Erdol, Mehmet AkifAcar, BurakErtem, Ahmet GoktugKaranfil, MustafaYayla, CagriDemirtas, KorayAkcay, Adnan Burak2024-07-052024-07-05202122211-41222347-193X10.4103/jcecho.jcecho_103_202-s2.0-85107555795https://doi.org/10.4103/jcecho.jcecho_103_20https://hdl.handle.net/20.500.14411/1983Sonmezer, Meliha Cagla/0000-0001-6529-5282; ERDINC, FATMA SEBNEM/0000-0003-3918-564X; Ataman Hatipoğlu, Çiğdem/0000-0002-1104-8232; ERDOL, Mehmet Akif/0000-0002-2721-440X; Kaya Kılıç, Esra/0000-0002-3270-4841; Erdinç, Fatma Şebnem/0000-0003-3918-564X; ACAR, BURAK/0000-0003-3217-5000; YAYLA, CAGRI/0000-0002-5302-4052Introduction: Pulmonary arterial hypertension and human immunodeficiency virus (HIV) infection is a well-known association. Pulmonary pulse transit time (pPTT) is a recent echocardiographic marker that might be used for evaluation of pulmonary arterial stiffness (PAS) in patients with HIV infection. We aimed to investigate whether pPTT elevated in patients with HIV infection compared to healthy controls and its association with echocardiographic indices of right ventricular functions. Materials and Methods: Fifty HIV (+) patients from infectious disease outpatient clinics and fifty age- and sex-matched HIV (-) healthy volunteers were enrolled in this study. pPTT was measured from pulmonary vein flow velocity as the time interval between the R-wave in the electrocardiography and corresponding peak late systolic was then calculated as the mean from two separate pw-Doppler measurements. Results: pPTT, tricuspid annular peak systolic excursion (TAPSE) and right ventricle fractional area change (FAC) were significantly lower in patients with HIV than control patients (177.1 +/- 34.9 vs. 215.7 +/- 35.7 msn, P < 0.001; 2.33 +/- 0.28 vs. 2.19 +/- 0.22, P = 0.039; 45 [4.25] vs. 41.1 [4.0], P = 0.032, respectively). pPTT was positively correlated with FAC, TAPSE and cluster of differentiation 4 count (r = 0.210; P = 0.036, r = 0.256; P = 0.041, r = 0.304; P = 0.044, respectively). Conclusion: Our study showed that pPTT, TAPSE, and right ventricle FAC levels were lower in patients with HIV infection. pPTT is an important predictor in patients with HIV expected to develop pulmonary vascular pathology.eninfo:eu-repo/semantics/openAccessEchocardiographyHIV infectionpulmonary hypertensionpulmonary pulse transit timeArticleQ3311610WOS:00065880120000234221879