Boyacıoğlu, Özge

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https://hdl.handle.net/20.500.14411/6667
Name Variants
Boyacioglu,Ozge
Boyacioglu,Ö.
Boyacioglu, Ozge
Özge Boyacıoğlu
B., Özge
Boyacioglu,O.
Ö.,Boyacıoğlu
B.,Özge
Ozge, Boyacioglu
Boyacıoğlu, Özge
Ö., Boyacıoğlu
B.,Ozge
B., Ozge
Boyacioglu O.
O.,Boyacioglu
Boyacıoğlu,Ö.
O., Boyacioglu
Özge, Boyacıoğlu
Boyacioglu, OEzge
Job Title
Araştırma Görevlisi
Email Address
ozge.boyacioglu@atilim.edu.tr
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Basic Sciences
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Website
ORCID ID
0000-0001-5240-8209
Scopus Author ID
57218294026
Turkish CoHE Profile ID
298145
Google Scholar ID
6UIeqH4AAAAJ
WoS Researcher ID
ABG-3552-2020

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9
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112

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13

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47

Scopus Citation Count

112

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WoS Citations per Publication

3.62

Scopus Citations per Publication

8.62

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3

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Advances in Experimental Medicine and Biology2
Biotechnic & Histochemistry1
Cell Death & Disease1
Comparative Kinesiology of the Human Body: Normal and Pathological Conditions1
International Journal of Biological Macromolecules1
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Author: Recber, TubaSubject: apoptosis

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    Article
    Citation - WoS: 2
    Citation - Scopus: 2
    Cb65 and Novel Cb65 Liposomal System Suppress Mg63 and Saos-2 Osteosarcoma Cell Growth in Vitro
    (Taylor & Francis Ltd, 2024) Zorba, Basak Isil; Boyacioglu, Oezge; Caglayan, Tugba; Recber, Tuba; Nemutlu, Emirhan; Eroglu, Ipek; Korkusuz, Petek
    Curable approaches for primary osteosarcoma are inadequate and urge investigation of novel therapeutic formulations. Cannabinoid ligands exert antiproliferative and apoptotic effect on osteosarcoma cells via cannabinoid 2 (CB2) or transient receptor potential vanilloid type (TRPV1) receptors. In this study, we confirmed CB2 receptor expression in MG63 and Saos-2 osteosarcoma cells by qRT-PCR and flow cytometry (FCM), then reported the reduction effect of synthetic specific CB2 receptor agonist CB65 on the proliferation of osteosarcoma cells by WST-1 (water-soluble tetrazolium-1) and RTCA (real-time impedance-based proliferation). CB65 revealed an IC50 (inhibitory concentration) for MG63 and Saos-2 cells as 1.11 x 10(-11) and 4.95 x 10(-11) M, respectively. The specific antiproliferative effect of CB65 on osteosarcoma cells was inhibited by CB2 antagonist AM630. CB65 induced late apoptosis of MG63 and Saos-2 cells at 24 and 48 h, respectively by FCM when applied submaximal concentration. A novel CB65 liposomal system was generated by a thin film hydration method with optimal particle size (141.7 +/- 0.6 nm), polydispersity index (0.451 +/- 0.026), and zeta potential (-10.9 +/- 0.3 mV) values. The encapsulation efficiency (EE%) of the CB65-loaded liposomal formulation was 51.12%. The CB65 and CB65-loaded liposomal formulation releasing IC50 of CB65 reduced proliferation by RTCA and invasion by scratch assay and induced late apoptosis of MG63 and Saos-2 cells, by FCM. Our results demonstrate the CB2 receptor-mediated antiproliferative and apoptotic effect of a new liposomal CB65 delivery system on osteosarcoma cells that can be used as a targeted and intelligent tool for bone tumors to ameliorate pediatric bone cancers following in vivo validation.