Sarıçam, Ersin

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https://hdl.handle.net/20.500.14411/7015
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Ersin, Saricam
Saricam E.
S.,Ersin
Saricam, Ersin
Sariçam E.
E.,Sarıçam
Ersin, Sariçam
S., Ersin
E., Saricam
Sarıçam, Ersin
Ersin, Sarıçam
E.,Saricam
E., Sarıçam
Sarıçam,E.
E.,Sariçam
E., Sariçam
Sariçam, Ersin
Saricam,E.
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Doçent Doktor
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ersin.saricam@atilim.edu.tr
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Internal Medical Sciences
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15840456000
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JKB-8115-2023

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    Article
    Comparison of Amiodarone Loading Dosage in the Treatment of Postoperative Atrial Fibrillation: High Versus Standard Dose Treatment
    (Bentham Science Publ Ltd, 2024) Sarıçam, E.; Öcal, A.; Iscanlı, M.D.; Bozkurt, E.; Ilkay, E.; Cantekin, ÖF.
    BACKGROUND: Postoperative atrial fibrillation (POAF) is associated with poor outcomes, including hemodynamic instability, stroke, myocardial infarction, and death. In hemodynamic stable patients, the rhythm-control strategy is more advantageous than rate control. Current standard intravenous amiodarone administration has limited success and a delayed effect; the acute success rate is 44% (8-12 h to several days). PURPOSE: The aim of this study was to evaluate the effectiveness of higher amiodarone loading dosage to restore sinus rhythm in patients with POAF after noncardiac surgery. METHODS: This is a prospective, randomized, controlled single-center study. The study included 39 patients with POAF, divided into group I (n=27) (intravenous 600 mg amiodarone loading dosage over 2 h and infusion of 50 mg/h over a 24-h period) and group II (n=12) (standard protocol; 300 mg of bolus intravenously in 30 min and infusion of 50 mg/h over a 24-h period). The primary endpoint of the study was a restoration of sinus rhythm at the 24th hour. RESULTS: Baseline clinical, laboratory and echocardiographic characteristics of both groups were similar. The patients with higher loading amiodarone dosage had earlier restoration of sinus rhythm (2.38 ± 1.41 vs 8.66 ± 2.87 h, respectively; p=0.015). There was no significant difference in achieving sinus rhythm at the 24th hour between both groups. CONCLUSION: Higher loading amiodarone dosage increased early conversions to sinus rhythm compared with standard amiodarone protocol in patients with POAF. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.