Özkan, Akın

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https://hdl.handle.net/20.500.14411/7674
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Ö.,Akın
Özkan,A.
Akin, Ozkan
Akın, Özkan
A.,Özkan
Ozkan,A.
A.,Ozkan
O.,Akin
O., Akin
A., Ozkan
Özkan, Akın
Ozkan, Akin
Job Title
Araştırma Görevlisi
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akin.ozkan@atilim.edu.tr
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Department of Electrical & Electronics Engineering
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Former Staff
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Scholarly Output

10

Articles

3

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2/0

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1

Supervised PhD Theses

1

WoS Citation Count

26

Scopus Citation Count

38

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WoS Citations per Publication

2.60

Scopus Citations per Publication

3.80

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4

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2

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2011 IEEE 19th Signal Processing and Communications Applications Conference, SIU 2011 -- 2011 IEEE 19th Signal Processing and Communications Applications Conference, SIU 2011 -- 20 April 2011 through 22 April 2011 -- Antalya -- 855281
2016 24th Signal Processing and Communication Application Conference, SIU 2016 - Proceedings -- 24th Signal Processing and Communication Application Conference, SIU 2016 -- 16 May 2016 through 19 May 2016 -- Zonguldak -- 1226051
24th Signal Processing and Communication Application Conference (SIU) -- MAY 16-19, 2016 -- Zonguldak, TURKEY1
25th IEEE International Conference on Image Processing (ICIP) -- OCT 07-10, 2018 -- Athens, GREECE1
Biomedical Research (India)1
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Author: Isgor, Yasemin GulgunSubject: hemocytometer

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    Article
    Citation - WoS: 9
    Citation - Scopus: 9
    Benchmarking Classification Models for Cell Viability on Novel Cancer Image Datasets
    (Bentham Science Publ Ltd, 2019) Ozkan, Akin; Isgor, Sultan Belgin; Sengul, Gokhan; Isgor, Yasemin Gulgun
    Background: Dye-exclusion based cell viability analysis has been broadly used in cell biology including anticancer drug discovery studies. Viability analysis refers to the whole decision making process for the distinction of dead cells from live ones. Basically, cell culture samples are dyed with a special stain called trypan blue, so that the dead cells are selectively colored to darkish. This distinction provides critical information that may be used to expose influences of the studied drug on considering cell culture including cancer. Examiner's experience and tiredness substantially affect the consistency throughout the manual observation of cell viability. The unsteady results of cell viability may end up with biased experimental results accordingly. Therefore, a machine learning based automated decision-making procedure is inevitably needed to improve consistency of the cell viability analysis. Objective: In this study, we investigate various combinations of classifiers and feature extractors (i.e. classification models) to maximize the performance of computer vision-based viability analysis. Method: The classification models are tested on novel hemocytometer image datasets which contain two types of cancer cell images, namely, caucasian promyelocytic leukemia (HL60), and chronic myelogenous leukemia (K562). Results: From the experimental results, k-Nearest Neighbor (KNN) and Random Forest (RF) by combining Local Phase Quantization (LPQ) achieve the lowest misclassification rates that are 0.031 and 0.082, respectively. Conclusion: The experimental results show that KNN and RF with LPQ can be powerful alternatives to the conventional manual cell viability analysis. Also, the collected datasets are released from the "biochem.atilim.edu.tr/datasets/ " web address publically to academic studies.