Browsing by Author "Adilbay, Dauren"

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Citation - WoS: 6
Citation - Scopus: 6
Skull base surgery for malignant tumors: The 2nd international collaborative study (1995-2015)
(Wiley, 2024) Shah, Jatin P.; Levyn, Helena; Valero, Cristina; Adilbay, Dauren; Eagan, Alana; Zheng, Junting; Hanna, Ehab
BackgroundThe current study presents the effort of a global collaborative group to review the management and outcomes of malignant tumors of the skull base worldwide.Patients and methodsA total of 28 institutions contributed data on 3061 patients. Analysis evaluated clinical variables, survival outcomes, and multivariable factors associated with outcomes.ResultsThe median age was 56 years (IQR 44-67). The open surgical approach was used in 55% (n = 1680) of cases, endoscopic resection was performed in 36% (n = 1087), and the combined approach in 9.6% (n = 294). With a median follow-up of 7.1 years, the 5-year OS DSS and RFS were 65%, 71.7% and 53%, respectively. On multivariable analysis, older age, comorbidities, histology, dural/intracranial involvement, positive margins, advanced stage, and primary site were independent prognostic factors for OS, DSS, and RFS. Adjuvant RT was a protective prognostic factor.ConclusionThe progress across various disciplines may have contributed to improved OS and DSS in this study compared to previous reports.
Skull Base Surgery in the Pediatric Population-The 2nd International Collaborative Study (1995-2015)
(Wiley, 2026) Fliss, Dan M.; Ungar, Omer J.; Levyn, Helena; Valero, Cristina; Adilbay, Dauren; Eagan, Alana; Shah, Jatin P.
Background The current study presents the efforts of a global collaborative group to review the management and outcomes of malignant tumors of the skull base in the pediatric population worldwide.Patients and Methods A total of 28 institutions contributed data on 3061 patients. From this, there were 64 pediatric patients (2.1%). Clinical variables, overall and disease-free survival (OS and DFS) outcomes, and multivariable factors associated with outcome were evaluated.Results The male-to-female ratio was 37:27 and the median [IQR] age at diagnosis was 14.0 [9.6-16.0] years. The most common malignancy was sarcoma (57.8%), followed by esthesioneuroblastoma (25.0%) and carcinoma (17.2%). Negative margins were achieved in 53.1% children. Dural invasion was associated with reduced OS and DFS. Adjuvant radiotherapy was associated with improved survival outcomes.Conclusions Open approaches were widely used for pediatric skull base tumor resection in the period between 1995 and 2015 but we saw a rise in the use of endoscopic and combined techniques by the end of the period covered by this study. Our results may represent a transitional era in which alternative endoscopic techniques continue to expand.