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Article Citation - WoS: 5Citation - Scopus: 7G-Csf Treatment of Healthy Pediatric Donors Affects Their Hematopoietic Microenvironment Through Changes in Bone Marrow Plasma Cytokines and Stromal Cells(Academic Press Ltd- Elsevier Science Ltd, 2021) Aerts-Kaya, Fatima; Kilic, Emine; Kose, Sevil; Aydin, Gozde; Cagnan, Ilgin; Kuskonmaz, Baris; Uckan-Cetinkaya, DuyguAlthough G-CSF mobilized peripheral blood stem cell (PBSC) transplantation is commonly used in adults, bone marrow (BM) is still the preferred stem cell source in pediatric stem cell transplantation. Despite the fact that G-CSF is increasingly being used to enhance the hematopoietic stem/progenitor cell (HSPC) yield in BM transplantation (G-BM), the direct effects of G-CSF on the pediatric BM microenvironment have never been investigated. The BM hematopoietic niche provides the physical space where the HSPCs reside. This BM niche regulates HSPC quiescence and proliferation through direct interactions with other niche cells, including Mesenchymal Stromal Cells (MSCs). These cells have been shown to secrete a wide range of hematopoietic cytokines (CKs) and growth factors (GFs) involved in differentiation, retention and homing of hematopoietic cells. Here, we assessed changes in the BM microenvironment by measuring levels of 48 different CKs and GFs in G-BM and control BM (C-BM) plasma from pediatric donors. In addition, the effect of G-CSF on cell numbers and characteristics of HSPCs and MSCs was assessed. IL-16, SCGF-b, MIP-1b (all >1000 pg/mL) and RANTES (>10.000 pg/mL) were highly expressed in healthy donor pediatric BM plasma. Levels of IL-3, IL-18, GROa, MCP-3 (p<0.05) were increased in G-BM, whereas levels of RANTES (p<0.001) decreased after G-CSF treatment. We found a negative correlation with increasing age for IL2-Ra and LIF (p<0.05). In addition, a concomitant increase in the number of both hematopoietic and fibroblast colony forming units was observed, indicating that G-CSF affects both HSPC and MSC numbers. In conclusion, G-CSF treatment of healthy pediatric donors affects the hematopoietic BM microenvironment by expansion of HSPC and MSC numbers and modifying local CK and GF levels.Article Citation - WoS: 6Citation - Scopus: 6Gold and Ytterbium Interfacing Effects on the Properties of the Cdse/Yb Nanosandwiched Structures(Elsevier Science Bv, 2018) Alharbi, S. R.; Qasrawi, A. F.Owing to the performance of the CdSe as an optoelectronic material used for the production of quantum dots, photosensors and wave traps we here, in this article, report the enhancements in structural and electrical properties that arises from the nanosandwiching of a 40 nm thick Yb film between two films of CdSe (CYbC-40). The CdSe films which were deposited onto glass, Yb and Au substrates are characterized by X-ray diffraction, temperature dependent electrical conductivity and impedance spectroscopy measurements in the frequency range of 10-1800 MHz. The analysis of the XRD patterns have shown that the glass/CdSe/Yb/CdSe films exhibit larger grain size and lower strain, defect density and lower stacking faults compared to the not sandwiched CdSe. In addition, it was observed that the Yb shifts the donor states of the n-type CdSe from 0.44 to 0.29 eV leading to a modification in the built in voltage of the material. On the other hand, the design of the energy band diagram has shown the ability of the formation of the Au/CYbC-40/Yb as Schottky (SB) and the Au/CYbC-40/Au as back to back Schottky barriers (BBSB). While the SB device show low band pass filter characteristics, the BBSB device performed as band stop filters. The BBSB device exhibited negative capacitance effects with filtering features that reveal a return loss of 42 dB at similar to 1440 MHz.Article Citation - WoS: 3Citation - Scopus: 6Adult Education as a Stepping-Stone To Better Jobs: an Analysis of the Adult Education Survey in Turkey(Sage Publications inc, 2018) Cilasun, Seyit Mumin; Demir-Seker, Sirma; Dincer, N. Nergiz; Tekin-Koru, AycaThe objective of this article is to investigate whether adult education (AE) can be used as a tool in facilitating transitions to/in the labor market, using the cross-sectional Adult Education Survey of Turkey (2012). AE is defined as the nonformal education for individuals aged older than 25 years. The outcome of AE is measured by changing jobs for employed and finding a job for the unemployed. Concentrating on employed people, we analyze both the determinants and the outcome of participation in AE for the purpose of changing jobs; and second, concentrating on unemployed people, we analyze both the determinants and the outcome of participation in AE for the purpose of getting employed. We find that once young males who are already working participate in AE for changing work, independent of their education or how AE is financed, they can be successful in doing so. The results of the paper suggest that AE programs offered by the government can serve as a tool in increasing income of the less educated and the unemployed by facilitating their transition to the labor market.Article Citation - WoS: 9Citation - Scopus: 9Thermally Stimulated Current Measurements in Undoped Ga3inse4< Single Crystals(Pergamon-elsevier Science Ltd, 2011) Isik, M.; Işık, Mehmet; Gasanly, N. M.; Işık, Mehmet; Department of Electrical & Electronics Engineering; Department of Electrical & Electronics EngineeringThe trap levels in nominally undoped Ga3InSe4 crystals were investigated in the temperature range of 10-300 K using the thermally stimulated currents technique. The study of trap levels was accomplished by the measurements of current flowing along the c-axis of the crystal. During the experiments we utilized a constant heating rate of 0.8 K/s. Experimental evidence is found for one hole trapping center in the crystal with activation energy of 62 meV. The analysis of the experimental TSC curve gave reasonable results under the model that assumes slow retrapping. The capture cross-section of the trap was determined as 1.0 x 10(-25) cm(2) with concentration of 1.4 x 10(17) cm(-3). (C) 2011 Elsevier Ltd. All rights reserved.Article Citation - WoS: 5Citation - Scopus: 6An Electrochromic Polymer Based on Cyclopenta[2,1-B;3,4 Effect of a Single Atom Alteration on the Electrochemical and Optical Properties of the Polymer Backbone(Elsevier Science Sa, 2020) Tutuncu, Esra; Varlik, Bengisu; Kesimal, Busra; Cihaner, Atilla; Ozkut, Merve IcliAn electrochromic polymer, namely "poly(2,6-(3,3-didecyl-3,4-dihydro-2H-thieno [3,4-b] [1,4]dioxepin-6-yl)-4,4-dioctyl-4H-cyclopenta[2,1-b;3,4-b']dithiophene)" (P1), was electrochemically synthesized successfully, and its electrochemical and optical properties were investigated. The band gap of the polymer P1 was calculated as 1.77 eV with -5.45 eV Highest Occupied Molecular Orbital (HOMO) and -3.68 eV Lowest Unoccupied Molecular Orbital (LUMO) energy levels. The polymer P1 is bluish purple when neutralized and highly transparent greenish purple when oxidized. This color change was observed around 1.4 s between its redox states and optical contrast ratio was found to be as 49 % and 53 % with 234 cm(2)/C and 239 cm(2)/C coloration efficiencies at 590 nm and 634 nm, respectively. Moreover, the properties of this polymer were compared to its analogues and also during this comparison the effect of alteration of a single atom in the pendant unit was tried to be understood.Article Citation - WoS: 18Citation - Scopus: 18Fabrication of Al/Mgo and C/Mgo Tunneling Barriers for Tunable Negative Resistance and Negative Capacitance Applications(Elsevier Science Bv, 2013) Qasrawi, A. F.In this work, the design and characterization of magnesium oxide based tunneling diodes which are produced on Al and InSe films as rectifying substrates are investigated. It was found that when Al thin films are used, the device exhibit tunneling diode behavior of sharp valley at 0.15 V and peak to valley current ratio (PVCR) of 11.4. In addition, the capacitance spectra of the Al/MgO/C device show a resonance peak of negative capacitance (NC) values at 44.7 MHz. The capacitance and resistance-voltage characteristics handled at an ac signal frequency of 100 MHz reflected a build in voltage (V-bi) of 1.29 V and a negative resistance (NR) effect above 2.05 V. This device quality factor (Q)-voltage response is similar to 10(4). When the Al substrate is replaced by InSe thin film, the tunneling diode valley appeared at 1.1 V. In addition, the PVCR, NR range, NC resonance peak, Q and lib; are found to be 135, 0.94-2.24 and 39.0 MHz, similar to 10(5) and 1.34 V, respectively. Due to the wide differential negative resistance and capacitance voltage ranges and due to the response of the C/MgO/InSe/C device at 1.0 GHz, these devices appear to be suitable for applications as frequency mixers, amplifiers, and monostable-bistable circuit elements (MOBILE). (c) 2013 Elsevier B.V. All rights reserved.Article Factors Influencing the Transition Time From Psoriasis to Psoriatic Arthritis: A Real-World Multicenter Analysis(Springer Heidelberg, 2025) Kilic, Gamze; Kilic, Erkan; Tekeoglu, Ibrahim; Sargin, Betul; Cengiz, Gizem; Balta, Nihan Cuzdan; Nas, KemalTo identify clinical and demographic predictors associated with the timing of transition from psoriasis (PsO) to psoriatic arthritis (PsA), and to compare the characteristics of patients with concurrent PsO-PsA onset versus those with prolonged transition. A multi-center, observational study was conducted using data from the Turkish League Against Rheumatism (TLAR) network including PsA patients fulfilling CASPAR criteria. Patients were categorized into two groups: Group 1 (concurrent PsO and PsA onset within +/- 1 year) and Group 2 (prolonged transition to PsA, > 1 year after PsO). Demographic, clinical, and laboratory characteristics, disease activity, and patient-reported outcomes were compared between groups. Logistic regression was employed to determine independent predictors of prolonged transition. Among 799 patients (mean age 46.8 +/- 12.3 years), 237 (29.7%) had concurrent onset and 562 (70.3%) had a prolonged transition, with a mean PsO-to-PsA interval of 12.9 +/- 9.6 years. Depression (p = 0.005) and fatigue levels (p = 0.011) were significantly higher in patients with prolonged transition to PsA. Multivariate analysis revealed that scalp psoriasis (OR = 7.162), nail psoriasis (OR = 3.270), family history of PsO (OR = 1.813), and enthesitis ever (OR = 2.187) were associated with prolonged transition. Conversely, family history of PsA (OR = 0.421) and older age at PsO onset (OR = 0.957) predicted shorter transition. Prolonged transition from PsO to PsA is influenced by distinct clinical and demographic factors. Scalp/nail psoriasis, family history of PsO, and enthesitis ever may signal higher risk for prolonged PsA onset. Recognizing these markers can support timely referral and intervention, minimizing diagnostic delay and improving long-term patient outcomes.Article Citation - WoS: 35Citation - Scopus: 63Cybersecurity Enterprises Policies: a Comparative Study(Mdpi, 2022) Mishra, Alok; Alzoubi, Yehia Ibrahim; Gill, Asif Qumer; Anwar, Memoona JaveriaCybersecurity is a critical issue that must be prioritized not just by enterprises of all kinds, but also by national security. To safeguard an organization's cyberenvironments, information, and communication technologies, many enterprises are investing substantially in cybersecurity these days. One part of the cyberdefense mechanism is building an enterprises' security policies library, for consistent implementation of security controls. Significant and common cybersecurity policies of various enterprises are compared and explored in this study to provide robust and comprehensive cybersecurity knowledge that can be used in various enterprises. Several significant common security policies were identified and discussed in this comprehensive study. This study identified 10 common cybersecurity policy aspects in five enterprises: healthcare, finance, education, aviation, and e-commerce. We aimed to build a strong infrastructure in each business, and investigate the security laws and policies that apply to all businesses in each sector. Furthermore, the findings of this study reveal that the importance of cybersecurity requirements differ across multiple organizations. The choice and applicability of cybersecurity policies are determined by the type of information under control and the security requirements of organizations in relation to these policies.Review Citation - WoS: 3Citation - Scopus: 3Spatial Effectiveness in High-Rise Timber Towers: a Global Perspective(Mdpi, 2024) Ilgin, Huseyin Emre; Aslantamer, Ozlem NurHigh-rise timber structures signify a rising trend, thanks to their significant environmental and economic advantages that occur over their complete lifespan. Enhancing spatial effectiveness in these structures is a critical design consideration for project feasibility. Currently, there has been no comprehensive study on the space efficiency of such towers. This article analyzed 79 cases all over the world to deepen the knowledge of design features shaping spatial efficiency. The critical findings are as follows: (1) the most common architectural preferences include residential function, a centrally located service core, and prismatic arrangements; (2) the preferred structural material is composite, while a shear walled frame system is the favored structural system; (3) the average spatial efficiency and percentage of core area to GFA were recorded at 84% and 10%, ranging from the lowest values of 70% and 4% to the highest values of 95% and 21%, respectively; and (4) no significant differences were detected in the effect of core design approaches on spatial effectiveness if appropriately planned, with similar inferences drawn concerning form and the structural material used. This article will assist in developing design directions for different interested parties, including architectural designers taking part in the advancement of high-rise timber towers.Article Citation - WoS: 21Citation - Scopus: 23On (α, Ψ)-k-contractions in the Extended b-metric Space(Univ Nis, Fac Sci Math, 2018) Alqahtani, Badr; Karapinar, Erdal; Ozturk, AliIn this paper, we introduce a notion of (alpha, psi)-K-contraction in the setting of extended b-metric spaces and investigate the existence of a fixed point. The presented results generalize and unify a number of well-known fixed point theorem mainly in two distinct aspects; in the sense of the contraction conditions and in the frame of abstract spaces.
