Semi-IPN Chitosan/PEG Microspheres and Films for Biomedical Applications: Characterization and Sustained Release Optimization

Abstract

Micro drug carriers are one of the efficient methods for local or systemic cancer treatment. In this study, the aim was to prepare a novel semi-interpenetrated (semi-IPN) micro system by using biocompatible chitosan (CH) and polyethylene glycol (PEG). Various combinations of the systems were prepared and loaded with a model chemotherapeutic drug, methotrexate (MTX), and the effects of composition on the properties and the release behavior of microspheres were examined. Also, the mechanical and thermal properties were examined on film forms of similar compositions. Increase in cross-linking caused a decrease in particle size of CH from 144 to 91 mu m, while the addition of PEG caused an increase up to 163 mu m. Elastic modulus values of the films first increased and then decreased parallel to PEG content. In vitro studies showed faster MTX release from semi-IPN CH-PEG microspheres as compared to pure CH ones. Promising results were obtained in the development of biodegradable drug vehicles.