Serum Asporin Levels in Maintenance Hemodialysis Patients Without Osteoarthritis

dc.authorscopusid 57196954194
dc.authorscopusid 56640960500
dc.contributor.author Dursun, Ali Doğan
dc.contributor.author Dursun, Ali Doğan
dc.contributor.author Demir, Canan
dc.contributor.author Demir, Canan
dc.contributor.author Dursun, Ali Doğan
dc.contributor.author Demir, Canan
dc.contributor.other Basic Sciences
dc.contributor.other Basic Sciences
dc.date.accessioned 2024-07-05T15:50:17Z
dc.date.available 2024-07-05T15:50:17Z
dc.date.issued 2023
dc.department Atılım University en_US
dc.department-temp ATILIM ÜNİVERSİTESİ,ATILIM ÜNİVERSİTESİ en_US
dc.description.abstract Aims: Several human and experimental studies have shown that small leucine-rich proteoglycans might play a significant role in inflammation and fibrosis in various renal diseases. However, as far as we know, no study has reported asporin levels in patients with advanced renal disease. The primary aim of this study was to determine serum asporin levels in hemodialysis (HD) patients without symptomatic osteoarthritis. Methods: This single-center, cross-sectional study prospectively enrolled maintenance HD patients and healthy control subjects. Subjects with clinically clear osteoarthritis were excluded. Serum asporin level was measured via Human ASPN (Asporin) ELISA Kit (Elabscience Biotechnology Inc. Houston, Texas, USA) in fasting blood samples. Results: The study included 25 (mean age: 43.3±13.5 years, 60% were females) patients and 29 control subjects (mean age: 38.0±8.8 years, 37.9% were females). Patients and controls were similar in age and sex. Serum asporin levels were significantly higher in HD patients compared with the controls 2.4 (0.9-4.8) ng/mL vs. 0.3 (0.2-0.6) ng/mL, respectively, p<0.001). Asporin levels were not correlated with age (r=0.344, p=0.092) and the duration of HD (r=0.385, p=0.077). Among HD patients, asporin level was not significantly correlated with C-reactive protein, parathyroid hormone, calcium, or phosphorus levels. Conclusions: This study showed that serum asporin levels were significantly elevated in patients undergoing HD. Further studies must elucidate the possible origins of increased asporin in these patients. en_US
dc.identifier.citationcount 0
dc.identifier.doi 10.4274/gulhane.galenos.2022.97658
dc.identifier.endpage 43 en_US
dc.identifier.issn 1302-0471
dc.identifier.issn 2146-8052
dc.identifier.issue 1 en_US
dc.identifier.scopus 2-s2.0-85150224552
dc.identifier.scopusquality Q3
dc.identifier.startpage 39 en_US
dc.identifier.trdizinid 1175859
dc.identifier.uri https://doi.org/10.4274/gulhane.galenos.2022.97658
dc.identifier.uri https://search.trdizin.gov.tr/tr/yayin/detay/1175859/serum-asporin-levels-in-maintenance-hemodialysis-patients-without-osteoarthritis
dc.identifier.volume 65 en_US
dc.institutionauthor Dursun, Ali Doğan
dc.institutionauthor Demir, Canan
dc.language.iso en en_US
dc.publisher Galenos Publishing House en_US
dc.relation.ispartof Gülhane Tıp Dergisi en_US
dc.relation.publicationcategory Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 0
dc.title Serum Asporin Levels in Maintenance Hemodialysis Patients Without Osteoarthritis en_US
dc.type Article en_US
dspace.entity.type Publication
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