Araz, MineSoydal, CigdemOzkan, ElginSen, ElifNak, DemetKucuk, Ozlem N.Kir, K. Metin2024-07-052024-07-0520221824-47851827-193610.23736/S1824-4785.19.03169-82-s2.0-85128606953https://doi.org/10.23736/S1824-4785.19.03169-8https://hdl.handle.net/20.500.14411/1836Araz, Mine/0000-0001-6467-618X; Soydal, Cigdem/0000-0002-6199-8551; GONULLU, UGUR/0000-0002-4360-7297; SEN, ELIF/0000-0001-9656-131XBACKGROUND: Maximum standardized uptake value (SUVmax) is the primary quantitave parameter given in 18F-FDG PET/CT reports. Calculations derived from three dimensional metabolic volumetric images have been proposed to be more successful than SUVmax alone in prognostification with a lower interobserver variability in many cancers. We aimed to determine the prognostic value of metabolic parameters derived from 18F-FDG PET/CT studies in small cell lung cancer (SCLC) patient population with a long follow-up time. METHODS: In this study, 38 consecutive SCLC patients (34M, 4F, age:65.76 +/- 8.18 years) who were referred to 18F-FDG PET/CT for staging between October 2006-January 2011 were included. SUVmax, SUVmean, SUVpeak, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were calculated. Overall survival (OS) was calculated from the date of the initial PET/CT to death from any cause. Survival tables were obtained and Kaplan Meier curves were reconstructed. Mantel-Cox regression analysis was performed in order to investigate if any of these parameters have an effect on survival along with other clinical risk factors. RESULTS: Median SUVmax, SUVmean, SUVpeak, MTV, TLG and LDH values were calculated as 13.9 g/dL, 6.4 g/dL,10.69 g/dL, 147 cm(3), 1898.52 and 375U/L respectively. Median follow-up was 761.23 +/- 873.21 days (25.37 months, range:110-3338 days). Since basal 18F-FDG PET/CT scans, all patients were lost in the follow-up except for two patients. MTV was a significant prognostic factor in SCLC patients. Estimated mean survival times were 261.0 +/- 45.6 (95% CI: 171.6-350.3) days in patients with MTV value above the calculated median 147, and 577.0 +/- 124.0 (95% CI: 333.7-820.2) days in patients with MTV<147. The difference was statistically significant with a P=0.037. CONCLUSIONS: Baseline whole body MTV reflecting total tumor load is a prognostic index in SCLC. SUV is insufficient to predict prognosis.eninfo:eu-repo/semantics/closedAccessCarcinomanon-small-cell lungPositron-emission tomographyPrognosisArticleQ4Q26616166WOS:000782640200007312712684