Pubmed

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14411/22

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Browsing Pubmed by Journal "Advances in Experimental Medicine and Biology"

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    Citation - Scopus: 6
    Cannabinoids as Prospective Anti-Cancer Drugs: Mechanism of Action in Healthy and Cancer Cells
    (Springer, 2023) Boyacıoğlu,Ö.; Korkusuz,P.; Basic Sciences; 08. Medical School; 01. Atılım University
    Endogenous and exogenous cannabinoids modulate many physiological and pathological processes by binding classical cannabinoid receptors 1 (CB1) or 2 (CB2) or non-cannabinoid receptors. Cannabinoids are known to exert antiproliferative, apoptotic, anti-migratory and anti-invasive effect on cancer cells by inducing or inhibiting various signaling cascades. In this chapter, we specifically emphasize the latest research works about the alterations in endocannabinoid system (ECS) components in malignancies and cancer cell proliferation, migration, invasion, angiogenesis, autophagy, and death by cannabinoid administration, emphasizing their mechanism of action, and give a future perspective for clinical use. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.
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    Erratum
    Erratum: Correction to: Stem Cell and Advanced Nano Bioceramic Interactions (Advances in Experimental Medicine and Biology (2018) 1077 Doi: 10.1007/978-981-13-0947-2_17.)
    (2018) Köse, S.; Kankilic, B.; Gizer, M.; Ciftci Dede, E.; Bayramli, E.; Korkusuz, P.; Korkusuz, F.; 01. Atılım University
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    A Niche-Based Perspective to Stem and Cancer Stem Cells of the Lung
    (Springer, 2025) Boyacıoğlu, Özge; Kalali, Berfin Deniz; Tongün, Ege; Korkusuz, Petek; Basic Sciences; 08. Medical School; 01. Atılım University
    Lungs carry the principle function for the conduction and exchange of air through the primary, secondary, tertiary bronchi, bronchioles, and alveoli, resulting in the exchange of oxygen to carbon dioxide within the human tissues. Lung stem and progenitor cells enable differentiation of parenchymal and stromal elements and provide homeostasis and regeneration in the microenvironment against pulmonary diseases. Tumor-initiating cancer cells (TICs) refer to a subpopulation named as cancer stem cells (CSCs) of lung cancer exhibiting high self-renewal and proliferation capacity by Notch, Hippo, Hedgehog, and Wnt signaling pathways that leads to tumor development or recurrence. Lung cancer stem cells (LCSCs) are characterized by distinct genotypic or phenotypic alterations compared to healthy lung stem cells (LSCs) that provide a potential target to treat lung cancer. Therefore, understanding the cascades responsible for the transformation of healthy to CSCs is essential to develop new targeted therapy approaches. In this chapter, we precisely highlight the latest researches on LSCs and CSCs, key signaling mechanisms within the perspective of novel targeted therapy strategies. © 2025 Elsevier B.V., All rights reserved.