte değerlendirildi; burada 0, hiç rahatsızlık olmadığını ve 10, maksimum rahatsızlığı gösterdi. Ameliyat sonrası her iki gözün sferik eşdeğerleri (SE) 15. gün ve 1. ayda karşılaştırıldı. Ameliyat sonrası SE’nin ≤ ±0,50 diyoptri olması emetropi olarak kabul edildi. Emetropi elde edilen hasta sayıları da postoperatif 15. gün ve 1. ayda karşılaştırıldı. Bulgular: Ameliyat sonrası 5 günlük sürede BKL’ler arasında oküler rahatsızlık skorları anlamlı farklılık göstermedi (p>0,05). Ancak ameliyat sonrası 15. gün ve 1. aydaki SE değerleri açısından iki lens arasında istatistiksel olarak anlamlı fark gözlendi (p<0,05). Senofilcon A materyal lens takılan gözlerde ameliyat sonrası görsel rehabilitasyonun daha iyi olduğu saptandı. Sonuç: Her iki BKL arasında FRK sonrası oküler rahatsızlık skorları bakımından anlamlı fark saptanmasa da, senofilcon A materyalden üretilmiş BKL ameliyat sonrası SE hedefinde daha iyi performans gösterdi.
  • Article
    Citation - WoS: 1
    Citation - Scopus: 2
    Cannabinoid Receptor Ligands Modulate Fibrosis and Inflammation in Idiopathic Pulmonary Fibrosis: a Preliminary Study
    (Tubitak Scientific & Technological Research Council Turkey, 2024) Kose, Sevil; Onen, Selin; Gizer, Merve; Boduroglu, Esin; Gonullu, Ugur; Korkusuz, Petek
    Background/aim: No specific pharmacological treatment regimen for idiopathic pulmonary fibrosis (IPF) exists. Therefore, new antiinflammatory therapeutic strategies are needed. Cannabinoids (CBs), known for their inflammation-modulating and antifibrotic effects, may be potential medication candidates for treating IPF. We aim to evaluate the inflammation-modulating and antifibrotic effects of CB receptor (CBR) agonists and antagonists in lipopolysaccharide-stimulated normal human lung fibroblast, epithelial cells, IPF fibroblast cells, and monocytes. Materials and methods: We detected CBRs in normal human lung fibroblasts (LL24) and IPF fibroblast cells (LL29), epithelial cells (A549) and monocytes (THP-1) by flow cytometry. We determined TGF-(31, IL-8, and TNF-alpha inflammatory cytokines in the LL24, LL29, A549, and THP-1 cell culture supernatants on days 1 and 5 by ELISA. We evaluated the cell viability in LL24, LL29, and A549 cells on days 1, 3, and 5 spectrophotometrically and detected collagen Type I (ColI) production in the LL24 and LL29 cell culture supernatants on days 1, 3, and 5 by ELISA. Results: LL24, LL29, A549, and THP-1 cells exhibited CB1 (CB1R) and CB2 (CB2R) receptors. CB1R and CB2R agonists WIN55,2122 and JWH015 inhibited fibroblastic and epithelial cell proliferation on day 5. TGF-(31 and TNF-alpha release increased, while IL-8 release decreased in LL24, LL29, A549, and THP-1 cells in response to the administration of WIN55,212-2 and JWH015 at a 10-2 mM concentration. CB1R and CB2R antagonists AM251 and AM630 did not block agonistic responses, suggesting a nonclassical CBRmediated pathway. CB2R agonist JWH015 decreased ColI expression in IPF lung fibroblasts LL29 on day 3. Conclusion: These results suggest that CB signaling regulates the progression of pulmonary inflammation and fibrosis via CBR activation. This may offer a potential pharmacological tool for developing antifibrosis therapies.
  • Article
    Citation - WoS: 1
    Citation - Scopus: 1
    Kardiyovasküler Aldatma-Salgını: Kardiyovasküler Tedavilerde Kandırma ve Yanlış Bilgilendirme Epidemisinin Yaygınlaşması
    (Baycınar Medical Publishing - Baycınar Tıbbi Yayıncılık, 2024) Demirkılıç, Ufuk; Tosun, Burcu
    Son zamanlarda, bazı kalp damar cerrahları sıklıkla yanıltıcı terimler kullanarak pazarlama amacıyla sosyal medyayı giderek daha fazla kullanmaktadır. “Kardiyovasküler aldatma- salgını” olarak adlandırdığımız bu eğilim, kardiyovasküler tedaviler için yanıltıcı reklamların salgın benzeri bir şekilde yayılmasını içeren bir durumu yansıtmaktadır. Bu tür yanlış bilgilere maruz kalmanın, profesyonel kaynaklardan gelen bilgiye doğal olarak güvenen hastaları tehlikeye atmakla kalmayıp, aynı zamanda tıbbi etik ve bilimsel doğruluğa olan kamu güvenini de zedelemektedir. Ayrıca, bu durum tedavi reddine ve olumsuz sağlık sonuçlarına da katkıda bulunmaktadır. Bu sorunları değerlendiren kapsamlı küresel düzenlemelerin yetersizliği, acilen daha etkili uygulama önlemlerine gereksinim olduğunu ortaya çıkarmaktadır.
  • Article
    Citation - WoS: 2
    Citation - Scopus: 2
    Regional Variations in Psoriatic Arthritis: Insights From a Nationwide Multicenter Analysis in Türkiye
    (Turkish League Against Rheumatism, 2024) Kılıç, Erkan; Kılıç, Gamze; Tekeoğlu, İbrahim; Sargın, Betül; Kasman, Sevtap Acer; Alkan, Hakan; Nas, Kemal; Yurdakul, Ozan Volkan; Duruöz, Mehmet Tuncay; Ayhan, Fikriye Figen; Bodur, Hatice; Kandur, Yaşar; Sunar, İsmihan
    Objectives: The study aimed to investigate and compare clinical features, disease activity, and the overall disease burden among psoriatic arthritis (PsA) patients across seven distinct geographic regions in Türkiye. Patients and methods: A multicenter cross-sectional study involving 1,134 PsA patients from 25 referral centers across seven regions was conducted. Demographic and clinical characteristics, comorbidities, joint involvement, extra-articular manifestations, and disease activity measures were evaluated across regions. Results: A total of 1134 PsA patients from seven different geographic regions in Türkiye participated in this study. The highest number of participants was from the Marmara region (n=409), with subsequent representation from Central Anatolia (n=370), Aegean (n=139), Mediterranean (n=60), Black Sea (n=60), Eastern Anatolia (n=60), and Southeastern Anatolia (n=36) regions. There were significant variations in demographic profile, including age, body mass index, age of disease onset, educational status, comorbidities, and family history of both psoriasis and PsA. Clinical features, such as enthesitis, dactylitis, uveitis, and joint involvement, demonstrated significant variation across regions. Additionally, disease activity measures, including pain, patient and physician global assessments, acute phase reactants, disease activity indices, quality of life, and functional status, displayed considerable regional differences. Conclusion: This nationwide study revealed substantial regional diversity in demographic data, clinical characteristics, disease activity, and quality of life among PsA patients in Türkiye. These findings stress the need to customize treatment approaches to address regional needs and to conduct further research to uncover reasons for disparities. It is crucial to enhance region-specific approaches to improve patient care and outcomes for PsA.
  • Article
    Citation - WoS: 1
    Citation - Scopus: 1
    Short-Term Effectiveness of Epidermis Dermis Fascia Kinesiotaping Technique in Myofascial Pain Syndrome on Upper Trapezius: a Multi-Center, Double-Blind, Randomized Clinical Study
    (Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2024) Ayhan, Fikriye Figen; Külcü, Duygu Geler; Keleş, Elif Çiğdem; Dinç, Arzu; Mesci, Nilgün; Çakmak, Bahar; Yılmaz, Zeynep Alpoğuz; Erhan, Belgin; Yavas, Arzu Ding; Kölcö, Duygu Geler; Tur, Birkan Sonel
    Objectives: This study aims to investigate the efficacy of epidermis dermis fascia (EDF) kinesiotaping (KT) technique on pain intensity, number of active trigger points (TrPs), cervical range of motion (ROM) angles, and disability levels in patients with myofascial pain syndrome (MPS) on upper trapezius (UT) muscle. Patients and methods: Between January 2019 and January 2020, a total of 180 patients (21 males, 159 females; mean age: 35.9±9.0 years; range, 18 to 56 years) with MPS were included. The patients were randomized into either KT with EDF technique (Group 1) or sham KT (Group 2). Outcome measures were Visual Analog Scale (VAS) pain score, number of active TrPs, cervical ROM angles, and Neck Pain Disability Scale (NPDS). Results: Both groups improved in terms of all outcome parameters except for cervical flexion and extension angles in Group 2. The VAS pain scores significantly decreased in Group 1 (p<0.05), compared to Group 2. The number of active TrPs (p=0.001) and NPDS scores (p=0.016) of Group 1 significantly improved than Group 2. Cervical flexion (p=0.001), extension (p=0.001), and left and right lateral flexion angles (p<0.0001) significantly improved in Group 1. Cervical left (p=0.001) and right (p<0.0001) lateral flexion angles significantly improved in Group 2. There was no significant difference between the groups regarding cervical ROM angles. Conclusion: Our study results suggest that KT with the EDF technique is an effective method in reducing pain and number of active TrPs, improving disability and cervical ROM angles.
  • Article
    Citation - WoS: 2
    Citation - Scopus: 2
    The Relationship Between Lung Function, Exercise Capacity, Oxidant and Antioxidant Response in Primary Ciliary Dyskinesia and Cystic Fibrosis
    (Turkish J Pediatrics, 2024) Kartal, Yasemin; Ozel, Cemile Bozdemir; Cakmak, Aslihan; Ulu, Hazal Sonbahar; Ince, Deniz Inal; Tural, Dilber Ademhan; Sabuncuoglu, Suna; Özçelik, Uğur; Inal-ınce, Deniz; Budak, Murat; Arıkan, Hülya
    Background. There is a need to identify the complex interplay between various physiological mechanisms in primary ciliary dyskinesia (PCD) and cystic fibrosis (CF). The study investigated the interaction between respiratory function, exercise capacity, muscle strength, and inflammatory and oxidant/antioxidant responses in patients with PCD and CF. Methods. The study included 30 PCD patients, 30 CF patients, and 29 age and sex-matched healthy subjects. Exercise capacity was assessed using the modified shuttle walk test (MSWT). Handgrip strength (HGS) was used to evaluate general muscle strength. Oxidative stress-inflammatory parameters were also assessed. Pulmonary function test was performed by spirometry. Regarding the forced expiratory volume in 1 second (FEV1) 1 ) z-score, patients with PCD and CF were subdivided into normal, mild, and severe/moderate groups. Results. Forced vital capacity (FVC) z-scores were lower in PCD and CF patients than controls. FEV1, 1 , FEV1/ 1 / FVC, peak expiratory flow (PEF), and forced mid expiratory flow (FEF 25-75% ) z-scores were lower in PCD than in the other groups. HGS was lower in both mild PCD and normal CF patients relative to the controls. MSWT distance was lower in severe/moderate PCD patients than controls. Catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), and malondialdehyde (MDA) levels did not differ significantly among the study groups, but superoxide dismutase (SOD) level in severe/moderate PCD, and glutathione (GSH) level in normal CF were higher than in controls. Interleukin-6 (IL-6) level was higher in patients with normal PCD and CF compared to the controls. IL-1 beta level was higher in PCD compared to controls. Additionally, correlations among these parameters were also determined in some patient groups. Conclusion. Homeostasis related to respiratory function, aerobic performance, muscle strength, inflammatory response, and oxidant/antioxidant balance were affected in PCD and CF. Evaluating these mechanisms together may contribute to elucidating the pathophysiology of these rare diseases.
  • Article
    Citation - Scopus: 5
    Real-World Data From Turkey: Is Sofosbuvir/Ledipasvir With or Without Ribavirin Treatment for Chronic Hepatitis C Really Effective?
    (AVES, 2021) Demirtürk,N.; Aygen,B.; Çelik,İ.; Mıstık,R.; Akhan,S.; Barut,Ş.; Doğan,N.; Karakeçili, Faruk; Asan, Ali; Özel, Selcan Arslan; Ersöz, Gülden; Yıldız, Orhan; Şimşek, Sümeyra; Tarakçı, Hüseyin
    Background: In this study, we aimed to investigate the efficacy and safety of sofosbuvir-based therapies in the treatment of chronic hepatitis C in real-world clinical practice. Methods: Data from patients with chronic hepatitis C treated with SOF/LDV ± RBV or SOF/RBV in 31 centers across Turkey between April 1, 2017, and August 31, 2018, were recorded in a nationwide database among infectious disease specialists. Demographics, clinical, and virological outcomes were analyzed. Results: A total of 552 patients were included in the study. The mean age of the patients was 51.28 ± 14.2, and 293 (55.8%) were female. The majority had HCV genotype 1b infection (65%), 75.04% of the patients underwent treatment, and non-cirrhosis was present at baseline in 381 patients (72.6%). SOF/LDV ± RBV treatment was given to 477 patients and 48 patients received SOF/RBV according to HCV genotype. The total SVR12 rate was 99% in all patients. Five patients experienced disease relapse during the study and all of them were genotype 2. In patients infected with HCV GT2, SVR12 was 77.3%. SVR was 100% in all patients infected with other HCV genotypes. All treatments were well tolerated by patients without causing severe adverse events. Side effects and side effects-associated treatment discontinuation rates were 28.2% and 0.4%, respectively. Weakness (13.7%) was the common side effect. Conclusion: The present real-world data of 525 patients with HCV genotypes 1, 1a, 1b, 3, 4, and 5 who underwent SOF/LDV ± RBV treatment in Turkey demonstrated a high efficacy and safety profile. HCV GT2 patients should be treated with more efficacious treatment. © Copyright 2021 by The Turkish Society of Gastroenterology • Available online at turkjgastroenterol.org