Dursun, Ali Doğan

Now showing 1 - 2 of 2

Effectiveness of Boric Acid in Sepsis in Rats With Cecal Perforation
(Springer Nature, 2025) Kurtipek, Ali Can; Dursun, Ali Dogan; Yigman, Zeynep; Ozdemir, Cagri; Kucuk, Aysegul; Gonullu, Ugur; Arslan, Mustafa
Introduction and AimSepsis is a systemic inflammatory response that develops in the host against microorganisms, which results in end-organ damage. Boric acid (BA) has been shown to have immune modulatory effects in vitro and in animal studies. The aim of the study is to investigate the effects of high dose BA on lung and kidney tissues in rats with sepsis induced by the CLP method.Method28 rats were randomly divided into four groups: Group C (control group), Group BA, Group CLP (cecal ligation and puncture), and Group CLP + BA. Cecum was ligated below the ileocecal valve and punctured. BA was administered to the treatment groups at an intraperitoneal dose of 200 mg/kg, and at the end of 24 h, lung and kidney tissue samples were collected and evaluated for biochemical and histopathological parameters.ResultsHistopathologically, in kidney tissue, CLP + BA group showed significantly less peritubular capillary dilatation and brush border loss in the proximal tubule epithelium compared to the CLP group. In lung tissue, CLP + BA group had significantly less alveolar wall thickening compared to the CLP group. Biochemical analyses indicated that BA administration reduced oxidative stress in both renal and lung tissues.ConclusionWe found that intraperitoneal administration of high dose boric acid partially ameliorated the tissue damage in rats subjected to CLP induced sepsis. Further studies are needed regarding the dosage and application at different time points.
Effects of Pregabalin on Kidney Tissue in Spinal Cord Ischemia Reperfusion Injured Rats;
(Gazi Universitesi, 2021) Ceran,E.U.; Inan,N.; Kucuk,A.; Ozer,A.; Dursun,A.D.; Tosun,M.; Arslan,M.
Objectives: The purpose of this study was to investigate the possible protective effects of low and high dose pregabalin that was administered in rat in a spinal cord ischemia-reperfusion (I/R) study model. Material and Method: We used 24 Wistar albino rats as subjects in our study. They were divided into 4 groups; randomized Control (C group), I/R (I/R group), I/R-low dose (30 mg/kg) pregabalin (I/R-LP group) and I/R-high dose (200 mg/kg) pregabalin (I/R-HP group). All groups have undergone a laparotomy intervention under anesthesia. In I/R group, a cross clamp was placed in the abdominal aorta just after the laparotomy for 120 minutes (to cause spinal cord ischemia injury) and then reperfusion was achieved by opening the vascular clamp. At the end of the study, kidney tissue was obtained for determining total oxidant status (TOS) and total antioxidant status (TAS) levels, histochemical and immunohistochemical determination. Results: Total Oxidative Status (TOS) enzyme activity was significantly higher in I/R group when compared to the control, I/R-LP and I/R-HP groups. Likewise, Total Antioxidant Status (TAS) enzyme activity was remarkably higher in I/R group when compared with the C, I/R-LP and I/R-HP groups. VEGF staining has yielded no expression in renal tissues. In microscopical analysis of the tissue slides which were immunohistochemically stained with p53 antibody, some crucial findings have been established as follows: As p53-expressing cells were not detected in the control group, the presence of p53-expressing cells were clearly identified at different intensities in several bowman capsules in the I/R group. However, no expression was detected in general tubules. Interestingly, p53 expression levels were prominently lower in low-dose pregabalin given group and considerably higher in the 200 mg/kg pregabalin administered group, which was more pronounced than the I/R group. Conclusion: Results established from the current study suggest that pregabalin given at different doses may have a partial protective effect in kidney tissues of rats undergone experimental spinal cord IR injury. ©Copyright 2021 by Gazi University Medical Faculty

Journal	Count
International Journal of General Medicine	4
Drug Design, Development and Therapy	3
Medicina	3
Gazi Medical Journal	2
Bratislava Medical Journal	2

Dursun, Ali Doğan

Profile URL

Name Variants

Job Title

Email Address

Main Affiliation

Status

Website

ORCID ID

Scopus Author ID

Turkish CoHE Profile ID

Google Scholar ID

WoS Researcher ID

Sustainable Development Goals

5

GENDER EQUALITY

1

Research Products

14

LIFE BELOW WATER

2

Research Products

10

REDUCED INEQUALITIES

0

Research Products

3

GOOD HEALTH AND WELL-BEING

17

Research Products

2

ZERO HUNGER

0

Research Products

9

INDUSTRY, INNOVATION AND INFRASTRUCTURE

1

Research Products

16

PEACE, JUSTICE AND STRONG INSTITUTIONS

1

Research Products

11

SUSTAINABLE CITIES AND COMMUNITIES

0

Research Products

8

DECENT WORK AND ECONOMIC GROWTH

0

Research Products

13

CLIMATE ACTION

0

Research Products

4

QUALITY EDUCATION

0

Research Products

6

CLEAN WATER AND SANITATION

1

Research Products

1

NO POVERTY

0

Research Products

15

LIFE ON LAND

0

Research Products

17

PARTNERSHIPS FOR THE GOALS

0

Research Products

7

AFFORDABLE AND CLEAN ENERGY

1

Research Products

12

RESPONSIBLE CONSUMPTION AND PRODUCTION