Study on the Cytocompatibility, Mechanical and Antimicrobial Properties of 3d Printed Composite Scaffolds Based on Pva/ Gold Nanoparticles (aunp)/ Ampicillin (amp) for Bone Tissue Engineering

dc.authorid Gunduz, Oguzhan/0000-0002-4926-6489
dc.authorid Kalaskar, Deepak/0000-0002-0576-1816
dc.authorid Gunduz, Oguzhan/0000-0002-9427-7574
dc.authorid Turkoglu Sasmazel, Hilal/0000-0002-0254-4541
dc.authorid TUKAY, Ari Kutlug/0000-0001-9378-2635
dc.authorscopusid 57202390255
dc.authorscopusid 55779339700
dc.authorscopusid 37098428300
dc.authorscopusid 57224535178
dc.authorscopusid 16680382000
dc.authorscopusid 24070966200
dc.authorscopusid 24070966200
dc.authorwosid Gunduz, Oguzhan/AAA-3212-2019
dc.authorwosid Gunduz, Oguzhan/E-5292-2011
dc.contributor.author Topsakal, Aysenur
dc.contributor.author Midha, Swati
dc.contributor.author Yuca, Esra
dc.contributor.author Tukay, Ari
dc.contributor.author Sasmazel, Hilal Turkoglu
dc.contributor.author Kalaskar, Deepak M.
dc.contributor.author Gunduz, Oguzhan
dc.contributor.other Metallurgical and Materials Engineering
dc.date.accessioned 2024-07-05T15:21:27Z
dc.date.available 2024-07-05T15:21:27Z
dc.date.issued 2021
dc.department Atılım University en_US
dc.department-temp [Topsakal, Aysenur; Gunduz, Oguzhan] Marmara Univ, Ctr Nanotechnol & Biomat Applicat & Res NBUAM, TR-34722 Istanbul, Turkey; [Topsakal, Aysenur; Gunduz, Oguzhan] Marmara Univ, Fac Technol, Dept Met & Mat Engn, TR-34722 Istanbul, Turkey; [Midha, Swati; Kalaskar, Deepak M.] UCL, UCL Div Surg & Intervent Sci, Royal Free Hosp Campus, Rowland Hill St, London NW3 2PF, England; [Midha, Swati] Jawaharlal Nehru Univ, Special Ctr Nanosci, New Delhi 110067, India; [Yuca, Esra] Yildiz Tech Univ, Dept Mol Biol & Genet Engn, Istanbul, Turkey; [Tukay, Ari; Sasmazel, Hilal Turkoglu] Atilim Univ, Met & Mat Engn Dept, Fac Engn, TR-06830 Ankara, Turkey en_US
dc.description Gunduz, Oguzhan/0000-0002-4926-6489; Kalaskar, Deepak/0000-0002-0576-1816; Gunduz, Oguzhan/0000-0002-9427-7574; Turkoglu Sasmazel, Hilal/0000-0002-0254-4541; TUKAY, Ari Kutlug/0000-0001-9378-2635 en_US
dc.description.abstract Over the years, gold nanoparticles (AuNP) have been widely used in several biomedical applications related to the diagnosis, drug delivery, bio-imaging, photo-thermal therapy and regenerative medicine, owing to their unique features such as surface plasmon resonance, fluorescence and easy surface functionality. Recent studies showed that gold nanoparticles display positive effect on osteogenic differentiation. In line with this effect, 3-Dimesional (3D) scaffolds that can be used in bone tissue were produced by exploiting the properties of gold nanoparticles that increase biocompatibility and support bone tissue development. In addition, ampicillin was added to the scaffolds containing gold nanoparticles as a model drug to improve its antimicrobial properties. The scaffolds were produced as composites of polyvinyl alcohol (PVA) main matrix as PVA, PVA/AuNP, PVA/Ampicillin (AMP) and PVA/AuNP/AMP. Scanning Electron Microscopy (SEM) Fourier Transform Infrared Spectroscopy (FTIR), tensile measurement tests, and in vitro applications of 3D scaffolds were performed. As depicted by SEM, scaffolds were produced at pore sizes appropriate for bone tissue regeneration. According to FTIR results, there was no modification observed in the AMP, PVA and gold nanoparticles due to mixing in the resultant scaffolds. In vitro results show that 3D printed composite scaffold based on PVA/AuNP/AMP are biocompatible, osteo-inductive and exhibit antimicrobial properties, compared to PVA scaffolds. This study has implications for addressing infections during orthopedic surgeries. The PVA-based gold nanoparticle 3D tissue scaffold study containing ampicillin covers a new study compared to other articles based on gold nanoparticles. en_US
dc.description.sponsorship BAPKO project, Turkey [FEN-B-121218-0614]; UKIERI project [547073]; DST project, Govt. of India [DST/INSPIRE/04/2017/000645] en_US
dc.description.sponsorship AT would like to thank funding by BAPKO project, Turkey (FEN-B-121218-0614) for funding this research. DMK would like to thank UKIERI project (547073) for collaborative work. SM is supported by DST project, Govt. of India (DST/INSPIRE/04/2017/000645) . en_US
dc.identifier.citationcount 21
dc.identifier.doi 10.1016/j.mtcomm.2021.102458
dc.identifier.issn 2352-4928
dc.identifier.scopus 2-s2.0-85107831382
dc.identifier.scopusquality Q2
dc.identifier.uri https://doi.org/10.1016/j.mtcomm.2021.102458
dc.identifier.uri https://hdl.handle.net/20.500.14411/2088
dc.identifier.volume 28 en_US
dc.identifier.wos WOS:000696949700002
dc.identifier.wosquality Q2
dc.institutionauthor Şaşmazel, Hilal Türkoğlu
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 38
dc.subject Gold nanoparticle en_US
dc.subject PVA en_US
dc.subject Ampicillin en_US
dc.subject 3D printing en_US
dc.subject Bone tissue engineering en_US
dc.title Study on the Cytocompatibility, Mechanical and Antimicrobial Properties of 3d Printed Composite Scaffolds Based on Pva/ Gold Nanoparticles (aunp)/ Ampicillin (amp) for Bone Tissue Engineering en_US
dc.type Article en_US
dc.wos.citedbyCount 29
dspace.entity.type Publication
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