Nasseri, BehzadKocum, Ismail CengizSeymen, Cemile MerveRabiee, Navid2024-07-052024-07-052019121751-87411751-875X10.1049/iet-nbt.2019.00662-s2.0-85070412178https://doi.org/10.1049/iet-nbt.2019.0066https://hdl.handle.net/20.500.14411/3287Rabiee, Mohammad/0000-0003-1180-8729; Rabiee, Navid/0000-0002-6945-8541; SEYMEN, CEMİLE MERVE/0000-0002-8945-3801; Nasseri, Behzad/0000-0003-3634-8327In present study, the effective penetration of radiofrequency (RF) induced gold decorated iron oxide nanoparticles (GS@IONPs) hyperthermia was investigated. The effective penetration depth of RF also the damage potency of hyperthermia was evaluated during histopathology observations which were done on the chicken breast tissue and hepatocellular carcinoma (HCC) models. The thermal damages are well- documented in our previous cellular study which was engaged with potency of RF hyperthermia in Epithelial adenocarcinoma (MCF-7) and fibroblast (L-929) cells deaths [1]. In recent work, PEGylated iron oxide nanoparticles (IONPs) were used as base platform for gold magnetic nanoparticles (GS@IONPs) formation. The 144.00015 MHz, 180W RF generator was applied for stimulating the nanoparticles. The chicken breast tissue and the hepatocellular tumor model was considered in the experimental section. In histology studies, the structural changes also the effective penetration depth of RF induced nanoparticles was observed through microscopic monitoring of the tissue slices in histology observations (Gazi medical school). The highest damage level was seen in 8.0 mu m tissue slices where lower damages were seen in depth of 1.0 cm and more inside tissue. The histology observations clarified the effective penetration depth of RF waves and irreversible damages in the 2.0 cm inside the tissue.eninfo:eu-repo/semantics/openAccessnanomedicinetumoursbiomedical materialscellular biophysicsnanoparticlesgoldcancerhyperthermiamagnetic particlesiron compoundsradiation therapyAu-Fe3O4depth 10 cmdepth 80 mumpower 1800 Wsize 20 cmfrequency 14400015 MHzmicroscopic monitoringstructural changeshepatocellular tumour modelstanding wave ratiopropylene glycolthermal damageshepatocellular carcinoma modelsradiofrequency hyperthermiananoparticle dispersiontissue alterationsmodified tissuesgold shell magnetic nanoparticleschicken breast tissuegold-coated iron oxide nanoparticlespathology observationseffective penetration depthhistology observationstissue slicesArticleQ3Q2136634639WOS:00047891760001431432798