Browsing by Author "Korkusuz,P."

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Citation - Scopus: 31
Architecture of Bone Tissue and Its Adaptation To Pathological Conditions
(Elsevier, 2020) Bilgiç,E.; Boyacıoğlu,Ö.; Gizer,M.; Korkusuz,P.; Korkusuz,F.
Bone tissue is a mineralized and viscous-elastic connective tissue, which exerts crucial functions in our body such as support and protection of other tissues and mineral storage. Bone can adapt itself through a remodeling process, which is controlled by its cells, various local and systemic factors. It is a very complicated process composed of both cellular reactions and its effects on the internal structure of the bone. An imbalance between bone resorption and formation due to disease may alter its structure and mechanics. Mechanical properties of bone tissue are affected by different loading grades. Collagen material found in the extracellular matrix gives bone its elasticity. Bone is, nevertheless, a fragile structure depending on the loading and mineral content that also strengthens the bone. In this chapter, the structure of the bone in micro and macro scale, its mechanical properties in physiological circumstances and adaptation to pathological conditions will be discussed. © 2020 Elsevier Inc. All rights reserved.
Citation - Scopus: 6
Cannabinoids as Prospective Anti-Cancer Drugs: Mechanism of Action in Healthy and Cancer Cells
(Springer, 2023) Boyacıoğlu,Ö.; Korkusuz,P.
Endogenous and exogenous cannabinoids modulate many physiological and pathological processes by binding classical cannabinoid receptors 1 (CB1) or 2 (CB2) or non-cannabinoid receptors. Cannabinoids are known to exert antiproliferative, apoptotic, anti-migratory and anti-invasive effect on cancer cells by inducing or inhibiting various signaling cascades. In this chapter, we specifically emphasize the latest research works about the alterations in endocannabinoid system (ECS) components in malignancies and cancer cell proliferation, migration, invasion, angiogenesis, autophagy, and death by cannabinoid administration, emphasizing their mechanism of action, and give a future perspective for clinical use. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.
Citation - Scopus: 15
From Nutrition To Medicine: Assessing Hemorrhoid Healing Activity of Solanum Melongena L. Via in Vivo Experimental Models and Its Major Chemicals
(Elsevier Ireland Ltd, 2020) Dönmez,C.; Yalçın,F.N.; Boyacıoğlu,Ö.; Korkusuz,P.; Akkol,E.K.; Nemutlu,E.; Çalışkan,U.K.
Ethnopharmacological relevance: Solanum melongena L. (eggplant) is used for treatment of rheumatism, beriberi, itching, toothache, bleeding, asthma, bronchitis, cholera, neuralgia and hemorrhoids in traditional medicine (Turkish, Chinese, and Indian). Hemorrhoids from these diseases, are common illness in all over the world, which are treated with various approaches including ethnobotanicals. Aim of the study: This study aimed to evaluate the anti-hemorrhoidal activity of eggplant, an edible plant, which is commonly utilized around the world. Materials & methods: In vivo anti-hemorrhoidal activity of the methanolic extract prepared from eggplant was evaluated by experimental hemorrhoid model, subsequently histological and biochemical analysis. Hemorrhoid, which was induced by applying croton oil to the anal area of the rats. Furthermore, the extract was screened for anti-inflammatory activity which is based on the inhibition of acetic acid-induced increase in capillary permeability. The healing potential was comparatively assessed with a reference Pilex® tablet and cream. Phytochemical analysis performed by HPLC. The amount of the major phenolic compound (chlorogenic acid) in extract was found by using HPLC method. Results: Histological and biochemical analysis demonstrated that eggplant extract is highly effective against hemorrhoid in comparison to the controls and the commercial preparation. In addition, the methanolic extract demonstrated significant inhibitory effect on acetic acid-induced increase in capillary permeability. The phytochemical studies identified major compound as chlorogenic acid (2.86%) by liquid chromatography. Conclusion: The eggplant calyxes, not edible, are easy to reach, by products/vast from the food sources. This is the first scientific evidence revealing that the eggplant extract has significant anti-hemorrhoidal and anti-inflammatory activity. © 2020 Elsevier B.V.
Morphogenesis and Biomechanics of the Human Embryo and Fetus
(Elsevier, 2020) Köse,S.; Baykal,B.; Korkusuz,F.; Korkusuz,P.
Human embryo begins moving at tissue, cell and sub-cellular levels long before the mother emotionally feels the movement of the fetus. The human embryo and fetus not only develop in a mechanical environment but they exaggerate mechanical forces on themselves and their surroundings. Mechanical forces in example influence embryonic musculoskeletal development. In this chapter, the development and morphogenesis of human musculoskeletal system will be overviewed with their molecular aspects and the biomechanics of embryo and fetus will be discussed. © 2020 Elsevier Inc. All rights reserved.
Citation - Scopus: 2
Trace Element Containing Nano-HAp for Preventing Musculoskeletal Infections
(Springer Science and Business Media B.V., 2021) Gizer,M.; Boyacıoğlu,Ö.; Korkusuz,P.; Korkusuz,F.
Musculoskeletal infections are difficult to diagnose and rapidly reach the chronic phase that is difficult to treat. Osteomyelitis and septic arthritis are inflammatory musculoskeletal diseases and their recovery should contain bone or joint regeneration approaches. Nanometer-sized hydroxyapatite is the main inorganic component of the bone tissue that resembles its extracellular matrix. Nanometer-sized hydroxyapatite composite is also an efficient carrier for various regenerative molecules and medicine. Trace elements on the other hand enhance bone formation, mineralization and have antibacterial properties. Bioactivity, biocompatibility, and antibacterial properties of nanometer-sized hydroxyapatite can be gained and improved with trace elements such as zinc, boron, magnesium, strontium, and molybdenum. This chapter summarizes studies on the effects of zinc, boron, magnesium, strontium, and/or molybdenum-doped nanometer-sized hydroxyapatite that can be used to treat musculoskeletal infections. © 2021, The Author(s), under exclusive license to Springer Nature Switzerland AG.