Boyacıoğlu, Özge

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Profile URL
https://hdl.handle.net/20.500.14411/6667
Name Variants
Boyacioglu,Ozge
Boyacioglu,Ö.
Boyacioglu, Ozge
Özge Boyacıoğlu
B., Özge
Boyacioglu,O.
Ö.,Boyacıoğlu
B.,Özge
Ozge, Boyacioglu
Boyacıoğlu, Özge
Ö., Boyacıoğlu
B.,Ozge
B., Ozge
Boyacioglu O.
O.,Boyacioglu
Boyacıoğlu,Ö.
O., Boyacioglu
Özge, Boyacıoğlu
Boyacioglu, OEzge
Job Title
Araştırma Görevlisi
Email Address
ozge.boyacioglu@atilim.edu.tr
Main Affiliation
Basic Sciences
Status
Website
ORCID ID
0000-0001-5240-8209
Scopus Author ID
57218294026
Turkish CoHE Profile ID
298145
Google Scholar ID
6UIeqH4AAAAJ
WoS Researcher ID
ABG-3552-2020

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NO POVERTY1
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0
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ZERO HUNGER2
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0
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GOOD HEALTH AND WELL-BEING3
GOOD HEALTH AND WELL-BEING
9
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QUALITY EDUCATION4
QUALITY EDUCATION
0
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GENDER EQUALITY5
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0
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CLEAN WATER AND SANITATION6
CLEAN WATER AND SANITATION
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AFFORDABLE AND CLEAN ENERGY7
AFFORDABLE AND CLEAN ENERGY
0
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DECENT WORK AND ECONOMIC GROWTH8
DECENT WORK AND ECONOMIC GROWTH
0
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INDUSTRY, INNOVATION AND INFRASTRUCTURE9
INDUSTRY, INNOVATION AND INFRASTRUCTURE
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REDUCED INEQUALITIES10
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SUSTAINABLE CITIES AND COMMUNITIES11
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0
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RESPONSIBLE CONSUMPTION AND PRODUCTION12
RESPONSIBLE CONSUMPTION AND PRODUCTION
0
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0
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LIFE BELOW WATER14
LIFE BELOW WATER
1
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LIFE ON LAND
0
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PEACE, JUSTICE AND STRONG INSTITUTIONS16
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PARTNERSHIPS FOR THE GOALS17
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Documents

13

Citations

109

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9

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62

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Scholarly Output

13

Articles

9

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0

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0

WoS Citation Count

46

Scopus Citation Count

109

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0

WoS Citations per Publication

3.54

Scopus Citations per Publication

8.38

Open Access Source

3

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0

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Advances in Experimental Medicine and Biology2
Biotechnic & Histochemistry1
Cell Death & Disease1
Comparative Kinesiology of the Human Body: Normal and Pathological Conditions1
International Journal of Biological Macromolecules1
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Subject: ACPA

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    Article
    Citation - WoS: 3
    Citation - Scopus: 3
    Development and Validation of a Sensitive Assay for the Quantification of Arachidonoylcyclopropylamide (acpa) in Cell Culture by Lc-ms/Ms
    (Springer int Publ Ag, 2023) Boyacioglu, Ozge; Recber, Tuba; Kir, Sedef; Korkusuz, Petek; Nemutlu, Emirhan
    Synthetic and natural cannabinoid derivatives are highly investigated as drug candidates due to their antinociceptive, antiepileptic and anticancer potential. Arachidonoylcyclopropylamide (ACPA) is a synthetic cannabinoid with antiproliferative and apoptotic effects on non-small cell lung cancer and pancreatic and endometrial carcinoma. Thus, ACPA has a great potential for being used as an anticancer drug for epithelial cancers. Therefore, determining the levels of ACPA in biological fluids, cells, tissues and pharmaceutical dosage forms is crucial in monitoring the effects of various pharmacological, physiological and pathological stimuli on biological systems. However, the challenge in the quantification of ACPA is its short half-life and lack of UV signal. Therefore, we developed a liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for sensitive and selective quantification of ACPA in cell culture medium and intracellular matrix. Multiple reaction monitoring in the positive ionization mode was used for detection with 344 -> 203 m/z transitions. The separation of ACPA was performed on C18 column (50 x 3.0 mm, 2.1 mu m) with the mobile phase run in the gradient mode with 0.1% formic acid (FA) in water and 0.1% FA in acetonitrile at a flow rate of 0.3 ml/min. The assay was linear in the concentration range of 1.8-1000 ng/mL (r = 0.999). The validation studies revealed that the method was linear, sensitive, accurate, precise, selective, repeatable, robust and rugged. Finally, the developed method was applied to quantify ACPA in cell culture medium and intracellular matrix.