Browsing by Author "Gizer,M."
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Book Part Citation Count: 23Architecture of bone tissue and its adaptation to pathological conditions(Elsevier, 2020) Boyacıoğlu, Özge; Boyacıoğlu,Ö.; Gizer,M.; Korkusuz,P.; Korkusuz,F.; Basic SciencesBone tissue is a mineralized and viscous-elastic connective tissue, which exerts crucial functions in our body such as support and protection of other tissues and mineral storage. Bone can adapt itself through a remodeling process, which is controlled by its cells, various local and systemic factors. It is a very complicated process composed of both cellular reactions and its effects on the internal structure of the bone. An imbalance between bone resorption and formation due to disease may alter its structure and mechanics. Mechanical properties of bone tissue are affected by different loading grades. Collagen material found in the extracellular matrix gives bone its elasticity. Bone is, nevertheless, a fragile structure depending on the loading and mineral content that also strengthens the bone. In this chapter, the structure of the bone in micro and macro scale, its mechanical properties in physiological circumstances and adaptation to pathological conditions will be discussed. © 2020 Elsevier Inc. All rights reserved.Book Part Citation Count: 2Trace Element Containing Nano-HAp for Preventing Musculoskeletal Infections(Springer Science and Business Media B.V., 2021) Boyacıoğlu, Özge; Boyacıoğlu,Ö.; Korkusuz,P.; Korkusuz,F.; Basic SciencesMusculoskeletal infections are difficult to diagnose and rapidly reach the chronic phase that is difficult to treat. Osteomyelitis and septic arthritis are inflammatory musculoskeletal diseases and their recovery should contain bone or joint regeneration approaches. Nanometer-sized hydroxyapatite is the main inorganic component of the bone tissue that resembles its extracellular matrix. Nanometer-sized hydroxyapatite composite is also an efficient carrier for various regenerative molecules and medicine. Trace elements on the other hand enhance bone formation, mineralization and have antibacterial properties. Bioactivity, biocompatibility, and antibacterial properties of nanometer-sized hydroxyapatite can be gained and improved with trace elements such as zinc, boron, magnesium, strontium, and molybdenum. This chapter summarizes studies on the effects of zinc, boron, magnesium, strontium, and/or molybdenum-doped nanometer-sized hydroxyapatite that can be used to treat musculoskeletal infections. © 2021, The Author(s), under exclusive license to Springer Nature Switzerland AG.