Tülek, Necla

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https://hdl.handle.net/20.500.14411/6675
Name Variants
Tülek,N.
N.,Tulek
Tülek, Necla
Eren Tülek N.
T., Necla
Tulek,Necla
Necla, Tulek
Necla, Tülek
N., Tülek
Necla Tülek
Tulek,N.
Tulek, Necla
Tulek N.
T.,Necla
N., Tulek
Tülek N.
N.,Tülek
Job Title
Profesör Doktor
Email Address
necla.tulek@atilim.edu.tr
Main Affiliation
Basic Sciences
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Website
www.neclaerentulek.com
ORCID ID
0000-0002-3952-4982
Scopus Author ID
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID
M-3283-2017

Sustainable Development Goals

NO POVERTY1
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ZERO HUNGER2
ZERO HUNGER
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GOOD HEALTH AND WELL-BEING3
GOOD HEALTH AND WELL-BEING
13
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QUALITY EDUCATION4
QUALITY EDUCATION
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GENDER EQUALITY5
GENDER EQUALITY
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CLEAN WATER AND SANITATION6
CLEAN WATER AND SANITATION
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AFFORDABLE AND CLEAN ENERGY7
AFFORDABLE AND CLEAN ENERGY
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DECENT WORK AND ECONOMIC GROWTH8
DECENT WORK AND ECONOMIC GROWTH
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INDUSTRY, INNOVATION AND INFRASTRUCTURE9
INDUSTRY, INNOVATION AND INFRASTRUCTURE
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REDUCED INEQUALITIES10
REDUCED INEQUALITIES
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SUSTAINABLE CITIES AND COMMUNITIES11
SUSTAINABLE CITIES AND COMMUNITIES
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RESPONSIBLE CONSUMPTION AND PRODUCTION12
RESPONSIBLE CONSUMPTION AND PRODUCTION
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CLIMATE ACTION13
CLIMATE ACTION
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LIFE BELOW WATER14
LIFE BELOW WATER
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LIFE ON LAND15
LIFE ON LAND
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PEACE, JUSTICE AND STRONG INSTITUTIONS16
PEACE, JUSTICE AND STRONG INSTITUTIONS
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PARTNERSHIPS FOR THE GOALS17
PARTNERSHIPS FOR THE GOALS
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This researcher does not have a Scopus ID.
Documents

125

Citations

1713

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Scholarly Output

17

Articles

12

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26/11

Supervised MSc Theses

0

Supervised PhD Theses

0

WoS Citation Count

19

Scopus Citation Count

19

Patents

0

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0

WoS Citations per Publication

1.12

Scopus Citations per Publication

1.12

Open Access Source

13

Supervised Theses

0

JournalCount
Indian Pediatrics3
Flora the Journal of Infectious Diseases and Clinical Microbiology2
Clinical Microbiology and Infection1
Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi1
Infectious Diseases and Clinical Microbiology1
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End date: 2026

Scholarly Output Search Results

Now showing 1 - 10 of 17
  • Thumbnail Image
    Editorial
    Photo Quiz; Anthrax or Orf?
    (Doc design informatics Co Ltd, 2019) Tulek, Necla; Kilic, Esra Kaya; Ertem, GunayTuncer; Yuksekkaya, Esra
    [No Abstract Available]
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    Article
    Citation - WoS: 1
    Retrospective Evaluation of Potential Rabies Exposure Cases Over Nine Years: Single-Center Experience
    (Bilimsel Tip Yayinevi, 2024) Demircan, Serife Altun; Kilic, Esra Kaya; Tulek, Necla; Kinikli, Sami; Bulut, Cemal
    Introduction: T & uuml;rkiye is the only European country where suspected rabies exposure from animal contact is a significant public health concern. In this study, we evaluate cases investigated in our vaccination center, where individuals with suspected rabies exposure have been seeking consultation for many years. The evaluation encompasses demographic characteristics, distribution by years and seasons, the type of animal involved in the contact, the prevalence of stray animals, and the rabies vaccination status of owned animals. Materials and Methods: The study involves cases reported to the Public Health Center from those who sought consultation at our center between January 1, 2011, and December 31, 2019. Demographic characteristics, distribution by years and seasons, the type of animal involved in the contact, the prevalence of stray animals, and the rabies vaccination status of owned animals were retrospectively evaluated. Results: Over the nine years, there were a total of 39.731 cases, resulting in an average of 4414 cases per year. Of these cases, 61% were male, and 68.83% were between the ages of 15 and 64. The most cases occurred in summer and autumn. Of the suspected rabies contacts, 69% involved dogs, and 83.4% of these dogs were unowned. Forty-one point eight percent of the owned dogs were vaccinated. Eighty-nine point six percent of the cats were unowned, and the rate of vaccination among the owned cats was 28.2%. Over the years, there has been a decrease in the use of the 10 -day observation approach, while an increase in the administration of rabies vaccine and/or immunoglobulin has been observed. Conclusion: Seventy percent of all risky rabies contacts involve dogs, with a high rate of 84% of these dogs being unowned. To mitigate contact involving the risk of rabies, addressing the uncontrolled reproduction of stray animals, particularly dogs, and ensuring control and vaccination of the existing animal population appear to be primary measures. Improving the vaccination rate of owned animals, currently at only 30-40%, can prevent people from encountering risky rabies contacts, thereby potentially reducing the need for rabies prophylaxis significantly.
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    Article
    Investigation of Tetanus Seropositivity Levels in Adult Patients with Rabies Risk Exposure Admitted To a Hospital in Ankara
    (J Infection Developing Countries, 2025) Gurkaynak, Pinar; Demircan, Serife A.; Tulek, Necla; Kinikli, Sami; Erdinc, Fatma S.; Tuncer, Gunay
    Introduction: This study aimed to assess tetanus seropositivity levels among adult patients admitted to a tertiary care hospital following rabies risk exposure, and to explore potential factors influencing their immunological status. Methodology: This cross-sectional descriptive epidemiological study included 182 adult individuals (68 females and 114 males) who presented to the hospital following rabies risk exposure. The demographic data was collected during a face-to-face interview, and the tetanus antibody concentrations were assessed using a micro-enzyme-linked immunosorbent assay (ELISA) kit. Serum antibody levels of >= 0.1 IU/mL were defined as "seropositive", while values below this threshold were considered "seronegative". Results: Seropositivity was identified in 81.9% of the patients. There was a significant decline in antibody levels with age (p < 0.001). The Spearman correlation analysis showed a moderately significant negative correlation between age and antibody titers (r = - 0.404, p < 0.001). In addition, there were significantly higher tetanus antibody levels in patients from urban areas, those vaccinated during pregnancy, and those vaccinated within the past 10 years (p = 0.025, 0.036, and 0.013, respectively). Conclusions: Overall, the results highlight a reduction in tetanus antibody levels with age, emphasizing the importance of receiving a booster dose every 10 years. In addition, rabies risk exposure, particularly in older adults, presents a valuable opportunity to administer tetanus vaccination.
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    Review
    Citation - WoS: 3
    Citation - Scopus: 4
    Akciğer Kanserinde İmmünoterapi ve Tedavide Multidisipliner Yaklaşım
    (Turkish Assoc Tuberculosis & Thorax, 2020) Karadurmuş, Nuri; Kaya, Akın; Göksel, Tuncay; Yılmaz, Ülkü; Tülek, Necla
    Akciğer kanseri dünya genelinde kanserle ilişkili ölümlerin başlıca nedeniolmaya devam etmektedir. Son 20 yılda kanser biyolojisi ve patogenezi hakkındaki bilgiler artmış, immün kontrol noktası inhibitörleri (İKNİ) kullanımasunulmuş ve böylece solid kanserlerin tedavisinde önemli bir dönem başlamıştır. Bu derlemede; tedavide yenilikler, immünoterapi ve tedavide multidisipliner yaklaşım çerçevesinde akciğer kanseri ele alınmıştır. Küçük hücreli dışıakciğer kanseri (KHDAK) en sık görülen ve özellikleri nedeniyle İKNİ tedavisinden ideal olarak yararlanabilecek akciğer kanseri türü olması nedeniyleyazının odak noktasını oluşturmuştur. Bu derleme, akciğer kanseri tedavisindeimmünoterapi yaklaşımının göğüs hastalıkları başta olmak üzere tüm branşlarda multidisipliner farkındalığını artırmayı ve yönetimi hakkında bilgi sağlamayıamaçlayan ilk Türkçe derlemedir. Ayrıca bu derleme, KHDAK tedavisinde İKNİkullanımına ilişkin son klinik çalışmaların dikkat çekici sonuçlarını sunmasıaçısından önem teşkil etmektedir. İmmünoterapi kanser tedavisinde yeni bir dönem başlatmıştır ve İKNİ tedavisinin kendine özgü etki mekanizması yeni bazı advers olay grubunun ortaya çıkmasına nedenolmuştur, bunlar arasında pnömonitis özellikle önemlidir ve advers olaylar konusunda gerektiğinde hastaların ilgili uzmanlık dalları ilekonsülte edilmesi gerekmektedir. Akciğer kanserinde tedavi, hastanın özellikleri, histolojik özellikler, genetik durum göz önünde bulundurularak her bir hastaya özel planlanmalı ve akciğer kanserli bir hastanın tanısal değerlendirilmesi ve en uygun şekilde tedavisi içingöğüs hastalıkları, göğüs cerrahisi, tıbbi onkoloji, radyasyon onkolojisi, patoloji ve radyoloji uzmanlık dalları arasında işbirliği sağlanmalıdır. Bununla birlikte, aile hekimleri de akciğer kanserinin erken tanınmasında ve ayrıca hastalarını tütün bırakmayı teşvik ederekkanserin önlenmesinde önemli rol oynayabilirler. Ayrıca, toplumda farkındalık yaratmak ve erken tanı için akciğer kanseri yönündentarama çalışmaları yapmak hedeflenmelidir
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    Article
    The Effect Of Constructivist Training On The Rate Of Catheter-Associated Urinary Tract Infections in The Intensive Care Unit
    (Anestezi Dergisi, 2025) Yarimoglu, Saliha; Erdinç, Fatma Şebnem; Kaymak, Çetin; Tulek, Eren, N.; Basa̧r, Hulya; Tuncer-Ertem, Günay,; Kinikli, Sami; Tulek, Necla; Ertem, Gunay Tuncer
    Objective: Catheter-associated urinary tract infections (CA-UTIs) are common healthcare-associated infections. Constructivist training is based on integrating new knowledge with previously learned knowledge. The aim of this study was to evaluate the effects of constructivist training on the rate of CA-UTIs in the Anesthesia and Reanimation Intensive Care Units (ARICU). Methods: This study was a retrospective-prospective intervention study. Over the period of one month, a total of 62 healthcare staff (seven doctors, 38 nurses, and 17 cleaning staff) working in ARICUs were organized into groups of 4-5 people and received forty-five minutes of constructivist training on preventing CA-UTI. Personnel from each of three ICUs participated in the same number of training sessions. Comparisons were made of the rates of CA-UTI and catheter use in the six-month periods before and after the training. A 4-item questionnaire was administered to the study participants six months after completion of the training. Results: The catheter-associated urinary tract infection rates before and after training were observed to be 8.3 and 8.7 per 1000 catheter days, respectively in ARICU-1, 7.0 and 8.1 per 1000 catheter days in ARICU-2, and 7.3 and 9.9 per 1000 catheter days in ARICU-3. No statistically significant difference was observed in the CA-UTI rate in each unit after constructivist training compared to the pre-training period. The intervention of constructivist training alone did not reduce the CA-UTI rates in the ICUs. According to the results of the survey conducted six months later, 92% of the nurses and 88% of the cleaning staff stated that constructivist training had positive effects. Conclusion: The intervention of constructivisit training alone did not reduce the rates of CA-UTIs in the ARICUs, but an increase was observed in the awareness of ICU nurses and cleaning staff. © 2025 Elsevier B.V., All rights reserved.
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    Review
    Hepatit B İnfeksiyonlarının İmmünopatogenezi
    (Bilimsel Tip Yayinevi, 2019) Tülek, Necla
    Hepatit B infeksiyonları tüm dünyada majör sağlık problemleri arasında olup, siroz ve hepatoselüler karsinomanın en önemli nedenidir.Tedavide gelişmelere rağmen henüz kronik hepatit B infeksiyonunda kür sağlanamamaktadır. Hepatit B infeksiyonlarında klinik sonuçinfeksiyonun alınma yaşı, viral yük ve konağın immün yanıtına bağlıdır. Akut hepatitlerde klinik seyir subklinik hastalıktan, anikterikhepatite, ikterik hepatite ve fulminant hepatite kadar değişebilirken, kronik hepatitlerde hastalığın seyri asemptomatik inaktif durumdankronik hepatite, siroz ve hepatoselüler karsinomaya kadar değişebilir. Hepatit B virüsü hepatositlerde sitopatik olmayarak çoğalır veklinik sendromların çoğu immün yanıt ile ilişkilidir. İmmün sistem aktivasyonu virüsün eliminasyonunu sağladığı gibi karaciğer hasarınada neden olur. Hepatit B patogenezinde hücresel immün yanıt özellikle de CD8+ T hücreler santral olmasına rağmen immün sistemindiğer komponentleri de katkıda bulunur. Kronik hepatitli hastalarda hem doğal hem de adaptif immün yanıt zayıflamış ve T hücreyanıtı tükenmiş durumdadır. İmmünopatolojideki mekanizmaların daha iyi anlaşılması, yeni etkin tedavi stratejilerinin geliştirilmesindeyararlı olacaktır.
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    Article
    Tedavi Alan Kronik Hepatit B Hastalarında Serum Kantitatif Hbsag Düzeyi ile Viral Yük Arasındaki İlişkinin Araştırılması
    (Pamukkale University, 2020) Demirelli, Meryem; Tülek, Necla; Temoçin, Fatih; Yücel, Doğan; Erdinç, Fatma Şebnem; Ertem, Günay; Erdinc, Sebnem
    Amaç: Yakın geçmişe kadar HBsAg sadece hepatit B enfeksiyonun tanısında kullanılırken, günümüzde serum HBsAg kantitasyonu (qHBsAg)’nun, hepatit B virüsü (HBV) enfeksiyonunun viral monitörizasyonunda kullanılabileceğine dair veriler artmaya başlamıştır. Bu çalışmada inaktif hepatit B taşıyıcıları ile kronik aktif hepatit B hastaları arasındaki qHBsAg ile HBV DNA düzeyleri karşılaştırılmış ve tedavi başlanmış hastalarda tedavi süresince qHBsAg ile HBVDNA seyri izlenerek aralarındaki ilişki değerlendirilmiştir. Gereç ve yöntem: Çalışma Ankara Eğitim ve Araştırma Hastanesi Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği’nde yapılmıştır. Kronik hepatit B (KHB) tanısıyla tedavi alan 71 hasta ve inaktif HBsAg taşıyıcısı 74 hasta çalışmaya dahil edildi. Bu hastalarda serum qHBsAg düzeyleri Elecsys HBsAg II cihazı ile çalışıldı. Bulgular: Nükleoz(t)id analoğu ile tedavi edilen hastalarda 6. ve 12. aydaki serum qHBsAg düzeyi ile HBVDNA arasında pozitif yönde bir korelasyon görüldü ve her iki parametrenin altı ay ve bir yıllık izlemindeki düşüş istatiksel olarak anlamlı bulundu (qHBsAg 6ay p=0,03, qHBsAg 12 ay p=0,001, HBV DNA 6 ay p=0,001, HBV DNA 12 ay p=0,001). Peg-IFN tedavisi alan kronik hepatit B hastalarında ise serum qHBsAg düzeyi ile HBVDNA arasında tedavi başlangıcı ve 6. ayında anlamlı bir ilişki olmayıp tedavi sonunda pozitif yönde korelasyon görüldü. PEG-IFN tedavisi alan hasta grubunda ise qHBsAg seviyeleri ile HBV DNA arasındaki korelasyon tedavi sonunda anlamlı (p=0,01) olarak saptandı.
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    Article
    Citation - Scopus: 1
    Impact of the COVID-19 Pandemic on Diabetic Foot Patients A Shift in the Infectious Agent Profile Toward Nonfermentative
    (Amer Podiatric Med Assoc, 2024) Acar, Ali; Saltoglu, Nese; Tulek, Necla; Turha, Ozge; Nazliserin, Elif; Yapar, Derya; Kaya, Sibel Dogan; Turhan, Özge; Serin, Elif Nazlı; Saltoğglu, Nesşe
    Background: Diabetes foot infection is a very important public health problem that causes serious health problems, mortality, and high health expenditures, and is one of the most important complications of diabetes mellitus. There are concerns that approaches such as limited personal visits to doctors, avoidance of hospitals, and restrictions on nonemergency surgical procedures during the coronavirus disease of 2019 pandemic pose a threat to those with diabetic foot problems, including diabetic foot ulcers (DFUs), ischemia, and infection, resulting in increased limb loss and mortality. Methods: This multicenter, retrospective, cross-sectional study was conducted in 14 tertiary care hospitals from various regions of Turkey. A total of 1,394 patient records were evaluated, 794 of which were between January 1, 2019, and January 30, 2020 (prepandemic [Pre-P]), and 605 of which were between February 1, 2020, and February 28, 2021 (pandemic period [PP]). Results: During the PP, diabetic foot patient follow-up decreased by 23.8%. In addition, the number of hospitalizations attributable to DFU has decreased significantly during the PP (P = .035). There was no difference between the groups regarding patient demographics, medical history, DFU severity, biochemical and radiologic findings, or comorbidities, but the mean duration of diabetes mellitus years was longer in patients in the Pre-P than in those in the PP (15.1 years versus 13.7 years). There was no difference between the two groups in terms of major complications such as limb loss and mortality, but infection recurrence was higher in the PP than in the Pre-P (12.9% versus 11.4%; P < .05). The prevalence of nonfermentative gram-negative bacteria as causative agents in DFU infections increased during the PP. In particular, the prevalence of carbapenem-resistant Pseudomonas spp. increased statistically during the PP. Conclusions: The rapid adaptation to the pandemic with the measures and changes developed by the multidisciplinary diabetic foot care committees may be the reasons why there was no increase in complications because of DFU during the pandemic in Turkey.
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    Letter
    Medical Education During the Covid-19 Pandemic: Experience From a Newly Established Medical School
    (Springer, 2020) Tulek,N.; Gonullu,U.
    [No abstract available]
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    Article
    Citation - WoS: 11
    Citation - Scopus: 11
    Impact of Vaccination on the Presence and Severity of Symptoms in Hospitalized Patients With an Infection of the Omicron Variant (b.1.1.529) of the Sars-Cov (subvariant Ba.1)
    (Elsevier Sci Ltd, 2023) Beraud, Guillaume; Bouetard, Laura; Civljak, Rok; Michon, Jocelyn; Tulek, Necla; Lejeune, Sophie; Epaulard, Olivier
    Objectives: The emergence of SARS-CoV-2 variants raised questions about the extent to which vaccines designed in 2020 have remained effective. We aimed to assess whether vaccine status was associated with the severity of Omicron SARS-CoV-2 infection in hospitalized patients.Methods: We conducted an international, multi-centric, retrospective study in 14 centres (Bulgaria, Croatia, France, and Turkey). We collected data on patients hospitalized for >= 24 hours between 1 December 2021 and 3 March 2022 with PCR-confirmed infection at a time of exclusive Omicron circu-lation and hospitalization related or not related to the infection. Patients who had received prophylaxis by monoclonal antibodies were excluded. Patients were considered fully vaccinated if they had received at least two injections of either mRNA and/or ChAdOx1-S or one injection of Ad26.CoV2-S vaccines. Results: Among 1215 patients (median age, 73.0 years; interquartile range, 57.0-84.0; 51.3% men), 746 (61.4%) were fully vaccinated. In multivariate analysis, being vaccinated was associated with lower 28 -day mortality (Odds Ratio [95% Confidence Interval] (OR [95CI]) = 0.50 [0.32-0.77]), intensive care unit admission (OR [95CI] = 0.40 [0.26-0.62]), and oxygen requirement (OR [95CI] = 0.34 [0.25-0.46]), independent of age and comorbidities. When co-analysing these patients with Omicron infection with 948 patients with Delta infection from a study we recently conducted, Omicron infection was associated with lower 28-day mortality (OR [95CI] = 0.53 [0.37-0.76]), intensive care unit admission (OR [95CI] = 0.19 [0.12-0.28]), and oxygen requirements (OR [95CI] = 0.50 [0.38-0.67]), independent of age, comorbidities, and vaccination status.Discussion: Originally designed vaccines have remained effective on the severity of Omicron SARS-CoV-2 infection. Omicron is associated with a lower risk of severe forms, independent of vaccination and pa-tient characteristics. Guillaume Beraud, Clin Microbiol Infect 2023;29:642 (c) 2022 The Author(s). Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).