Dursun, Ali DoğanKarabork, SeydaCelik, HumeyraDursun, Ali DoganAnkarali, HandanTurkoglu, Sule AydinBasic Sciences2024-07-052024-07-05202400006-92481336-034510.4149/BLL_2024_582-s2.0-85193478014https://doi.org/10.4149/BLL_2024_58https://hdl.handle.net/20.500.14411/2357Ankarali, Handan Camdeviren/0000-0002-3613-0523;OBJECTIVES: To distinguish whether idiopathic intracranial hypertension (IIH) is a condition predisposing to multiple sclerosis (MS) or an isolated disease, the current gene transcription factor Activator Protein -1 (AP -1) was evaluated with its potential to differentiate both diseases. BACKGROUND: The aim of this study was to investigate the use of AP -1 as biomarkers for the discrimination of IIH and MS. METHODS: AP -1, TNF-alpha, and IL -6 protein values in the CSF of the cases were evaluated by the ELISA method. The numerical measures of the groups and the ability of AP -1 to distinguish the groups were analyzed with the ROC curve. RESULTS: There was no difference between the groups in CSF TNF-alpha, IL -6, CSF, and serum biochemistry analyses. However, it was determined that the AP -1 concentration (pg/ml) was significantly higher in the IIH group, the sensitivity of AP -1 in separating those with IIH was 75%, and the specificity in separating those with MS was 60% in those with an AP -1 concentration of 606.5 and above. CONCLUSION: According to our results, the fact that CSF TNF-alpha and IL -6 values did not differ in IIH compared to MS revealed that IIH could not methodologically control MS, and AP -1 was a supportive parameter in differentiating both diseases (Tab. 2, Fig. 1, Ref. 31) . Text in PDF www.elis.skeninfo:eu-repo/semantics/openAccessmultiple sclerosisidiopatic intracranial hypertensionactivator protein-1cerebrospinal fluidinflammationArticleQ41256382386WOS:00123548110000438757596