From Nutrition To Medicine: Assessing Hemorrhoid Healing Activity of Solanum Melongena L. Via in Vivo Experimental Models and Its Major Chemicals

dc.authorscopusid 57211062728
dc.authorscopusid 7003580263
dc.authorscopusid 57218294026
dc.authorscopusid 6602104436
dc.authorscopusid 23096992900
dc.authorscopusid 56569492900
dc.authorscopusid 6603041878
dc.contributor.author Dönmez,C.
dc.contributor.author Yalçın,F.N.
dc.contributor.author Boyacıoğlu,Ö.
dc.contributor.author Korkusuz,P.
dc.contributor.author Akkol,E.K.
dc.contributor.author Nemutlu,E.
dc.contributor.author Çalışkan,U.K.
dc.contributor.other Basic Sciences
dc.date.accessioned 2024-07-05T15:45:52Z
dc.date.available 2024-07-05T15:45:52Z
dc.date.issued 2020
dc.department Atılım University en_US
dc.department-temp Dönmez C., Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara, 06330, Turkey, Department of Pharmacognosy, Faculty of Pharmacy, Izmir Katip Celebi University, Izmir, 35620, Turkey; Yalçın F.N., Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, Ankara, 06100, Turkey; Boyacıoğlu Ö., Bioengineering Department, Graduate School of Science and Engineering, Hacettepe University, Ankara, 06800, Turkey, Department of Medical Biochemistry, Basic Sciences Division, Faculty of Medicine, Atılım University, Ankara, 06830, Turkey; Korkusuz P., Department of Histology and Embryology, Faculty of Medicine, Hacettepe University, Ankara, 06100, Turkey; Akkol E.K., Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara, 06330, Turkey; Nemutlu E., Department of Analytical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, 06100, Turkey; Balaban Y.H., Department of Gastroenterology, Faculty of Medicine, Hacettepe University, Ankara, 06100, Turkey; Çalışkan U.K., Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara, 06330, Turkey en_US
dc.description.abstract Ethnopharmacological relevance: Solanum melongena L. (eggplant) is used for treatment of rheumatism, beriberi, itching, toothache, bleeding, asthma, bronchitis, cholera, neuralgia and hemorrhoids in traditional medicine (Turkish, Chinese, and Indian). Hemorrhoids from these diseases, are common illness in all over the world, which are treated with various approaches including ethnobotanicals. Aim of the study: This study aimed to evaluate the anti-hemorrhoidal activity of eggplant, an edible plant, which is commonly utilized around the world. Materials & methods: In vivo anti-hemorrhoidal activity of the methanolic extract prepared from eggplant was evaluated by experimental hemorrhoid model, subsequently histological and biochemical analysis. Hemorrhoid, which was induced by applying croton oil to the anal area of the rats. Furthermore, the extract was screened for anti-inflammatory activity which is based on the inhibition of acetic acid-induced increase in capillary permeability. The healing potential was comparatively assessed with a reference Pilex® tablet and cream. Phytochemical analysis performed by HPLC. The amount of the major phenolic compound (chlorogenic acid) in extract was found by using HPLC method. Results: Histological and biochemical analysis demonstrated that eggplant extract is highly effective against hemorrhoid in comparison to the controls and the commercial preparation. In addition, the methanolic extract demonstrated significant inhibitory effect on acetic acid-induced increase in capillary permeability. The phytochemical studies identified major compound as chlorogenic acid (2.86%) by liquid chromatography. Conclusion: The eggplant calyxes, not edible, are easy to reach, by products/vast from the food sources. This is the first scientific evidence revealing that the eggplant extract has significant anti-hemorrhoidal and anti-inflammatory activity. © 2020 Elsevier B.V. en_US
dc.description.sponsorship Gazi Üniversitesi en_US
dc.identifier.citationcount 7
dc.identifier.doi 10.1016/j.jep.2020.113143
dc.identifier.issn 0378-8741
dc.identifier.pmid PubMed:32687958
dc.identifier.scopus 2-s2.0-85088660784
dc.identifier.uri https://doi.org/10.1016/j.jep.2020.113143
dc.identifier.uri https://hdl.handle.net/20.500.14411/3955
dc.identifier.volume 261 en_US
dc.identifier.wosquality Q1
dc.institutionauthor Boyacıoğlu, Özge
dc.language.iso en en_US
dc.publisher Elsevier Ireland Ltd en_US
dc.relation.ispartof Journal of Ethnopharmacology en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 11
dc.subject Eggplant en_US
dc.subject Ethnopharmacology en_US
dc.subject Hemorrhoid en_US
dc.subject Inflammation en_US
dc.subject Medicinal food en_US
dc.subject Phytochemistry en_US
dc.subject Solanaceae en_US
dc.subject Solanum melongena en_US
dc.title From Nutrition To Medicine: Assessing Hemorrhoid Healing Activity of Solanum Melongena L. Via in Vivo Experimental Models and Its Major Chemicals en_US
dc.type Article en_US
dspace.entity.type Publication
relation.isAuthorOfPublication eec3b848-b659-4208-b834-1a47762239d1
relation.isAuthorOfPublication.latestForDiscovery eec3b848-b659-4208-b834-1a47762239d1
relation.isOrgUnitOfPublication c6d3b3b7-f103-4779-9789-92b2e2420f2d
relation.isOrgUnitOfPublication.latestForDiscovery c6d3b3b7-f103-4779-9789-92b2e2420f2d

Files

Collections