Controlled Gene Delivery Systems: Nanomaterials and Chemical Approaches

dc.authorid Hamblin, Michael R/0000-0001-6431-4605
dc.authorid Fatahi, Yousef/0000-0003-0374-2141
dc.authorid Rabiee, Mohammad/0000-0003-1180-8729
dc.authorid Karimi/0000-0002-7977-3940
dc.authorid Rabiee, Navid/0000-0002-6945-8541
dc.authorid Nasseri, Behzad/0000-0003-3634-8327
dc.authorwosid Hamblin, Mike/AAB-2511-2022
dc.authorwosid Hamblin, Michael R/H-2758-2019
dc.authorwosid Bagherzadeh, Mojtaba/ABC-2351-2020
dc.authorwosid Fatahi, Yousef/S-6193-2016
dc.authorwosid Rabiee, Mohammad/L-9865-2018
dc.authorwosid Karimi/F-8405-2017
dc.authorwosid Rabiee, Navid/K-4407-2019
dc.contributor.author Ahmadi, Sepideh
dc.contributor.author Rabiee, Navid
dc.contributor.author Fatahi, Yousef
dc.contributor.author Bagherzadeh, Mojtaba
dc.contributor.author Gachpazan, Meysam
dc.contributor.author Baheiraei, Nafiseh
dc.contributor.author Hamblin, Michael R.
dc.date.accessioned 2024-07-05T15:38:36Z
dc.date.available 2024-07-05T15:38:36Z
dc.date.issued 2020
dc.department Atılım University en_US
dc.department-temp [Ahmadi, Sepideh] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Dept Med Biotechnol, Student Res Comm, Tehran 1985717443, Iran; [Ahmadi, Sepideh] Shahid Beheshti Univ Med Sci, Cellutar & Mol Biol Res Ctr, Tehran 1985717443, Iran; [Rabiee, Navid; Bagherzadeh, Mojtaba] Sharif Univ Technol, Dept Chem, Tehran 111553516, Iran; [Fatahi, Yousef] Univ Tehran Med Sci, Fac Pharm, Dept Pharmaceut Nanotechnol, Tehran 1417653911, Iran; [Fatahi, Yousef] Univ Tehran Med Sci, Fac Pharm, Nanotechnol Res Ctr, Tehran 1417653911, Iran; [Fatahi, Yousef] Universal Sci Educ & Res Network USERN, Tehran 1417653911, Iran; [Gachpazan, Meysam] Mashhad Univ Med Sci, Sch Med, Dept Med Genet & Mol Med, Mashhad 9177948564, Razavi Khorasan, Iran; [Baheiraei, Nafiseh] Tarbiat Modares Univ, Fac Med Sci, Dept Hematol, Tissue Engn & Appl Cell Sci Div, Tehran 1411713116, Iran; [Nasseri, Behzad] Hacettepe Univ, Chem Engn Dept, TR-06800 Ankara, Turkey; [Nasseri, Behzad] Hacettepe Univ, Bioengn Div, TR-06800 Ankara, Turkey; [Nasseri, Behzad] Atilim Univ, Dept Chem Engn & Appl Chem, TR-06830 Ankara, Turkey; [Karimi, Mahdi] Iran Univ Med Sci, Cellular & Mol Res Ctr, Tehran 14665354, Iran; [Karimi, Mahdi] Iran Univ Med Sci, Fac Adv Technol Med, Dept Med Nanotechnol, Tehran 14665354, Iran; [Karimi, Mahdi] Iran Univ Med Sci, Oncopathol Res Ctr, Tehran 14665354, Iran; [Karimi, Mahdi] Univ Tehran Med Sci, Res Ctr Sci & Technol Med, Tehran 1417653911, Iran; [Karimi, Mahdi] Islamic Azad Univ, Appl Biotechnol Res Ctr, Tehran Med Sci, Tehran 1916893813, Iran; [Karimi, Mahdi; Hamblin, Michael R.] Harvard Med Sch, Wellman Ctr Photomed, Massachusetts Gen Hosp, Boston, MA 02114 USA; [Webster, Thomas J.] Northeastern Univ, Dept Chem Engn, Boston, MA 02115 USA; [Hamblin, Michael R.] Harvard Med Sch, Dept Dermatol, Boston, MA 02115 USA; [Hamblin, Michael R.] Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA en_US
dc.description Hamblin, Michael R/0000-0001-6431-4605; Fatahi, Yousef/0000-0003-0374-2141; Rabiee, Mohammad/0000-0003-1180-8729; Karimi/0000-0002-7977-3940; Rabiee, Navid/0000-0002-6945-8541; Nasseri, Behzad/0000-0003-3634-8327 en_US
dc.description.abstract Successful gene therapy depends on the design of effective gene delivery systems. A gene delivery system is considered a powerful tool for the release of genetic material within cells resulting in a change in cell functions and protein production. The release of genes in a controlled manner by using appropriate carriers facilitates their release without side effects and increases the expression of genes at the released site. It is expected that significant changes in the combination of several genes and drugs can be provided by developing treatment systems sensitive to different stimuli such as redox potential, pH variations, temperature gradients, light irradiation, and enzyme activity. The most important advantages for the release of genes and stimuli-responsive therapeutics include delivering vectors locally, reducing side effects and causing no toxicity to distant tissues while at the same time reducing the immune response to the vectors. In this review, we aim to discuss different types of gene carriers involved in the controlled transfer of nucleic acids (non-viral inorganic and organic nanoparticles (NPs) and virus-like particles (VLPs)) as well as the simultaneous transfer of several genes and/or drugs into cells or different tissues, providing for an efficient and safe treatment of numerous diseases. en_US
dc.identifier.citationcount 20
dc.identifier.doi 10.1166/jbn.2020.2927
dc.identifier.endpage 582 en_US
dc.identifier.issn 1550-7033
dc.identifier.issn 1550-7041
dc.identifier.issue 5 en_US
dc.identifier.pmid 32919478
dc.identifier.scopusquality Q3
dc.identifier.startpage 553 en_US
dc.identifier.uri https://doi.org/10.1166/jbn.2020.2927
dc.identifier.uri https://hdl.handle.net/20.500.14411/3130
dc.identifier.volume 16 en_US
dc.identifier.wos WOS:000573055000001
dc.identifier.wosquality Q3
dc.language.iso en en_US
dc.publisher Amer Scientific Publishers en_US
dc.relation.publicationcategory Diğer en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Nanomedicine en_US
dc.subject Controlled Release of Genes en_US
dc.subject Gene Therapy en_US
dc.subject Non-Viral Vectors en_US
dc.subject Viral Vectors en_US
dc.title Controlled Gene Delivery Systems: Nanomaterials and Chemical Approaches en_US
dc.type Review en_US
dc.wos.citedbyCount 21
dspace.entity.type Publication

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