Risk Factors for Rectal Colonization with Carbapenemase Producing <i>Enterobacteriaceae</i>

dc.authorid Kaya Kılıç, Esra/0000-0002-3270-4841
dc.authorid Yucel, Mihriban/0000-0003-4258-8538
dc.authorid Ozcan, Ayse/0000-0002-5224-554X
dc.authorid ERDINC, FATMA SEBNEM/0000-0003-3918-564X
dc.authorid Erdinç, Fatma Şebnem/0000-0003-3918-564X
dc.authorid Ertem, Gunay/0000-0001-8760-0030
dc.authorwosid Kaya Kılıç, Esra/ABI-6469-2020
dc.authorwosid Yucel, Mihriban/IAP-8842-2023
dc.authorwosid Tulek, Necla/M-3283-2017
dc.authorwosid Ozcan, Ayse/GVS-9243-2022
dc.authorwosid ERDINC, FATMA SEBNEM/O-9971-2018
dc.authorwosid Erdinç, Fatma Şebnem/AAQ-6746-2021
dc.authorwosid Ertem, Gunay/GRJ-7397-2022
dc.contributor.author Hekimoglu, Sirin
dc.contributor.author Ertem, Gunay
dc.contributor.author Yucel, Mihriban
dc.contributor.author Basar, Hulya
dc.contributor.author Kaya Kilic, Esra
dc.contributor.author Ozcan, Ayse
dc.contributor.author Tulek, Necla
dc.contributor.other Basic Sciences
dc.date.accessioned 2024-07-05T15:18:43Z
dc.date.available 2024-07-05T15:18:43Z
dc.date.issued 2021
dc.department Atılım University en_US
dc.department-temp [Hekimoglu, Sirin] Ordu Univ Egitim & Arastirma Hastanesi, Infeksiyon Hastaliklari & Klin Mikrobiyol Klin, Ordu, Turkey; [Ertem, Gunay; Kaya Kilic, Esra; Erdinc, Fatma Sebnem] Saglik Bilimleri Univ, Ankara Saglik Uygulama & Arastirma Merkezi, Infeksiyon Hastaliklari & Klin Mikrobiyol Klin, Ankara, Turkey; [Yucel, Mihriban] Saglik Bilimleri Univ, Ankara Saglik Uygulama & Arastirma Merkezi, Tibbi Mikrobiyol Klin, Ankara, Turkey; [Basar, Hulya; Ozcan, Ayse] Saglik Bilimleri Univ, Ankara Saglik Uygulama & Arastirma Merkezi, Anestezi & Reanimasyon Klin, Ankara, Turkey; [Tulek, Necla] Atilim Univ, Tip Fak, Infeksiyon Hastaliklari & Klin Mikrobiyol Anabili, Ankara, Turkey en_US
dc.description Kaya Kılıç, Esra/0000-0002-3270-4841; Yucel, Mihriban/0000-0003-4258-8538; Ozcan, Ayse/0000-0002-5224-554X; ERDINC, FATMA SEBNEM/0000-0003-3918-564X; Erdinç, Fatma Şebnem/0000-0003-3918-564X; Ertem, Gunay/0000-0001-8760-0030 en_US
dc.description.abstract Introduction: Carbapenem-resistant Enterobacteriaceae (CRE) is the most common pathogens acquired in intensive care units (ICU). Materials and Methods: This study was designed as prospective observational study at the Ankara Healthcare Application and Research Center of the University of Health Sciences. The study was conducted between September 2017 and May 2018 in the tertiary Anesthesiology and Reanimation ICU. Rectal swab samples were taken from each hospitalized patient during hospitalization and weekly thereafter. Sixty-five patients with CRE colonization were considered as the study group and 65 patients without CRE colonization were considered as the control group. Results: The 51% of the cases are male and 49% are females. The mean age of all cases was 69.1 +/- 17.6 and the median age was 73. The majority of bacteria grown in rectal swabs are constituted by Klebsiella pneumoniae (43-58.1%) and Escherichia colt (16-21.6%). Duration of hospitalization in the ICU was 19.6 +/- 15.8 in the control group and 48.5 +/- 38.2 in the study group. Duration of hospitalization in CRE-infected patients were longer than non-infected patients (p<0.001). The use of a central venous catheter and tracheostomy showed statistically significant difference between the groups (p< 0.05). Nineteen cases (29.2%) had CRE positivity at their admission to the ICU. Eighteen of these patients came from another clinical service or hospital (p< 0.005). In the control group, carbapenem was used in a mean of 11.9 +/- 9.9 days and in the study group a mean of 16.3 +/- 8.5 days (p= 0.002). In multivariate analysis of risk factors, duration of hospitalization in the ICU increases the risk of CRE positivity in rectal culture 1.04 (95%GA, 1,005-1,072, p= 0.024) times more. Conclusion: In our study, it can be said that it is important to question the indications of invasive procedures to be applied to the patients. We recommend that patients should be admitted to service follow-up when the ICU follow-up and treatment indications are terminated. Carbapenem treatment times should be shortened. As a result, it would be wise to take rectal surveillance cultures in ICUs to detect and control carbapenem-resistant strains. en_US
dc.identifier.citationcount 0
dc.identifier.doi 10.5578/flora.20219619
dc.identifier.endpage 735 en_US
dc.identifier.issn 1300-932X
dc.identifier.issue 4 en_US
dc.identifier.startpage 727 en_US
dc.identifier.trdizinid 505161
dc.identifier.uri https://doi.org/10.5578/flora.20219619
dc.identifier.uri https://hdl.handle.net/20.500.14411/1897
dc.identifier.volume 26 en_US
dc.identifier.wos WOS:000740371500020
dc.institutionauthor Tülek, Necla
dc.language.iso tr en_US
dc.publisher Bilimsel Tip Yayinevi en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Enterobacteriaceae en_US
dc.subject Carbapenemase en_US
dc.subject Colonization en_US
dc.title Risk Factors for Rectal Colonization with Carbapenemase Producing <i>Enterobacteriaceae</i> en_US
dc.type Article en_US
dc.wos.citedbyCount 0
dspace.entity.type Publication
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