Aydın, Canset

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https://hdl.handle.net/20.500.14411/6948
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A.,Canset
C., Aydın
Canset, Aydın
C.,Aydin
C., Aydin
Aydin,C.
Aydın,C.
Canset, Aydin
Aydin, Canset
Aydin C.
Aydın, Canset
A., Canset
C.,Aydın
Aydin,C.C.
Job Title
Doktor Öğretim Üyesi
Email Address
canset.aydin@atilim.edu.tr
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Surgical Sciences
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57222426930
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WoS Researcher ID
DSK-1333-2022

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IEEE International Symposium on Personal, Indoor and Mobile Radio Communications, PIMRC -- 18th Annual IEEE International Symposium on Personal, Indoor and Mobile Radio Communications, PIMRC'07 -- 3 September 2007 through 7 September 2007 -- Athens -- 721052
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American Journal of Otolaryngology1
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Start date: 2021Subject: 2-Arachidonoylglycerol

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    Article
    Citation - WoS: 9
    Citation - Scopus: 11
    Human Laryngeal Squamous Cell Carcinoma Cell Line Release of Endogenous Anandamide and 2-Arachidonoylglycerol, and Their Antiproliferative Effect Via Exogenous Supplementation: an in Vitro Study
    (Springer, 2022) Onay, Ovsen; Kose, Sevil; Suslu, Nilda; Korkusuz, Petek; Nemutlu, Emirhan; Aydin, Canset; Hosal, Sefik
    The level of the major endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG) are altered in several types of carcinomas, and are known to regulate tumor growth. Thusly, this study hypothesized that the HEp-2 human laryngeal squamous cell carcinoma (LSCC) cell line releases AEA and 2-AG, and aimed to determine if their exogenous supplementation has an anti-proliferative effect in vitro. In this in vitro observational study a commercial human LSCC cell line (HEp-2) was used to test for endogenous AEA and 2-AG release via liquid chromatography-tandem mass spectrometry (LC-MS/MS). The anti-proliferative effect of AEA and 2-AG supplementation was evaluated via WST-1 proliferation assay. It was observed that the HEp-2 LSCC cell line released AEA and 2-AG; the median quantity of AEA released was 15.69 ng mL(-1) (range: 14.55-15.95 ng mL(-1)) and the median quantity of 2-AG released was 2.72 ng (-1) (range: 2.67-2.74 ng mL(-1)). Additionally, both AEA and 2-AG exhibited an anti-proliferative effect. The anti-proliferative effect of 2-AG was stronger than that of AEA. These findings suggest that AEA might function via a CB1 receptor-independent pathway and that 2-AG might function via a CB2-dependent pathway. The present findings show that the HEp-2 LSCC cell line releases the major endocannabinoids AEA and 2-AG, and that their supplementation inhibits tumor cell proliferation in vitro. Thus, cannabinoid ligands might represent novel drug candidates for laryngeal cancers, although functional in vivo studies are required in order to validate their potency.