Ozturk, SavasTurgutalp, KenanArıcı, MustafaÇetinkaya, HakkıAltıparmak, Mehmet RızaAydın, ZekiAteş, Kenan2024-07-052024-07-05202111300-01441303-616510.3906/sag-2011-1692-s2.0-85109970332https://doi.org/10.3906/sag-2011-169https://search.trdizin.gov.tr/tr/yayin/detay/482174/impact-of-hospital-acquired-acute-kidney-injury-on-covid-19-outcomes-in-patients-with-and-without-chronic-kidney-disease-a-multicenter-retrospective-cohort-studyAyar, Yavuz/0000-0003-4607-9220; islam, Mahmud/0000-0003-1284-916X; sezer, siren/0000-0002-7326-8388; Bakirdogen, Serkan/0000-0002-3448-0490; Sahin, Idris/0000-0002-8683-3737; Ayar, Yavuz/0000-0003-4607-9220; Dolarslan, Murside Esra/0000-0002-8669-4212; Ayar, Yavuz/0000-0003-4607-9220; ARICI, MUSTAFA/0000-0002-4055-7896; Cetinkaya, Hakki/0000-0001-9527-3885; Aydin, Zeki/0000-0001-8389-8271; Soypacaci, Zeki/0000-0003-3019-0178; Seyahi, Nurhan/0000-0001-7427-618X; Ozturk, Savas/0000-0002-0961-3810; bora, feyza/0000-0003-2379-2090; Kara, Ekrem/0000-0003-0881-7851Background/aim: Hospital-acquired acute kidney injury (HA-AKI) may commonly develop in Covid-19 patients and is expected to have higher mortality. There is little comparative data investigating the effect of HA-AKI on mortality of chronic kidney disease (CKD) patients and a control group of general population suffering from Covid-19. Materials and methods: HA-AKI development was assessed in a group of stage 3–5 CKD patients and control group without CKD among adult patients hospitalized for Covid-19. The role of AKI development on the outcome (in-hospital mortality and admission to the intensive care unit [ICU]) of patients with and without CKD was compared. Results: Among 621 hospitalized patients (age 60 [IQR: 47–73]), women: 44.1%), AKI developed in 32.5% of the patients, as stage 1 in 84.2%, stage 2 in 8.4%, and stage 3 in 7.4%. AKI developed in 48.0 % of CKD patients, whereas it developed in 17.6% of patients without CKD. CKD patients with HA-AKI had the highest mortality rate of 41.1% compared to 14.3% of patients with HA-AKI but no CKD (p < 0.001). However, patients with AKI+non-CKD had similar rates of ICU admission, mechanical ventilation, and death rate to patients with CKD without AKI. Adjusted mortality risks of the AKI+non-CKD group (HR: 9.0, 95% CI: 1.9–44.2) and AKI+CKD group (HR: 7.9, 95% CI: 1.9–33.3) were significantly higher than that of the non-AKI+non-CKD group. Conclusion: AKI frequently develops in hospitalized patients due to Covid-19 and is associated with high mortality. HA-AKI has worse outcomes whether it develops in patients with or without CKD, but the worst outcome was seen in AKI+CKD patients.Key words: Acute kidney injury, chronic kidney disease, Covid-19, hospitalization, mortalityeninfo:eu-repo/semantics/openAccessArticleQ3Q1513947961WOS:00066824490000833611868482174