Browsing by Author "Machin, Nesrin E."
Now showing 1 - 2 of 2
- Results Per Page
- Sort Options
Article Citation Count: 56Nanosized CaP-silk fibroin-PCL-PEG-PCL/PCL based bilayer membranes for guided bone regeneration(Elsevier Science Bv, 2017) Machın, Nesrin Ekinci; Pazarceviren, A. Engin; Keskin, Dilek; Machin, Nesrin E.; Duygulu, Ozgur; Tezcaner, Aysen; Chemical EngineeringGuided bone regeneration (GBR) concept has been developed to prevent the formation of non-functional scar tissue layer on defect site by undertaking barrier role. In this study, a new bilayer membrane which consisted of one layer of electrospun silk fibroin/PCL-PEG-PCL incorporating nanocalcium phosphate (SPCA)(1) and one layer of PCL membrane was developed for GBR. To improve the osteoconductivity of membranes, nanosized calcium phosphate particles synthesized by Flame Spray Pyrolysis method were incorporated into membranes at 10% (wt) (SPCA10) and 20% (wt) (SPCA20) of the polymer content. The structural and chemical analyses revealed the well-integrated two layers of membranes with a total thickness of ca 100 mu m. In the regenerative layer, the highly porous mesh structure had a thickness of 12.6 mu m with randomly oriented fibers having diameters around 760 nm, and nanoparticles dispersed homogenously. The mechanical test results showed remarkable improvement on the tensile strength of membranes with incorporation of nanoparticles. Higher water affinity of nanoCaP included membranes was proved by lower contact angle values and higher percent water uptake capacity. Biomineralization assay revealed that nucleation and growth of apatites around fibers of SPCA10 and SPCA20 were apparent while on SPCAO apatite minerals were barely detected after 10 days. Human dental pulp stem cells (DPSC) were seeded on electrospun layer of the bilayer membranes for biocompatibility and osteo-compatibility study. Increasing narioCaP amount resulted in higher cell adhesion, proliferation, ALP activity and calcium deposition on membranes. These overall results confirmed the biocompatibility and potential applicability of proposed membranes for GBR treatments. (C) 2017 Elsevier B.V. All rights reserved.Article Citation Count: 3A simple method to set the spray properties for flame spray pyrolysis production of nanoparticles(Elsevier Sci Ltd, 2020) Machın, Nesrin Ekinci; Machin, Nesrin E.; Chemical EngineeringThe most critical part of the flame spray pyrolysis (FSP) process is the nozzle, since it plays a key role in setting the spray properties. In this study, we developed an approach to adjust the nozzle throat gap size for a desired dispersion gas flow rate and upstream pressure, based on the external size and shape of a two phase external mixing nozzle. An equation was derived and validated by comparing the predicted gas flow rates with the data provided in a commercial nozzle supplier chart. Experiments were also conducted in our lab-scale FSP reactor to test the validity of the predictions. The approach developed here was found to closely predict the gap size necessary to pass the required dispersion gas flow at a desired pressure drop. Error in predictions was found to be less than 3% at an upstream pressure range of 3-10 bars. The isentropic flow assumption for perfect gases across the convergent-divergent nozzle was found to fail below 2 bars, consistent with the theory applied. By using the method here, the nozzle setting for a desired operation in an FSP process can be easily done, minimizing the time-consuming trial and error steps needed otherwise.