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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14411/22

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Citation - WoS: 23
Citation - Scopus: 22
3d Bioprinting Tissue Analogs: Current Development and Translational Implications
(Sage Publications inc, 2023) Liu, Suihong; Cheng, Lijia; Liu, Yakui; Zhang, Haiguang; Song, Yongteng; Park, Jeong-Hui; Ramalingam, Murugan; 01. Atılım University
Three-dimensional (3D) bioprinting is a promising and rapidly evolving technology in the field of additive manufacturing. It enables the fabrication of living cellular constructs with complex architectures that are suitable for various biomedical applications, such as tissue engineering, disease modeling, drug screening, and precision regenerative medicine. The ultimate goal of bioprinting is to produce stable, anatomically-shaped, human-scale functional organs or tissue substitutes that can be implanted. Although various bioprinting techniques have emerged to develop customized tissue-engineering substitutes over the past decade, several challenges remain in fabricating volumetric tissue constructs with complex shapes and sizes and translating the printed products into clinical practice. Thus, it is crucial to develop a successful strategy for translating research outputs into clinical practice to address the current organ and tissue crises and improve patients' quality of life. This review article discusses the challenges of the existing bioprinting processes in preparing clinically relevant tissue substitutes. It further reviews various strategies and technical feasibility to overcome the challenges that limit the fabrication of volumetric biological constructs and their translational implications. Additionally, the article highlights exciting technological advances in the 3D bioprinting of anatomically shaped tissue substitutes and suggests future research and development directions. This review aims to provide readers with insight into the state-of-the-art 3D bioprinting techniques as powerful tools in engineering functional tissues and organs.
Citation - WoS: 3
Citation - Scopus: 4
Akciğer Kanserinde İmmünoterapi ve Tedavide Multidisipliner Yaklaşım
(Turkish Assoc Tuberculosis & Thorax, 2020) Karadurmuş, Nuri; Kaya, Akın; Göksel, Tuncay; Yılmaz, Ülkü; Tülek, Necla; Basic Sciences; 08. Medical School; 01. Atılım University
Akciğer kanseri dünya genelinde kanserle ilişkili ölümlerin başlıca nedeniolmaya devam etmektedir. Son 20 yılda kanser biyolojisi ve patogenezi hakkındaki bilgiler artmış, immün kontrol noktası inhibitörleri (İKNİ) kullanımasunulmuş ve böylece solid kanserlerin tedavisinde önemli bir dönem başlamıştır. Bu derlemede; tedavide yenilikler, immünoterapi ve tedavide multidisipliner yaklaşım çerçevesinde akciğer kanseri ele alınmıştır. Küçük hücreli dışıakciğer kanseri (KHDAK) en sık görülen ve özellikleri nedeniyle İKNİ tedavisinden ideal olarak yararlanabilecek akciğer kanseri türü olması nedeniyleyazının odak noktasını oluşturmuştur. Bu derleme, akciğer kanseri tedavisindeimmünoterapi yaklaşımının göğüs hastalıkları başta olmak üzere tüm branşlarda multidisipliner farkındalığını artırmayı ve yönetimi hakkında bilgi sağlamayıamaçlayan ilk Türkçe derlemedir. Ayrıca bu derleme, KHDAK tedavisinde İKNİkullanımına ilişkin son klinik çalışmaların dikkat çekici sonuçlarını sunmasıaçısından önem teşkil etmektedir. İmmünoterapi kanser tedavisinde yeni bir dönem başlatmıştır ve İKNİ tedavisinin kendine özgü etki mekanizması yeni bazı advers olay grubunun ortaya çıkmasına nedenolmuştur, bunlar arasında pnömonitis özellikle önemlidir ve advers olaylar konusunda gerektiğinde hastaların ilgili uzmanlık dalları ilekonsülte edilmesi gerekmektedir. Akciğer kanserinde tedavi, hastanın özellikleri, histolojik özellikler, genetik durum göz önünde bulundurularak her bir hastaya özel planlanmalı ve akciğer kanserli bir hastanın tanısal değerlendirilmesi ve en uygun şekilde tedavisi içingöğüs hastalıkları, göğüs cerrahisi, tıbbi onkoloji, radyasyon onkolojisi, patoloji ve radyoloji uzmanlık dalları arasında işbirliği sağlanmalıdır. Bununla birlikte, aile hekimleri de akciğer kanserinin erken tanınmasında ve ayrıca hastalarını tütün bırakmayı teşvik ederekkanserin önlenmesinde önemli rol oynayabilirler. Ayrıca, toplumda farkındalık yaratmak ve erken tanı için akciğer kanseri yönündentarama çalışmaları yapmak hedeflenmelidir
Antioxidant Activity of Micractinium Sp. (Chlorophyta) Extracts Against H2o2 Induced Oxidative Stress in Human Breast Adenocarcinoma Cells
(Nature Portfolio, 2025) Bulut, Onur; Kose, Iskin Engin; Sonmez, Cagla; Oktem, Huseyin Avni; Basic Sciences; 08. Medical School; 01. Atılım University
Citation - WoS: 33
Citation - Scopus: 36
Aptamer Hybrid Nanocomplexes as Targeting Components for Antibiotic/Gene Delivery Systems and Diagnostics: a Review
(Dove Medical Press Ltd, 2020) Rabiee, Navid; Ahmadi, Sepideh; Arab, Zeynab; Bagherzadeh, Mojtaba; Safarkhani, Moein; Nasseri, Behzad; Tayebi, Lobat; 01. Atılım University
With the passage of time and more advanced societies, there is a greater emergence and incidence of disease and necessity for improved treatments. In this respect, nowadays, aptamers, with their better efficiency at diagnosing and treating diseases than antibodies, are at the center of attention. Here, in this review, we first investigate aptamer function in various fields (such as the detection and remedy of pathogens, modification of nanoparticles, antibiotic delivery and gene delivery). Then, we present aptamer-conjugated nanocomplexes as the main and efficient factor in gene delivery. Finally, we focus on the targeted co-delivery of genes and drugs by nanocomplexes, as a new exciting approach for cancer treatment in the decades ahead to meet our growing societal needs.
Citation - WoS: 16
Citation - Scopus: 20
Assessing the Coverage of E-Health Services in Sub-Saharan Africa a Systematic Review and Analysis
(Georg Thieme verlag Kg, 2017) Adeloye, Davies; Adigun, Taiwo; Misra, Sanjay; Omoregbe, Nicholas; Computer Engineering; 06. School Of Engineering; 01. Atılım University
Background: E-Health has attracted growing interests globally. The relative lack of facilities, skills, funds and information on existing e-Health initiatives has affected progress on e-Health in Africa. Objectives: To review publicly available literature on e-Health in sub-Saharan Africa (sSA) towards providing information on existing and ongoing e-Health initiatives in the region. Methods: Searches of relevant literature were conducted on Medline, EMBASE and Global Health, with search dates set from 1990 to 2016. We included studies on e-Health initiatives (prototypes, designs, or completed projects) targeting population groups in sSA. Results: Our search returned 2322 hits, with 26 studies retained. Included studies were conducted in 14 countries across the four sub-regions in sSA (Central, East, South and West) and spreading over a 12-year period, 2002-2014. Six types of e-Health interventions were reported, with 17 studies (65%) based on telemedicine, followed by mHealth with 5 studies (19%). Other e-Health types include expert system, electronic medical records, e-mails, and online health module. Specific medical specialties covered include dermatology (19%), pathology (12%) and radiology (8%). Successes were 'widely reported' (representing 50% overall acceptance or positive feedbacks in a study) in 10 studies (38%). The prominent challenges reported were technical problems, poor inter net and connectivity, participants' selection biases, contextual issues, and lack of funds. Conclusion: E-Health is evolving in sSA, but with poorly published evidence. While we call for more quality research in the region, it is also important that population-wide policies and on-going e-Health initiatives are contextually feasible, acceptable, and sustainable.
Citation - WoS: 58
Citation - Scopus: 68
Atmospheric Pressure Plasma Surface Treatment of Polymers and Influence on Cell Cultivation
(Mdpi, 2021) Sasmazel, Hilal Turkoglu; Alazzawi, Marwa; Alsahib, Nabeel Kadim Abid; Metallurgical and Materials Engineering; 06. School Of Engineering; 01. Atılım University
Atmospheric plasma treatment is an effective and economical surface treatment technique. The main advantage of this technique is that the bulk properties of the material remain unchanged while the surface properties and biocompatibility are enhanced. Polymers are used in many biomedical applications; such as implants, because of their variable bulk properties. On the other hand, their surface properties are inadequate which demands certain surface treatments including atmospheric pressure plasma treatment. In biomedical applications, surface treatment is important to promote good cell adhesion, proliferation, and growth. This article aim is to give an overview of different atmospheric pressure plasma treatments of polymer surface, and their influence on cell-material interaction with different cell lines.
Author`s Reply
(Turkish Society of Cardiology, 2020) Karaduman,B.D.; Ayhan,H.; Keleş,T.; Bozkurt,E.; 01. Atılım University
[No abstract available]
Author`s Reply
(NLM (Medline), 2021) Duran Karaduman,B.; Ayhan,H.; Keleş,T.; Bozkurt,E.; 01. Atılım University
[No abstract available]
Bilateral adrenal haemorrhage after blunt abdominal trauma
(Ma Healthcare Ltd, 2023) Guvendi, Bulent; Koksal, Ali; Gozgec, Elif; Ogul, Hayri; Kantarci, Mecit; Medical Imaging Techniques Program; 12. Department of Medical Services and Techniques; 01. Atılım University
[No Abstract Available]
Citation - WoS: 26
Citation - Scopus: 29
Bioprinting and biomaterials for dental alveolar tissue regeneration
(Frontiers Media Sa, 2023) Ostrovidov, Serge; Ramalingam, Murugan; Bae, Hojae; Orive, Gorka; Fujie, Toshinori; Shi, Xuetao; Kaji, Hirokazu; 01. Atılım University
Three dimensional (3D) bioprinting is a powerful tool, that was recently applied to tissue engineering. This technique allows the precise deposition of cells encapsulated in supportive bioinks to fabricate complex scaffolds, which are used to repair targeted tissues. Here, we review the recent developments in the application of 3D bioprinting to dental tissue engineering. These tissues, including teeth, periodontal ligament, alveolar bones, and dental pulp, present cell types and mechanical properties with great heterogeneity, which is challenging to reproduce in vitro. After highlighting the different bioprinting methods used in regenerative dentistry, we reviewed the great variety of bioink formulations and their effects on cells, which have been established to support the development of these tissues. We discussed the different advances achieved in the fabrication of each dental tissue to provide an overview of the current state of the methods. We conclude with the remaining challenges and future needs.
Citation - WoS: 1
Citation - Scopus: 1
Commentary on "spectral Characterization of the Binding and Conformational Changes of Serum Albumins Upon Interaction With an Anticancer Drug, Anastrozole"
(Pergamon-elsevier Science Ltd, 2015) Korkmaz, Filiz; Physics Group; 06. School Of Engineering; 01. Atılım University
The manuscript by R. Punith and J. Seetharamappa (http://dx.doi.org/10.1016/j.saa.201202.038) presents the interaction between serum albumin from human (HAS) and from bovine (BSA) with a drug called Anastrozole (AZ). The drug is on the market for treating patients with breast cancer after surgery and for metastasis in women. The study utilizes various spectroscopic techniques such as; fluorescence, synchronous fluorescence, 3D fluorescence measurements, FTIR, CD and UV. Although there are some relatively minor comments on the paper, the main point that needs to be reviewed by the authors is the result of FTIR measurements. Based on the data provided in the text (there is no figure), the protein sample is not in its native state, which makes the data inconvenient to be used in drawing conclusions. Authors are kindly requested to take another look at the FUR experiments. (C) 2014 Elsevier B.V. All rights reserved.
Citation - WoS: 23
Controlled Gene Delivery Systems: Nanomaterials and Chemical Approaches
(Amer Scientific Publishers, 2020) Ahmadi, Sepideh; Rabiee, Navid; Fatahi, Yousef; Bagherzadeh, Mojtaba; Gachpazan, Meysam; Baheiraei, Nafiseh; Hamblin, Michael R.; 01. Atılım University
Successful gene therapy depends on the design of effective gene delivery systems. A gene delivery system is considered a powerful tool for the release of genetic material within cells resulting in a change in cell functions and protein production. The release of genes in a controlled manner by using appropriate carriers facilitates their release without side effects and increases the expression of genes at the released site. It is expected that significant changes in the combination of several genes and drugs can be provided by developing treatment systems sensitive to different stimuli such as redox potential, pH variations, temperature gradients, light irradiation, and enzyme activity. The most important advantages for the release of genes and stimuli-responsive therapeutics include delivering vectors locally, reducing side effects and causing no toxicity to distant tissues while at the same time reducing the immune response to the vectors. In this review, we aim to discuss different types of gene carriers involved in the controlled transfer of nucleic acids (non-viral inorganic and organic nanoparticles (NPs) and virus-like particles (VLPs)) as well as the simultaneous transfer of several genes and/or drugs into cells or different tissues, providing for an efficient and safe treatment of numerous diseases.
Correction: Cardiac Hypertrophy Caused by Hyperthyroidism in Rats: The Role of ATF-6 and TRPC1channels (Ref.: Can. J. Phys. Pharm. 99(11): 1226–1233. https://doi.org/10.1139/cjpp-2021-0260)
(Canadian Science Publishing, 2024) Bektur, N.E.; Şahin, E.; Kacar, S.; Bağcı, R.; Karakaya, Ş.; Burukoglu-Donmez, D.; Şahintürk, V.; Basic Sciences; 08. Medical School; 01. Atılım University
Correction: Evaluating Anterior Segment Stability and Corneal Endothelium After Prolene Gonioscopy Assisted Transluminal Trabeculotomy (GATT) in Open-Angle Glaucoma
(Springer, 2025) Aribas, Yavuz Kemal; Aktas, Zeynep; Ertop, Mestan; Surgical Sciences; 08. Medical School; 01. Atılım University
Citation - WoS: 7
Citation - Scopus: 8
Current Surgical Techniques for the Management of Pediatric Glaucoma: a Literature Review
(Frontiers Media Sa, 2023) Aktas, Zeynep; Ikiz, Gokcen Deniz Gulpinar; Surgical Sciences; Surgical Sciences; 08. Medical School; 01. Atılım University
Pediatric glaucoma surgery is challenging due to its diverse and complex pathophysiology, altered anterior segment anatomy, greater potential for failure, and complications compared to adult patients. Moreover, numerous challenges are associated with long-term postoperative management. Thus, when dealing with childhood glaucoma, it is important to consider the potential complications in addition to the benefits of each intervention. The purpose of this article is to review recently published literature to shed light on the most recent surgical techniques for the safe and effective treatment of childhood glaucoma. Current literature shows that goniotomy and trabeculotomy are the first choices for the management of primary congenital glaucoma. Although older children with phakic eyes seem to benefit from trabeculectomy with adjunctive mitomycin C, it carries a long-term risk of bleb-related endophthalmitis. Glaucoma drainage devices may be preferred for patients with secondary or refractory glaucoma. However, hypotony or tube-related complications are common and encountered more often in children than in adults. Cyclodestructive procedures are also an option for cases in which filtering surgery has failed, but they can also be used as a temporizing measure to reduce the rate of complications in high-risk patients. However, their outcomes can be unpredictable, in terms of efficiency and complications. Finally, minimally invasive glaucoma surgery (MIGS) as the sole alternative treatment or as an adjunctive surgical procedure is a relatively new path for pediatric patients.
Citation - WoS: 1
The Day the Earth Shook
(Springer Heidelberg, 2023) Sezer, Siren; Tuglular, Serhan; Yildiz, Alaattin; 01. Atılım University
[No Abstract Available]
Diagnostic Use of Circulating Cells and Sub-Cellular Bio-Particles
(Pergamon-elsevier Science Ltd, 2024) Tevlek, Atakan; Basic Sciences; 08. Medical School; 01. Atılım University
In the bloodstream or other physiological fluids, "circulating cells and sub-cellular bio-particles" include many microscopic biological elements such as circulating tumor cells (CTCs), cell-free DNA (cfDNA), exosomes, microRNAs, platelets, immune cells, and proteins are the most well-known and investigated. These structures are crucial biomarkers in healthcare and medical research for the early detection of cancer and other disorders, enabling treatment to commence before the onset of clinical symptoms and enhancing the efficacy of treatments. As the size of these biomarkers to be detected decreases and their numbers in body fluids diminishes, the detection materials, ranging from visual inspection to advanced microscopy techniques, begin to become smaller, more sensitive, faster, and more effective, thanks to developing nanotechnology. This review first defines the circulating cells and subcellular bio-particles with their biological, physical, and mechanical properties and second focuses on their diagnostic importance, including their most recent applications as biomarkers, the biosensors that are utilized to detect them, the present obstacles that must be surmounted, and prospective developments in the domain. As technology advances and biomolecular pathways are deepens, diagnostic tests will become more sensitive, specific, and thorough. Finally, integrating recent advances in the diagnostic use of circulating cells and bioparticles into clinical practice is promising for precision medicine and patient outcomes.
Citation - WoS: 1
Citation - Scopus: 1
Economic Growth and Health Expenditures Relationship Between Oecd Countries
(Frontiers Media Sa, 2023) Tengilimoglu, Dilaver; Business; 05. School of Business; 01. Atılım University
[No Abstract Available]
Editorial: Biofabricated Materials for Tissue Engineering
(Frontiers Media Sa, 2024) Sasmazel, Hilal Turkoglu; Gunduz, Oguzhan; Ramalingam, Murugan; Ulag, Songul; Metallurgical and Materials Engineering; 06. School Of Engineering; 01. Atılım University
[No Abstract Available]
Editorial: Cells, Biomaterials, and Biophysical Stimuli for Bone, Cartilage, and Muscle Regeneration
(Frontiers Media Sa, 2023) Fassina, Lorenzo; Bloise, Nora; Ramalingam, Murugan; Cusella De Angelis, Maria Gabriella; Visai, Livia; 01. Atılım University
[No Abstract Available]

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