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Review Citation - WoS: 35Citation - Scopus: 38Aptamer Hybrid Nanocomplexes as Targeting Components for Antibiotic/Gene Delivery Systems and Diagnostics: a Review(Dove Medical Press Ltd, 2020) Rabiee, Navid; Ahmadi, Sepideh; Arab, Zeynab; Bagherzadeh, Mojtaba; Safarkhani, Moein; Nasseri, Behzad; Tayebi, Lobat; Rabiee, Mohammad; Tahriri, MohammadrezaWith the passage of time and more advanced societies, there is a greater emergence and incidence of disease and necessity for improved treatments. In this respect, nowadays, aptamers, with their better efficiency at diagnosing and treating diseases than antibodies, are at the center of attention. Here, in this review, we first investigate aptamer function in various fields (such as the detection and remedy of pathogens, modification of nanoparticles, antibiotic delivery and gene delivery). Then, we present aptamer-conjugated nanocomplexes as the main and efficient factor in gene delivery. Finally, we focus on the targeted co-delivery of genes and drugs by nanocomplexes, as a new exciting approach for cancer treatment in the decades ahead to meet our growing societal needs.Review Citation - WoS: 90Citation - Scopus: 105Recommendations for Head and Neck Surgical Oncology Practice in a Setting of Acute Severe Resource Constraint During the Covid-19 Pandemic: an International Consensus(Elsevier Science inc, 2020) Mehanna, Hisham; Hardman, John C.; Shenson, Jared A.; Abou-Foul, Ahmad K.; Topf, Michael C.; AlFalasi, Mohammad; Holsinger, F. ChristopherThe speed and scale of the global COVID-19 pandemic has resulted in unprecedented pressures on health services worldwide, requiring new methods of service delivery during the health crisis. In the setting of severe resource constraint and high risk of infection to patients and clinicians, there is an urgent need to identify consensus statements on head and neck surgical oncology practice. We completed a modified Delphi consensus process of three rounds with 40 international experts in head and neck cancer surgical, radiation, and medical oncology, representing 35 international professional societies and national clinical trial groups. Endorsed by 39 societies and professional bodies, these consensus practice recommendations aim to decrease inconsistency of practice, reduce uncertainty in care, and provide reassurance for clinicians worldwide for head and neck surgical oncology in the context of the COVID-19 pandemic and in the setting of acute severe resource constraint and high risk of infection to patients and staff.Review Citation - WoS: 22Citation - Scopus: 30The Effect of £6 Cm Sized Noncavity-Distorting Intramural Fibroids on in Vitro Fertilization Outcomes: a Systematic Review and Meta-Analysis(Elsevier Science inc, 2023) Erden, Murat; Uyanik, Esra; Polat, Mehtap; Ozbek, Irem Yarali; Yarali, Hakan; Mumusoglu, SezcanImportance: The potential detrimental effects of fibroids on natural fecundity and in vitro fertilization (IVF) outcomes may be influ-enced by their size, location, and number. The impact of small noncavity-distorting intramural fibroids on reproductive outcomes in IVF is still controversial, with conflicting results.Objective(s): To determine whether women with noncavity-distorting intramural fibroids of & LE;6 cm size have lower live birth rates (LBRs) in IVF than female age-matched controls with no fibroids.Data Sources: MEDLINE, Embase, Global Health, and Cochrane Library databases were searched from inception until July 1, 2022. Study Selection and Synthesis: Women undergoing IVF with noncavity-distorting intramural fibroids & LE;6 cm constituted the study group (n = 520), whereas women with no fibroid formed the controls (n = 1392). Female age-matched subgroup analyses were performed to evaluate the impact of different cut-offs for size (& LE;6, & LE;4, and & LE;2 cm), location (the International Federation of Gynecology and Obstetrics [FIGO] type-3), and the number of fibroids on reproductive outcomes. Mantel-Haenszel odds ratios (ORs) with 95% confidence intervals (CIs) were used for outcome measures. All statistical analyses were performed using RevMan 5.4.1Main Outcome Measure(s): The primary outcome measure was LBR. Secondary outcome measures were clinical pregnancy, implan-tation, and miscarriage rates.Result(s): After adopting the eligibility criteria, 5 studies were included in the final analysis. Women with & LE;6 cm noncavity-distorting intramural fibroids had significantly lower LBRs (OR: 0.48, 95% CI: 0.36-0.65, 3 studies, I2=0; low-certainty evidence) compared with women with no fibroids. A significant reduction in LBRs was noted in & LE;4 cm but not in the & LE;2 cm subgroups. The FIGO type-3 fibroids of 2-6 cm size were associated with significantly lower LBRs. Owing to a lack of studies, the impact of the number of noncavity-distorting intramural fibroids (single vs. multiple) on IVF outcomes could not be assessed.Conclusion(s): We conclude that 2-6 cm sized noncavity-distorting intramural fibroids have a deleterious effect on LBRs in IVF. The presence of FIGO type-3 fibroids of 2-6 cm size is associated with significantly lower LBRs. Conclusive evidence from high-quality randomized controlled trials, the reference standard study design for studies of health care interventions, is needed before myomectomy might be offered in daily clinical practice to women with such small fibroids before undergoing IVF treatment. (Fertil Sterile 2023;119:996-1007. & COPY;2023 by American Society for Reproductive Medicine.)El resumen esta disponible en Espanol al final del articulo.Review Democratic Accountability, Political Order and Change: Exploring Accountability Processes in an Era of European Transformation(Wiley, 2018) Yilmaz, Gozde[No Abstract Available]Review Citation - WoS: 7Citation - Scopus: 7A Systematic Review on Classification and Assessment of Surgical Skill Levels for Simulation-Based Training Programs(Elsevier Ireland Ltd, 2023) Tonbul, Gokcen; Topalli, Damla; Cagiltay, Nergiz ErcilBackground: Nowadays, advances in medical informatics have made minimally invasive surgery (MIS) procedures the preferred choice. However, there are several problems with the education programs in terms of surgical skill acquisition. For instance, defining and objectively measuring surgical skill levels is a challenging process. Accordingly, the aim of this study is to conduct a literature review for an investigation of the current approaches for classifying the surgical skill levels and for identifying the skill training tools and measurement methods.Materials and Methods: In this research, a search is conducted and a corpus is created. Exclusion and inclusion criteria are applied by limiting the number of articles based on surgical education, training approximations, hand movements, and endoscopic or laparoscopic operations. To satisfy these criteria, 57 articles are included in the corpus of this study.Results: Currently used surgical skill assessment approaches have been summarized. Results show that various classification approaches for the surgical skill level definitions are being used. Besides, many studies are con-ducted by omitting particularly important skill levels in between. Additionally, some inconsistencies are also identified across the skill level classification studies.Conclusion: In order to improve the benefits of simulation-based training programs, a standardized interdisci-plinary approach should be developed. For this reason, specific to each surgical procedure, the required skills should be identified. Additionally, appropriate measures for assessing these skills, which can be defined in simulation-based MIS training environments, should be refined. Finally, the skill levels gained during the developmental stages of these skills, with their threshold values referencing the identified measures, should be redefined in a standardized manner.Review Citation - WoS: 65Citation - Scopus: 70Operational Research: Methods and Applications(Taylor & Francis Ltd, 2024) Petropoulos, Fotios; Laporte, Gilbert; Aktas, Emel; Alumur, Sibel A.; Archetti, Claudia; Ayhan, Hayriye; Zhao, XuyingThroughout its history, Operational Research has evolved to include methods, models and algorithms that have been applied to a wide range of contexts. This encyclopedic article consists of two main sections: methods and applications. The first summarises the up-to-date knowledge and provides an overview of the state-of-the-art methods and key developments in the various subdomains of the field. The second offers a wide-ranging list of areas where Operational Research has been applied. The article is meant to be read in a nonlinear fashion and used as a point of reference by a diverse pool of readers: academics, researchers, students, and practitioners. The entries within the methods and applications sections are presented in alphabetical order. The authors dedicate this paper to the 2023 Turkey/Syria earthquake victims. We sincerely hope that advances in OR will play a role towards minimising the pain and suffering caused by this and future catastrophes.Review Citation - WoS: 193Citation - Scopus: 205Stimulus-Responsive Sequential Release Systems for Drug and Gene Delivery(Elsevier Sci Ltd, 2020) Ahmadi, Sepideh; Rabiee, Navid; Bagherzadeh, Mojtaba; Elmi, Faranak; Fatahi, Yousef; Farjadian, Fatemeh; Hamblin, Michael R.In recent years, a range of studies have been conducted with the aim to design and characterize delivery systems that are able to release multiple therapeutic agents in controlled and programmed temporal sequences, or with spatial resolution inside the body. This sequential release occurs in response to different stimuli, including changes in pH, redox potential, enzyme activity, temperature gradients, light irradiation, and by applying external magnetic and electrical fields. Sequential release (SR)-based delivery systems, are often based on a range of different micro- or nanocarriers and may offer a silver bullet in the battle against various diseases, such as cancer. Their distinctive characteristic is the ability to release one or more drugs (or release drugs along with genes) in a controlled sequence at different times or at different sites. This approach can lengthen gene expression periods, reduce the side effects of drugs, enhance the efficacy of drugs, and induce an anti-proliferative effect on cancer cells due to the synergistic effects of genes and drugs. The key objective of this review is to summarize recent progress in SR-based drug/gene delivery systems for cancer and other diseases. (C) 2020 Elsevier Ltd. All rights reserved.Review Citation - WoS: 3Citation - Scopus: 3Lyapunov Type Inequalities for Second Order Forced Mixed Nonlinear Impulsive Differential Equations(Elsevier Science inc, 2016) Agarwal, Ravi P.; Ozbekler, AbdullahIn this paper, we present some new Lyapunov and Hartman type inequalities for second order forced impulsive differential equations with mixed nonlinearities: x ''(t) + p(t)vertical bar x(t)vertical bar(beta-1)x(t) + q(t)vertical bar x(t)vertical bar(gamma-1)x(t) = f(t), t not equal theta(i); Delta x'(t) + p(i)vertical bar x(t)vertical bar(beta-1)x(t) + q(i)vertical bar x(t)vertical bar(gamma-1) x(t) = f(i), t = theta(i), where p, q, f are real-valued functions, {p(i)}, {q(i)}, {f(i)} are real sequences and 0 < gamma < 1 < beta < 2. No sign restrictions are imposed on the potential functions p, q and the forcing term f and the sequences {p(i)}, {q(i)}, {f(i)}. The inequalities obtained generalize and complement the existing results for the special cases of this equation in the literature. (C) 2016 Elsevier Inc. All rights reserved.Review Citation - WoS: 11Citation - Scopus: 12The Importance of Media on Decision to Undergo Cosmetic Surgery Operation(Springer, 2022) Sonmez, Mehmet; Esiyok, ElifBackground How media disseminates ideal beauty, and its effect on the decision-making process of cosmetic procedures are among the most discussed topics in the literature. This study aimed to investigate the effects of media on patients' decisions to undergo cosmetic surgery. Materials and Methods Between March and September 2021, 82 patients participated in this study and informed consent was obtained from all patients. A questionnaire containing three different parts was developed by a consultant plastic surgeon and a public relations and marketing specialist, according to the literature. All statistical analyses were performed using SPSS version 22.0. Results The majority of patients underwent rhinoplasty (31.7%), breast reduction (25.6%), and breast augmentation (12.2%). Some of the patients underwent two different operations (6%). The correlation analysis results showed that, there was a medium, positive correlation between wanting to be attractive and thinking that media is an important tool in the decision to undergo cosmetic surgery (r=.307, p<.01). Want to look like people on the media and compare themselves with those showing a positive and strong correlation (r=.640, p<.01). The photographs on the magazines affected the patients aged between 40-49 and 50-59 more (chi(2)(4) = 11,378, p<.05); however, the published news on the Internet affected the younger sample (30-39 and 21-29) more than the other age groups (chi(2)(4)= 11,808, p<.05). The participants aged 30-39 and 21-29 tend to compare themselves with people on the Internet. Conclusion The study concludes that media is not only important for disseminating beauty ideals but is also an important source during decision making. However, further studies with more participants and objective scales are needed to verify our results.Review Citation - WoS: 27Citation - Scopus: 25Real-Time Biosensing Bacteria and Virus With Quartz Crystal Microbalance: Recent Advances, Opportunities, and Challenges(Taylor & Francis inc, 2023) Bonyadi, Farzaneh; Kavruk, Murat; Ucak, Samet; Cetin, Barbaros; Bayramoglu, Gulay; Dursun, Ali D. D.; Ozalp, Veli C. C.Continuous monitoring of pathogens finds applications in environmental, medical, and food industry settings. Quartz crystal microbalance (QCM) is one of the promising methods for real-time detection of bacteria and viruses. QCM is a technology that utilizes piezoelectric principles to measure mass and is commonly used in detecting the mass of chemicals adhering to a surface. Due to its high sensitivity and rapid detection times, QCM biosensors have attracted considerable attention as a potential method for detecting infections early and tracking the course of diseases, making it a promising tool for global public health professionals in the fight against infectious diseases. This review first provides an overview of the QCM biosensing method, including its principle of operation, various recognition elements used in biosensor creation, and its limitations and then summarizes notable examples of QCM biosensors for pathogens, focusing on microfluidic magnetic separation techniques as a promising tool in the pretreatment of samples. The review explores the use of QCM sensors in detecting pathogens in various samples, such as food, wastewater, and biological samples. The review also discusses the use of magnetic nanoparticles for sample preparation in QCM biosensors and their integration into microfluidic devices for automated detection of pathogens and highlights the importance of accurate and sensitive detection methods for early diagnosis of infections and the need for point-of-care approaches to simplify and reduce the cost of operation.
