Physical and Biological Characteristics of Electrospun Poly (vinyl Alcohol) and Reduced Graphene Oxide Nanofibrous Structure

Loading...
Thumbnail Image

Date

2024

Journal Title

Journal ISSN

Volume Title

Publisher

Taylor & Francis Ltd

Open Access Color

OpenAIRE Downloads

OpenAIRE Views

Research Projects

Organizational Units

Journal Issue

Events

Abstract

The fabrication of graphene-based nanocomposites has been a topic of increasing interest due to graphene's exceptional physical properties and the ability to enhance the properties of various polymeric materials. Evaluating the biocompatibility of these nanocomposites is crucial to ensure their safe and effective use in biomedical applications. This study characterized and assessed the biocompatibility of previously fabricated electrospun polyvinyl alcohol (PVA)/reduced graphene oxide rGO fibrous structures by conducting a comprehensive assessment of their physical and biological characteristics. Contact angle measurements revealed that adding rGO to electrospun PVA fibers enhanced the surface wettability, improving the fibrous structure's PBS absorption capacity and degradation behavior. Including the rGO content resulted in a higher water vapor transmission rate, reaching similar to 48 g/m2<middle dot>day for PVA + 0.5 wt.% rGO and similar to 45 g/m2<middle dot>day for PVA + 1.0 wt.% rGO, compared to similar to 40 g/m2<middle dot>day for electrospun PVA fibers. Cell culture studies, including MTT assay, alkaline phosphatase (ALP) activity analysis, alizarin red staining, fluorescence microscopy, and SEM analyses, demonstrated that electrospun PVA + 1.0 wt.% rGO nanocomposites exhibited superior cell viability, proliferation, and growth compared to other samples, due to the improved physical properties of the PVA + 1.0 wt.% rGO fibrous structure.

Description

Turkoglu Sasmazel, Hilal/0000-0002-0254-4541

Keywords

Electrospinning, PVA, rGO, MG-63 cell line, nanocomposite

Turkish CoHE Thesis Center URL

Fields of Science

Citation

WoS Q

Q3

Scopus Q

Q3

Source

Volume

Issue

Start Page

End Page

Collections