Sarıçam, Ersin
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Name Variants
Ersin, Saricam
Saricam E.
S.,Ersin
Saricam, Ersin
Sariçam E.
E.,Sarıçam
Ersin, Sariçam
S., Ersin
E., Saricam
Sarıçam, Ersin
Ersin, Sarıçam
E.,Saricam
E., Sarıçam
Sarıçam,E.
E.,Sariçam
E., Sariçam
Sariçam, Ersin
Saricam,E.
Saricam E.
S.,Ersin
Saricam, Ersin
Sariçam E.
E.,Sarıçam
Ersin, Sariçam
S., Ersin
E., Saricam
Sarıçam, Ersin
Ersin, Sarıçam
E.,Saricam
E., Sarıçam
Sarıçam,E.
E.,Sariçam
E., Sariçam
Sariçam, Ersin
Saricam,E.
Job Title
Doçent Doktor
Email Address
ersin.saricam@atilim.edu.tr
ORCID ID
Scopus Author ID
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID
Scholarly Output
6
Articles
6
Citation Count
36
Supervised Theses
0
6 results
Scholarly Output Search Results
Now showing 1 - 6 of 6
Article Citation Count: 15Laboratory and Imaging Evaluation of Cardiac Involvement in Patients with Post-Acute COVID-19(Dove Medical Press Ltd, 2021) Sarıçam, Ersin; Sarıyıldız, Gülçin Türkmen; Can, Nalan; Can, Nalan; Dursun, Ali Doğan; Gonullu, Ugur; Gönüllü, Uğur; Anesthesia Program; Basic SciencesBackground: In the post-acute COVID-19 syndrome, many patients suffer from palpitations, effort-associated fatigue, and even sudden death. The mechanism of heart involvement in this syndrome is uncertain. The main purpose of the study was to identify possible cardiac involvement causes in patients with post-acute COVID-19 by using biomarkers such as NT-proBNP and nitric oxide (NO) and cardiac imaging modalities. Methods: In this cross-sectional study, a total of 105 participants were included according to the existence of symptoms, and 40 of these participants were asymptomatic patients. The ages of the participants ranged from 20 to 50 years. All patients were healthy before COVID-19. The symptoms were defined as palpitations and/or fatigue association with exercise in post-acute COVID-19 term. The comparison of the two groups was made by using biochemical parameters (NT-proBNP, Troponin I, NO) and imaging techniques (echocardiography, cardiovascular magnetic resonance (CMR) and cardiac positron emission tomography (PET)). Results: The symptomatic patients had higher NT-proBNP levels compared with asymptomatic patients (132.30 +/- 35.15; 76.86 +/- 16.79, respectively; p < 0.001). Interestingly, the symptomatic patients had lower NO levels than asymptomatic patients (9.20 +/- 3.08; 16.15 +/- 6.02, respectively; p < 0.001). Echocardiography and CMR were normal. However, we found regional increased 18F-FDG uptake on cardiac PET to be compatible with myocardial fatigue. Conclusion: We found elevated NT-proNBP levels, low serum NO levels, and increased 18F-FDG uptake on cardiac PET in post-acute COVID syndrome. Cardiac PET could replace or be added to CMR for detecting subtle subacute/chronic myocarditis. The follow-up of patients with post-acute COVID-19 could target the possibility of risk of heart failure.Article Citation Count: 0New ECG Algorithm for the Prediction of Culprit Vessel in Acute Myocardial Infarction Involving Lateral Part of the Ventricle: Ilkay Classification(Dove Medical Press Ltd, 2023) Sarıçam, Ersin; Erdol, Mehmet Akif; Bozkurt, Engin; Ilkay, Erdogan; Cantekin, Omer FarukBackground: Isolated lateral myocardial infarction sometimes does not meet ST-segment elevation myocardial infarction (STEMI) criteria according to contiguous leads. This condition could cause late diagnosis and the need for revascularization therapy.Aim: To accurately predict the occlusion of lateral surface of the left ventricle, we defined a new electrocardiogram (ECG) algorithm by using angiographic and electrocardiographic correlations.Methods: This was a retrospective, multicenter observational study. The study population consisted of 200 patients with STEMI affecting lateral surface of myocardium, between 2021 and 2022. According to the coronary angiography results, we identified 74 eligible patients for study protocol. The study patients were divided into two groups: isolated DB (14 patients) or circumflex obtuse marginal group (60 patients).Results: ST depression in lead V2 had high positive predictive values for the prediction of obtuse marginal occlusion (positive predictive values (PPV), 100%; negative predictive value (NPV), 90%). ST elevation in V2 in ECG, in conjunction with ST depression in lead III had high positive predictive values for prediction of diagonal branch of LAD. Moreover, the presence of hyperacute T wave (& GE;10 mm) in lead V2 and & GE;2 mm ST depression in lead III had large diagonal branch of LAD (PPV, 98%; NPV, 100%). However, <10 mm T wave in lead V2 and <2 mm ST depression in lead III had small diagonal branch of LAD.Conclusion: We comprehensively classified the lateral STEMI definition through new electrocardiographic scheme as Ilkay classification, whereby we could accurately predict infarct-related artery and its occlusion level in lateral myocardial infarction.Article Citation Count: 0Clinical and Laboratory Evaluation of Acute Pericarditis Associated with Antinuclear Antibodies Positivity(Bentham Science Publ Ltd, 2023) Sarıçam, Ersin; Sarıyıldız, Gülçin Türkmen; Özyer, Eşref Umut; Sariyildiz, Gulcin Turkmen; Dursun, Ali Doğan; Bozkurt, Engin; Cantekin, Omer Faruk; Anesthesia Program; Basic SciencesBackground Up to 30% of patients with acute pericarditis develop recurrent pericarditis. Acute pericarditis may be a manifestation of an underlying systemic autoimmune disease. Therefore, we evaluated the characteristics of patients with acute pericarditis according to antinuclear antibodies (ANA) positivity/negativity. Methods Participants with acute pericarditis and negative ANA (n=29), recurrent pericarditis with positive ANA (n=30) and healthy controls (n=11) were examined. The groups were compared using serum parameters (ANA, C-reactive protein, leucocyte count, erythrocyte sedimentation rate, total antioxidant status, nitric oxide (NO), and oxidative stress index (OSI)) and imaging techniques (electrocardiogram, echocardiography, cardiovascular magnetic resonance, and venous Doppler ultrasound). Results In females, acute pericarditis associated with ANA occurred more frequently (p<0.001). ANA-positive acute pericarditis had significantly lower NO and OSI (p<0.05 and p<0.001, respectively) and pericardial inflammation on magnetic resonance. We found a pulmonary embolism in one patient with positive ANA. Slow venous flow (SVF) occurred more often in acute pericarditis associated with ANA than in the ANA-negative group on venous ultrasound (p<0.05). The prevalence of positive ANAs was 1.6 times higher among SVF patients than in controls. Conclusion This study suggests that acute pericarditis associated with ANA is more common in middle-aged females. SVF and lower oxidative stress tests were more common in patients with ANA-associated acute pericarditis. Acute pericarditis associated with ANA could be considered as a hypercoagulable state. Therefore, all newly diagnosed pericarditis patients (especially females) should be checked for ANA positivity. Awareness of this coexistence should be promptly addressed to establish management strategies.Article Citation Count: 15Laboratory and imaging evaluation of cardiac involvement in patients with post-acute covid-19(Dove Medical Press Ltd, 2021) Can, Nuray; Gönüllü, Uğur; Sarıyıldız,G.T.; Sarıçam, Ersin; Dursun, Ali Doğan; Sarıyıldız, Gülçin Türkmen; Ünlü,M.; Department of Electrical & Electronics Engineering; Anesthesia Program; Basic SciencesBackground: In the post-acute COVID-19 syndrome, many patients suffer from palpitations, effort-associated fatigue, and even sudden death. The mechanism of heart involvement in this syndrome is uncertain. The main purpose of the study was to identify possible cardiac involvement causes in patients with post-acute COVID-19 by using biomarkers such as NT-proBNP and nitric oxide (NO) and cardiac imaging modalities. Methods: In this cross-sectional study, a total of 105 participants were included according to the existence of symptoms, and 40 of these participants were asymptomatic patients. The ages of the participants ranged from 20 to 50 years. All patients were healthy before COVID-19. The symptoms were defined as palpitations and/or fatigue association with exercise in post-acute COVID-19 term. The comparison of the two groups was made by using biochemical parameters (NT-proBNP, Troponin I, NO) and imaging techniques (echocardiography, cardiovascular magnetic resonance (CMR) and cardiac positron emission tomography (PET)). Results: The symptomatic patients had higher NT-proBNP levels compared with asymptomatic patients (132.30±35.15; 76.86±16.79, respectively; p < 0.001). Interestingly, the symptomatic patients had lower NO levels than asymptomatic patients (9.20±3.08; 16.15 ±6.02, respectively; p < 0.001). Echocardiography and CMR were normal. However, we found regional increased 18F-FDG uptake on cardiac PET to be compatible with myocardial fatigue. Conclusion: We found elevated NT-proNBP levels, low serum NO levels, and increased 18F-FDG uptake on cardiac PET in post-acute COVID syndrome. Cardiac PET could replace or be added to CMR for detecting subtle subacute/chronic myocarditis. The follow-up of patients with post-acute COVID-19 could target the possibility of risk of heart failure. © 2021 Sarıçam et al. This work is published and licensed by Dove Medical Press Limited.Article Citation Count: 0Akut kalp yetmezlikli hastalarda kılavuz tedavi: sol ventrikül doluş bulguları ve NT-proBNP(2020) Sarıçam, Ersin; Öcal, ArslanAmaç: N-terminal pro B tip natriüretik peptid akut kalp yetmezliğinde sıklıkla kullanılır. Bu çalışmada, akut kalp yetmezlikli hastaların Doppler transmitral akım parametrelerinin hastaneye kabul ve taburculukta N-terminal pro B tip natriüretik peptid gibi faydalı bir yaklaşım olup olamayacağını araştırdık. Gereç ve Yöntem: Prospective randomize tasarlanan bu çalışma Ekim 2019-Mart 2020 arası acil bölümüne kabul edilen 57 hastaya kapsamaktadır. Tüm hastalar New York Heart Association sınıf IV olup sinüs ritminde ve önceden dilate kardiyomiyopati tanısı almışlardı. Hastalara giriş ve taburculukta transtorasik ekokardiyografi ile sol ventrikül diyastolik doluş paternleri değerlendirildi. Giriş ve çıkış N-terminal pro B tip natriüretik peptid seviyeleri sol venrtrikül doluş bulguları ile karşılaştırıldı. Bulgular: Ortalama yaş 64,94±5,56 idi. Girişte tüm hastaların sol ventrikül doluş paternleri restriktif tip doluş bozukluğu idi. Taburculukta 46 hasta anormal relaksasyon bozukluğu (Tip I), 11 hasta pseudonormal doluş bozukluğu (Tip II) vardı. N-terminal pro B tip natriüretik peptid seviyeleri girişte 8004,75±743 pg/mL, taburculukta 1645,17±104,58 pg/mL idi. Ortalama e/e’ oranı girişte 14,83±0,25 taburculukta 7,70±0,14 idi. Ortalama E/A oranı girişte 2,51±0,35 taburculukta 1,42±0,33 idi. Anormal relaksasyon tipte N-terminal pro B tip natriüretikpeptidseviyeleri 1440,43±144,75 pg/mL, oysa pseudonormal pattern de N-terminal pro B tip natriüretik peptid seviyeleri 1957,60±64,00 pg/mL (p=0,003). Sonuç: Akut kalp yetmezlikli hastalarda sol ventrikül doluş paternleri N-terminal pro B tip natriüretik peptid rehberliği gibi başarılı bir şekilde kullanılabileceğini göstermiştir.Article Citation Count: 6The Evaluation of Oxidative Stress in the Young Adults with COVID-19 mRNA Vaccines Induced Acute Pericarditis- Myopericarditis(Dove Medical Press Ltd, 2022) Sarıçam, Ersin; Sarıyıldız, Gülçin Türkmen; Sariyildiz, Gulcin Turkmen; Dursun, Ali Doğan; İşcanlı, Murat Doğan; Anesthesia Program; Basic SciencesBackground: During COVID-19 pandemic, several vaccines have been developed such as mRNA vaccines. However, acute pericarditis and myocarditis/myopericarditis cases have been described after mRNA vaccination. The mechanism for the development of cardiac involvement is unknown. Potential mechanism for oxidative stress associated with vaccine-induced heart involvement is unidentified. This study aimed to examine the role of oxidative stress and the heart involvement in young adults vaccinated with COVID-19 mRNA vaccines. Methods: In this cross-sectional study, a total of 23 participants were included and 10 of these participants were asymptomatic patients (control group). Comparison of the cardiac involvement and control group was made by using troponin I, C-reactive protein (hsCRP), D-dimer levels, and oxidative stress tests including nitric oxide, and imaging techniques (ECG, echocardiography, cardiovascular magnetic resonance). Results: The median age of acute pericarditis group (10 patients) was 22 years (Q1-Q3: 18.5-31), and the mean age was 24.4 +/- 7.5 years. The median age of myopericarditis group (3 patients) was 22 years (Q1-Q3 18.0-25.0), and the mean age was 21.6 +/- 3.5 years. All the myopericarditis cases were male. The patients with myopericarditis had higher troponin I level, hsCRP, and D-dimer levels (troponin I level; 1600.00 ng/mL; D-dimer; 1.20 mu g/mL, hsCRP; 3.0 mg/L, respectively; p < 0.05). Serum nitric oxide levels and OSI (total oxidant status, H2O2/total antioxidant status) were lower in myopericarditis group than the control and acute pericarditis group (p < 0.05). This shows inflammatory and procoagulant state. Conclusion: Vaccine-induced myopericarditis cases are associated with oxidative stress test abnormality (abnormal NO, OSI levels). However, there is no relationship between NO levels and other oxidative stress tests difference in vaccine-induced acute pericarditis. It is thought that vaccine-induced pericarditis and myopericarditis could have different pathogenesis. This could make it necessary to reassess the second dose of vaccination for vaccine-induced cardiac involvement cases.
