Gokce,E.Akat,F.Dursun,A.D.Gunes,E.Bayram,P.Billur,D.Koc,E.Interior Architecture and Environmental DesignBasic Sciences2024-10-062024-10-06201901108-7161[SCOPUS-DOI-BELIRLENECEK-62]2-s2.0-85075919117https://hdl.handle.net/20.500.14411/9506Objectives: Eccentric contraction occurs when the muscle lengthens under tension. Damage-induced responses seen in the muscle after eccentric exercise usually experienced by sedentary individuals. This study aims to investigate muscle damage on different slopes. Methods: 32 male Wistar albino rats randomly divided into four groups: Sedentary, horizontal running, and eccentric exercise (-8°,-16°) groups. Animals ran for 90 min with the speed of 25 m/s for five days. After 48h from the last exercise, rats were sacrificed, and plasma creatine kinase (CK), heat shock protein 70 (HSP70) levels were examined. Plasma and soleus total oxidant/antioxidant status (TOS-TAS) and histological changes of soleus muscle assessed. Results: CK and HSP70 significantly increased in 16° EE group. TOS increased at 16° EE and 8° EE, but oxidative stress index (OSI) was only high at 8˚ EE group. Mononuclear cell infiltration and the angiogenesis increased in soleus after eccentric exercise, and there was a correlation with slope. Sarcomere breaks were detected in 16° EE group also in a correlation with slope. Conclusions: Consequently, sedentary individuals are vulnerable to injuries induced by eccentric contraction. Therefore, our study provides information for reconsidering rehabilitation and training programs. © 2019, International Society of Musculoskeletal and Neuronal Interactions. All rights reserved.eninfo:eu-repo/semantics/closedAccessCreatine kinaseEccentric exerciseHSP70Muscular damageSmall animal treadmillArticleQ4Q319441242131789292