The Effect of Combined Hydrolyzed Type 2 Collagen, Methylsulfonylmethane, Glucosamine Sulfate and Chondroitin Sulfate Supplementation on Knee Osteoarthritis Symptoms

dc.authorid Demirci Coban, Aysegul/0000-0003-3454-3639
dc.authorid Cinar, Ece/0000-0002-9710-1582
dc.authorid yaman, ayşegül/0000-0001-8097-4208
dc.authorwosid Demirci Coban, Aysegul/KBR-2359-2024
dc.authorwosid Cinar, Ece/ABG-9016-2020
dc.authorwosid yaman, ayşegül/ABC-6906-2021
dc.authorwosid Dalyan, Meltem/HHZ-4436-2022
dc.contributor.author Ayhan, Fikriye Figen
dc.contributor.author Coban, Aysegul Demirci
dc.contributor.author Karasu, Ayca Utkan
dc.contributor.author Karaoglan, Belgin
dc.contributor.author Cinar, Ece
dc.contributor.author Eyigor, Sibel
dc.contributor.author Dalyan, Meltem
dc.date.accessioned 2024-07-05T15:23:43Z
dc.date.available 2024-07-05T15:23:43Z
dc.date.issued 2024
dc.department Atılım University en_US
dc.department-temp [Ayhan, Fikriye Figen; Coban, Aysegul Demirci] Atilim Univ, Dept Phys Med & Rehabil, Fac Med, Ankara, Turkiye; [Coban, Aysegul Demirci] Medicana Int Ankara Hosp, Dept Phys Med & Rehabil, Ankara, Turkiye; [Karasu, Ayca Utkan; Karaoglan, Belgin] Atilim Univ, Dept Therapy & Rehabil, Vocat Sch Hlth Serv, Ankara, Turkiye; [Cinar, Ece; Eyigor, Sibel] Gazi Univ, Dept Phys Med & Rehabil, Fac Med, Ankara, Turkiye; [Uzun, Oznur; Senlikci, Huma Boluk; Dalyan, Meltem] Ege Univ, Fac Med, Dept Phys Med & Rehabil, Izmir, Turkiye; [Borman, Pinar] Univ Hlth Sci, Dept Phys Med & Rehabil, Ankara Bilkent City Hosp, Ankara, Turkiye; [Vural, Secil; Kaplan, Basak Mansiz] Ankara Bilkent City Hosp, Phys Therapy & Rehabil Hosp, Subacute Rehabil Clin, Ankara, Turkiye; [Yaman, Aysegul] Private Koru Hosp, Dept Phys Med & Rehabil, Ankara, Turkiye; [Kavak, Songul Keskin] Univ Hlth Sci, Gulhane Training & Res Hosp, Dept Phys Med & Rehabil, Ankara, Turkiye; [Aktekin, Lale] Dr Abdurrahman Yurtaslan Ankara Oncol Training & R, Dept Phys Med & Rehabil, Ankara, Turkiye; [Cakit, Burcu Duyur; Kandasoglu, Habibe] Ankara Yildirim Beyazit Univ, Dept Phys Med & Rehabil, Fac Med, Ankara, Turkiye; [Kaplan, Basak Mansiz] Univ Hlth Sci, Ankara Training & Res Hosp, Dept Phys Med & Rehabil, Turkiye, Ankara, Turkiye; [Ayhan, Fikriye Figen] Ankara Medipol Univ, Dept Ergo Therapy, Sch Hlth Sci, Ankara, Turkiye; [Ayhan, Fikriye Figen] Atilim Univ, Fizik Tedavi & Rehabil Anabilim Dali, Tip Fak, TR-06830 Ankara, Turkiye en_US
dc.description Demirci Coban, Aysegul/0000-0003-3454-3639; Cinar, Ece/0000-0002-9710-1582; yaman, ayşegül/0000-0001-8097-4208; en_US
dc.description.abstract Objectives: This study aimed to evaluate the effects of the combined hydrolyzed type 2 collagen, methylsulfonylmethane (MSM), glucosamine sulfate (GS), and chondroitin sulfate (CS) supplement on knee pain intensity in patients with knee osteoarthritis (OA).Patients and methods: This multicenter, observational, noninterventional study included 98 patients (78 females, 20 males; mean age: 52.8 +/- 6.5 years; range, 40 to 64 years) who had Grade 1-3 knee OA between May 2022 and November 2022. The patients were prescribed the combination of hydrolyzed type 2 collagen, MSM, GS, and CS as a supplement for knee OA. The sachet form of the combined supplement containing 1250 mg hydrolyzed type 2 collagen, 750 mg MSM, 750 mg GS, and 400 mg CS was used once daily for two consecutive months. Patients were evaluated according to the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Visual Analog Scale (VAS)-pain, and Health Assessment Questionnaire (HAQ). Patients were scheduled to visit for follow-up four weeks (Visit 2) and eight weeks (Visit 3) after Visit 1 (baseline; day 0 of the study).Results: For the VAS-pain, WOMAC, WOMAC-subscale, and HAQ scores, the differences in improvement between the three visits were significant (p<0.001 for all). The patient compliance with the supplement was a median of 96.77%, both for Visit 2 and Visit 3. Conclusion: The combination of hydrolyzed type 2 collagen, MSM, GS, and CS for eight weeks in knee OA was considered an effective and safe nutritional supplement. en_US
dc.description.sponsorship Eczacimath;basimath; Ilac Pazarlama, Istanbul, Turkiye en_US
dc.description.sponsorship This study was funded by Eczac & imath;bas & imath; Ilac Pazarlama, Istanbul, Turkiye. en_US
dc.identifier.citationcount 0
dc.identifier.doi 10.5606/tftrd.2024.1373
dc.identifier.issn 2587-1250
dc.identifier.uri https://doi.org/10.5606/tftrd.2024.1373
dc.identifier.uri https://hdl.handle.net/20.500.14411/2347
dc.identifier.wos WOS:001150216800001
dc.institutionauthor Çoban, Ayşegül Demirci
dc.institutionauthor Ayhan, Fikriye Figen
dc.language.iso en en_US
dc.publisher Baycinar Medical Publ-baycinar Tibbi Yayincilik en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Chondroitin sulfate en_US
dc.subject function en_US
dc.subject glucosamine sulfate en_US
dc.subject osteoarthritis of the knee en_US
dc.subject pain en_US
dc.subject type 2 collagen en_US
dc.title The Effect of Combined Hydrolyzed Type 2 Collagen, Methylsulfonylmethane, Glucosamine Sulfate and Chondroitin Sulfate Supplementation on Knee Osteoarthritis Symptoms en_US
dc.type Article en_US
dc.wos.citedbyCount 0
dspace.entity.type Publication
relation.isAuthorOfPublication 84d67d7f-bdf4-4eb1-b54d-553e340e5c80
relation.isAuthorOfPublication a89d8956-de26-456d-8404-49ddb4d417bf
relation.isAuthorOfPublication.latestForDiscovery 84d67d7f-bdf4-4eb1-b54d-553e340e5c80

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