Evaluation of the Relationship Between Dietary Acid Load and Cardiovascular Risk Factors in Patients With Type 2 Diabetes: a Case-Control Study

dc.authorscopusid 59305531600
dc.authorscopusid 55001881000
dc.contributor.author Gungor, Sedef
dc.contributor.author Saka, Mendane
dc.contributor.other Nutrition and Dietetics
dc.date.accessioned 2024-09-10T21:33:37Z
dc.date.available 2024-09-10T21:33:37Z
dc.date.issued 2024
dc.department Atılım University en_US
dc.department-temp [Gungor, Sedef] Atilim Univ, Fac Hlth Sci, Dept Nutr & Dietet, Ankara, Turkiye; [Saka, Mendane] Baskent Univ, Fac Hlth Sci, Dept Nutr & Dietet, Ankara, Turkiye en_US
dc.description.abstract Backround Diets high in dietary acid load are thought to be associated with metabolic diseases. However, the number of studies examining the relationship between dietary acid load and metabolic diseases in Turkey is insufficient. The aim of this study was to investigate the relationship between cardiovascular disease risk factors and dietary acid load in individuals with type 2 diabetes.Materials and methods In this case-control study, 51 participants aged 30-65 years with type 2 diabetes and 59 participants in the control group were included. Blood pressure and biochemical findings were measured. Anthropometric measurements and body composition measurements were made. Dietary intake was assessed using a 3-day (1 day on weekends, 2 days on weekdays) food consumption record. Dietary acid load scores, including potential renal acid load (PRAL) and net endogenous acid production (NEAP), were calculated based on dietary intake. NEAP and PRAL scores were categorized as low and high according to the median value. Smoking status, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), trigylceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL), waist-hip ratio (WHR), waist-to- height ratio (WtHR), hemoglobin and fat mass (%) were evaluated as cardiovascular risk factors.Results The cut-off values of PRAL and NEAP were 3.61 and 44.78 mEq/d, respectively. After adjustment for various covariates, a significant positive association between PRAL and TG levels was observed in the diabetic group [odds ratio (OR), 5.98; 95% CI, 1.45-24.67; p = 0.013]. In contrast, a negative association was found between PRAL and SBP in the control group [odds ratio (OR), 0.21; 95% CI, 0.05-0.83; p = 0.026]. However, these associations were not observed for NEAP values in either group.Conslusions A higher PRAL value was consistently associated with higher TG level, but other cardiovascular risk factors were not. More longitudinal and interventional studies are needed to better establish a causal effect between dietary acid load and cardiovascular risk factors in individuals with diabetes. en_US
dc.description.sponsorship Bascedil;kent University Research Fund en_US
dc.description.sponsorship The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This study was supported by Ba & scedil;kent University Research Fund. DAS:The datasets presented in this article are not readily available because of privacy or ethical restrictions. Requests to access the datasets should be directed to SG, sedef.gungor@atilim.edu.tr. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.citationcount 0
dc.identifier.doi 10.3389/fnut.2024.1445933
dc.identifier.issn 2296-861X
dc.identifier.scopus 2-s2.0-85202594171
dc.identifier.scopusquality Q2
dc.identifier.uri https://doi.org/10.3389/fnut.2024.1445933
dc.identifier.uri https://hdl.handle.net/20.500.14411/7297
dc.identifier.volume 11 en_US
dc.identifier.wos WOS:001299361000001
dc.identifier.wosquality Q2
dc.institutionauthor Güngör, Sedef
dc.language.iso en en_US
dc.publisher Frontiers Media Sa en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 0
dc.subject cardiovascular disease en_US
dc.subject dietary acid load en_US
dc.subject type 2 diabetes en_US
dc.subject potential renal acid load en_US
dc.subject net endogenous acid production en_US
dc.title Evaluation of the Relationship Between Dietary Acid Load and Cardiovascular Risk Factors in Patients With Type 2 Diabetes: a Case-Control Study en_US
dc.type Article en_US
dc.wos.citedbyCount 0
dspace.entity.type Publication
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relation.isAuthorOfPublication.latestForDiscovery 0834b978-ad98-411c-968e-3e6f06f108b5
relation.isOrgUnitOfPublication 2071c428-f13d-4e73-b6f2-9902e8f00103
relation.isOrgUnitOfPublication.latestForDiscovery 2071c428-f13d-4e73-b6f2-9902e8f00103

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