Dursun, Ali Doğan

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https://hdl.handle.net/20.500.14411/6899
Name Variants
Dursun, Ali D. D.
D. Dursun
D.,Ali Dogan
Dursun A.
A., Dursun
Dursun, Ali
Ali Doan
Dursun, Ali Dogan
Dursun, A. D.
A.,Dursun
Dursun,A.D.
D., Ali Doğan
Dursun, Ali Doğan
D.,Ali Doğan
A.D.Dursun
Ali Doğan, Dursun
A. D. Dursun
Dursun, Ali D.
Ali Dogan, Dursun
D., Ali Dogan
Job Title
Doçent Doktor
Email Address
ali.dursun@atilim.edu.tr
Main Affiliation
Basic Sciences
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Website
ORCID ID
0000-0001-9056-0025
Scopus Author ID
57196954194
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID
AAH-7617-2019

Sustainable Development Goals

NO POVERTY1
NO POVERTY
0
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ZERO HUNGER2
ZERO HUNGER
0
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GOOD HEALTH AND WELL-BEING3
GOOD HEALTH AND WELL-BEING
21
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QUALITY EDUCATION4
QUALITY EDUCATION
0
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GENDER EQUALITY5
GENDER EQUALITY
1
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CLEAN WATER AND SANITATION6
CLEAN WATER AND SANITATION
2
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AFFORDABLE AND CLEAN ENERGY7
AFFORDABLE AND CLEAN ENERGY
1
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DECENT WORK AND ECONOMIC GROWTH8
DECENT WORK AND ECONOMIC GROWTH
0
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INDUSTRY, INNOVATION AND INFRASTRUCTURE9
INDUSTRY, INNOVATION AND INFRASTRUCTURE
1
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REDUCED INEQUALITIES10
REDUCED INEQUALITIES
0
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SUSTAINABLE CITIES AND COMMUNITIES11
SUSTAINABLE CITIES AND COMMUNITIES
1
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RESPONSIBLE CONSUMPTION AND PRODUCTION12
RESPONSIBLE CONSUMPTION AND PRODUCTION
0
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CLIMATE ACTION13
CLIMATE ACTION
0
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LIFE BELOW WATER14
LIFE BELOW WATER
2
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LIFE ON LAND15
LIFE ON LAND
0
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PEACE, JUSTICE AND STRONG INSTITUTIONS16
PEACE, JUSTICE AND STRONG INSTITUTIONS
1
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PARTNERSHIPS FOR THE GOALS17
PARTNERSHIPS FOR THE GOALS
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Documents

71

Citations

553

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Scholarly Output

50

Articles

47

Views / Downloads

144/63

Supervised MSc Theses

1

Supervised PhD Theses

0

WoS Citation Count

285

Scopus Citation Count

304

Patents

0

Projects

0

WoS Citations per Publication

5.70

Scopus Citations per Publication

6.08

Open Access Source

31

Supervised Theses

1

JournalCount
International Journal of General Medicine4
Drug Design, Development and Therapy4
Medicina3
Talanta2
Journal of Updates in Cardiovascular Medicine2
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Author: Ozdemir, Cagri

Scholarly Output Search Results

Now showing 1 - 6 of 6
  • Thumbnail Image
    Article
    Effectiveness of Boric Acid in Sepsis in Rats With Cecal Perforation
    (Springer Nature, 2025) Kurtipek, Ali Can; Dursun, Ali Dogan; Yigman, Zeynep; Ozdemir, Cagri; Kucuk, Aysegul; Gonullu, Ugur; Arslan, Mustafa
    Introduction and AimSepsis is a systemic inflammatory response that develops in the host against microorganisms, which results in end-organ damage. Boric acid (BA) has been shown to have immune modulatory effects in vitro and in animal studies. The aim of the study is to investigate the effects of high dose BA on lung and kidney tissues in rats with sepsis induced by the CLP method.Method28 rats were randomly divided into four groups: Group C (control group), Group BA, Group CLP (cecal ligation and puncture), and Group CLP + BA. Cecum was ligated below the ileocecal valve and punctured. BA was administered to the treatment groups at an intraperitoneal dose of 200 mg/kg, and at the end of 24 h, lung and kidney tissue samples were collected and evaluated for biochemical and histopathological parameters.ResultsHistopathologically, in kidney tissue, CLP + BA group showed significantly less peritubular capillary dilatation and brush border loss in the proximal tubule epithelium compared to the CLP group. In lung tissue, CLP + BA group had significantly less alveolar wall thickening compared to the CLP group. Biochemical analyses indicated that BA administration reduced oxidative stress in both renal and lung tissues.ConclusionWe found that intraperitoneal administration of high dose boric acid partially ameliorated the tissue damage in rats subjected to CLP induced sepsis. Further studies are needed regarding the dosage and application at different time points.
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    Article
    Citation - WoS: 4
    Citation - Scopus: 4
    Effects of Cerium Oxide on Kidney and Liver Tissue Damage in an Experimental Myocardial Ischemia-Reperfusion Model of Distant Organ Damage
    (Mdpi, 2024) Gunes, Isin; Dursun, Ali Dogan; Ozdemir, Cagri; Kucuk, Aysegul; Sezen, Saban Cem; Arslan, Mustafa; Ozer, Abdullah
    Background and Objectives: Ischemia-reperfusion (I/R) injury is a process in which impaired perfusion is restored by restoring blood flow and tissue recirculation. Nanomedicine uses cutting-edge technologies that emerge from interdisciplinary influences. In the literature, there are very few in vivo and in vitro studies on how cerium oxide (CeO2) affects systemic anti-inflammatory response and inflammation. Therefore, in our study, we aimed to investigate whether CeO2 administration has a protective effect against myocardial I/R injury in the liver and kidneys. Materials and Methods: Twenty-four rats were randomly divided into four groups after obtaining approval from an ethics committee. A control (group C), cerium oxide (group CO), IR (group IR), and Cerium oxide-IR (CO-IR group) groups were formed. Intraperitoneal CeO2 was administered at a dose of 0.5 mg/kg 30 min before left thoracotomy and left main coronary (LAD) ligation, and myocardial muscle ischemia was induced for 30 min. After LAD ligation was removed, reperfusion was performed for 120 min. All rats were euthanized using ketamine, and blood was collected. Liver and kidney tissue samples were evaluated histopathologically. Serum AST (aspartate aminotransferase), ALT (alanine aminotransaminase), GGT (gamma-glutamyl transferase), glucose, TOS (Total Oxidant Status), and TAS (Total Antioxidant Status) levels were also measured. Results: Necrotic cell and mononuclear cell infiltration in the liver parenchyma of rats in the IR group was observed to be significantly increased compared to the other groups. Hepatocyte degeneration was greater in the IR group compared to groups C and CO. Vascular vacuolization and hypertrophy, tubular degeneration, and necrosis were increased in the kidney tissue of the IR group compared to the other groups. Tubular dilatation was significantly higher in the IR group than in the C and CO groups. TOS was significantly higher in all groups than in the IR group (p < 0.0001, p < 0.0001, and p = 0.006, respectively). However, TAS level was lower in the IR group than in the other groups (p = 0.002, p = 0.020, and p = 0.031, respectively). Renal and liver histopathological findings decreased significantly in the CO-IR group compared to the IR group. A decrease in the TOS level and an increase in the TAS level were found compared to the IR group. The AST, ALT, GGT, and Glucose levels are shown. Conclusions: CeO2 administered before ischemia-reperfusion reduced oxidative stress and ameliorated IR-induced damage in distant organs. We suggest that CeO2 exerts protective effects in the myocardial IR model.
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    Article
    Citation - WoS: 12
    Citation - Scopus: 17
    Therapeutic Efficacy of Boric Acid Treatment on Brain Tissue and Cognitive Functions in Rats With Experimental Alzheimer's Disease
    (Dove Medical Press Ltd, 2023) Ozdemir, Cagri; Arslan, Mustafa; Kucuk, Aysegul; Yigman, Zeynep; Dursun, Ali Dogan
    Introduction: Oxidative stress has an important role in the pathophysiology of Alzheimer's disease (AD), the most common type of dementia. Boric acid (BA) contributes significantly to the protection of the brain by reducing lipid peroxidation and supporting antioxidant defense. We aimed to evaluate the therapeutic potential of BA treatment in AD rats. Materials and Methods: Four groups were formed as Control (C), Alzheimer's (A), Alzheimer's + Boric acid (ABA), Boric acid (BA). Intracerebroventricular injection of Streptozotocin (STZ) was preferred to create an AD. After 4 weeks, BA was applied 3 times every other day. The Radial Arm Maze Test (RAMT) was used to evaluate memory and learning abilities. Biochemical and histopathological evaluations were made in the hippocampus. Results: Initial RAMT inlet/outlet (I/O) numbers were similar. Two weeks after STZ injection, I/O numbers decreased in group A and ABA compared to group C and BA (p<0.05). After the second BA application, I/O numbers increased in the ABA group compared to the A group (p<0.05). In group A, PON-1, TOS and OSI levels were higher and TAS levels were lower than in groups BA and C. After BA treatment, PON-1 and OSI levels were lower in the ABA group than in the A group (p<0.05). Although there was an increase in TAS value and a decrease in TOS, this did not make a statistical difference. The thickness of the pyramidal cell in CA1 and the granular cell layers in the dentate gyrus, and the number of intact and degenerated neurons in the pyramidal cell layer were similar between the groups. Discussion: Significant improvement in learning and memory abilities after BA application is promising for AD. Conclusion: These results show that BA application positively affects learning and memory abilities, and reduces oxidative stress. More extensive studies are required to evaluate histopathological efficacy.
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    Conference Object
    The Effect of Different Doses Apelin 13 on Erythrocyte Deformability in Rats
    (Wiley, 2019) Dursun, Ali Dogan; Ozdemir, Cagri; Comu, Faruk Metin; Kucuk, Aysegul; Arslan, Mustafa
    [No Abstract Available]
  • Thumbnail Image
    Conference Object
    Investigation of Analgesic Minimum Effective Dose of Apelin-13 With Different Doses of Intraperitoneal Injections and its Effects on Kidney Tissue
    (Wiley, 2020) Dursun, Ali; Ozdemir, Cagri; Sezen, Saban; Kucuk, Aysegul; Arslan, Mustafa
    [No Abstract Available]
  • Thumbnail Image
    Article
    Farklı Dozlarda Uygulanan Apelin-13’ün Analjezik Minimum Etkin Dozu ve Böbrek Dokusu Üzerine Etkisi: Deneysel Çalışma
    (2024) Küçük, Ayşegül; Dursun, Alı Dogan; Arslan, Mustafa; Ozdemir, Cagri; Sezen, Şaban Cem
    Amaç: Apelin ve APJ sinyal yolu; kalp, böbrek ve akciğer dâhil çeşitli dokularda eksprese edilmektedir. Bu yol kan bas ıncı, kardiyak kontraktilite, kalp h ızı, nosisepsiyon, apoptozis ve inflamasyon üzerinde çeşitli etkilere sahiptir. Mekanizması hâlen anlaşılamamasına rağmen Apelin-13’ün analjezik etkinli ği gösterilmi ştir. Gelecekte koruyucu ve tedavi edici bir ajan olarak kullan ılabilecek olması insan sağlığına önemli katk ılar sağlayacaktır. Bu sebeple ratlarda Apelin- 13’ün minimum analjezik etkin dozunu ve böbrek üzerine etkilerini araştırmayı amaçladık. Gereç ve Yöntemler: 30 adet Wistar Albino erkek rat, randomize olarak 5 gruba ayrıldı. Ratlar kontrol, Apelin-25, Apelin-50, Apelin-100 ve Apelin-200 gruplar ı olarak isimlendirildi. Apelin-13 intraperitoneal olarak 25, 50, 100 ve 200 μg/kg uyguland ı. Kontrol grubuna intraperitoneal olarak ayn ı hacimde salin uygulandı. Apelin uygulanmasından sonra 30. dk, 1. ve 2. saatlerde Hot Plate testi ile analjezik etkinlik de ğerlendirildi. 24 saat sonra histolojik ve biyokimyasal değerlendirmeler için tüm ratlardan kan ve doku örnekleri alındı. Bulgular: Hot Plate sonuçlarına bakıldığında 50 μg/kg ve üzeri Apelin-13’ün analjezik etkinlik gösterdiği tespit edildi. 25 μg/kg dozda analjezik etki görülmedi. 100 ve 200 μg/kg Apelin-13 uygulanan ratların böbrek dokusunda vasküler vakuolizasyon ve hipertrofi, Bowman aralık dilatasyonu ve tübüler hücre dökülmesi anlamlı olarak artmış bulundu. 200 μg/kg Apelin-13 uygulanan ratlarda doku oksidatif stres belirteçleri daha yüksekti. Sonuç: Literatürde Apelin-13’ün farklı dozlarda analjezik etkileri ile ilgili çalışmalara rastlamadık. 200 μg/kg Apelin-13 uygulamas ının böbrek dokusunu olumsuz etkiledi ğini bulduk. Apelin-13’ün minimum analjezik etkin dozunun intraperitoneal olarak uygulanan 50 μg/kg olduğunu tespit ettik.