Saltoglu, NeseSurme, SerkanEzirmik, ElifKadanali, AytenKurt, Ahmet FurkanSahin Ozdemir, MeryemKinikli, Sami2024-07-052024-07-05202381534-73461552-694110.1177/153473462110041412-s2.0-85104645892https://doi.org/10.1177/15347346211004141https://hdl.handle.net/20.500.14411/2083Sahin Ozdemir, Meryem/0000-0002-3928-3840; altay, fatma aybala/0000-0002-7149-2968; Sürme, Serkan/0000-0001-7239-1133; acar, ali/0000-0001-6478-2206; Kurt, Ahmet Furkan/0000-0002-7454-7557; Acar, Ali/0000-0003-2008-5112We aimed to determine pathogen microorganisms, their antimicrobial resistance patterns, and the effect of initial treatment on clinical outcomes in patients with diabetic foot infection (DFI). Patients with DFI from 5 centers were included in this multicenter observational prospective study between June 2018 and June 2019. Multivariate analysis was performed for the predictors of reinfection/death and major amputation. A total of 284 patients were recorded. Of whom, 193 (68%) were male and the median age was 59.9 +/- 11.3 years. One hundred nineteen (41.9%) patients had amputations, as the minor (n = 83, 29.2%) or major (n = 36, 12.7%). The mortality rate was 1.7% with 4 deaths. A total of 247 microorganisms were isolated from 200 patients. The most common microorganisms were Staphylococcus aureus (n = 36, 14.6%) and Escherichia coli (n = 32, 13.0%). Methicillin resistance rates were 19.4% and 69.6% in S aureus and coagulase-negative Staphylococcus spp., respectively. Multidrug-resistant Pseudomonas aeruginosa was detected in 4 of 22 (18.2%) isolates. Extended-spectrum beta-lactamase-producing Gram-negative bacteria were detected in 20 (38.5%) isolates of E coli (14 of 32) and Klebsiella spp. (6 of 20). When the initial treatment was inappropriate, Klebsiella spp. related reinfection within 1 to 3 months was observed more frequently. Polymicrobial infection (p = .043) and vancomycin treatment (p = .007) were independent predictors of reinfection/death. Multivariate analysis revealed vascular insufficiency (p = .004), hospital readmission (p = .009), C-reactive protein > 130 mg/dL (p = .007), and receiving carbapenems (p = .005) as independent predictors of major amputation. Our results justify the importance of using appropriate narrow-spectrum empirical antimicrobials because higher rates of reinfection and major amputation were found even in the use of broad-spectrum antimicrobials.eninfo:eu-repo/semantics/closedAccessdiabetic foot infectionantimicrobial resistancemultidrug-resistant organismsreinfectionmajor amputationThe Effects of Antimicrobial Resistance and the Compatibility of Initial Antibiotic Treatment on Clinical Outcomes in Patients With Diabetic Foot InfectionArticleQ3Q1222283290WOS:00064345040000133856261