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Article Citation - WoS: 33Citation - Scopus: 56Smart irrigation system for environmental sustainability in Africa: An Internet of Everything (IoE) approach(Amer inst Mathematical Sciences-aims, 2019) Adenugba, Favour; Misra, Sanjay; Maskeliunas, Rytis; Damasevicius, Robertas; Kazanavicius, EgidijusWater and food are two of the most important commodities in the world, which makes agriculture crucial to mankind as it utilizes water (irrigation) to provide us with food. Climate change and a rapid increase in population have put a lot of pressure on agriculture which has a snowball effect on the earth's water resource, which has been proven to be crucial for sustainable development. The need to do away with fossil fuel in powering irrigation systems cannot be over emphasized due to climate change. Smart Irrigation systems powered by renewable energy sources (RES) have been proven to substantially improve crop yield and the profitability of agriculture. Here we show how the control and monitoring of a solar powered smart irrigation system can be achieved using sensors and environmental data from an Internet of Everything (IoE). The collected data is used to predict environment conditions using the Radial Basis Function Network (RBFN). The predicted values of water level, weather forecast, humidity, temperature and irrigation data are used to control the irrigation system. A web platform was developed for monitoring and controlling the system remotely.Article Citation - WoS: 6Citation - Scopus: 6Multiple Sclerosis Experiences of Couples: Examination of Patient and Partner Perspectives(Sage Publications Ltd, 2022) Demirtepe-Saygili, DilekThe study aims to investigate Multiple Sclerosis (MS) experiences of couples. Using a dyadic qualitative method, separate simultaneous interviews were conducted with 20 couples, including one partner with MS. The themes resulting from content analysis were examined in two categories: Convergent (anxiety about future, acceptance of MS and MS as an accelerator of the relationship) and divergent (sexual problems, the experience of MS symptoms, the priority of the problems and untold issues). The findings revealed shared and unique perspectives of partners in the illness process, having the potential to guide the psychosocial interventions for couples living with a chronic illness.Article Citation - WoS: 1Citation - Scopus: 1Ongoing Discussion: Is Prophylactic Central Neck Dissection Necessary in Ct1a-B,2n0 Papillary Thyroid Cancer(Sage Publications Ltd, 2025) Bayir, Omer; Akan, Latif; Kizilgul, Muhammed; Ucan, Bekir; Karahan, Sevilay; Toptas, Gokhan; Korkmaz, Mehmet HakanObjective: To analyze the central lymph node metastasis (CLNM) rates of patients who underwent prophylactic central lymph node dissection (pCLND) with total thyroidectomy for cT1-2N0 papillary thyroid cancer in our clinic, to evaluate the conditions associated with lymph node metastasis, and to examine the necessity of pCLND in these patient groups.Methods: This study includes a retrospective review of the medical data of patients who underwent bilateral/unilateral central lymph node dissection (CLND) (b/uCLND) with total thyroidectomy in our center between 2013 and 2021, whose fine needle aspiration biopsy result was reported as malignant, who were detected as cT1a-1b-2N0 on thyroid and neck ultrasonography.Results: Of the 251 patients included in the study, 63 (25%) had CLNM (49 (19.5%) ipsilateral and 14 (5.5%) had contralateral CLNM). Twenty-two (20.1%) of 109 patients with cT1a, 30 (28.3%) of 106 patients with cT1b, and 11 (30.5%) of 36 patients with cT2 had CLNM, and metastasis rates increased with increasing cT category. CLNM rates increased with increasing pT category (p=0.005). CLNM was present in 21 (38.8%) of 54 patients (21.5%) with collision tumors, and metastasis rates increased significantly compared to the presence of a single histopathologic tumor (p=0.006). CLNM rates were higher in patients with multicentric tumor localization than in those with unicentric localization (p=0.006).Conclusion: Multicentricity, bilaterality, capsule invasion, collision tumors and tumors larger than 1 cm increase the risk of CLNM. uCLND for tumors larger than 1 cm, bCLND for tumors larger than 2 cm can be considered. We believe that patients with unilateral CLNM also have an increased risk of contralateral metastasis.Article Citation - WoS: 8Citation - Scopus: 9Refugees' Opinions About Healthcare Services: a Case of Turkey(Mdpi, 2021) Tengilimoglu, Dilaver; Zekioglu, Aysu; Budak, Fatih; Eris, Hilseyin; Younis, MustafaBackground: Migration is one of the most important social events in human history. In recent years, Turkey hosted a high number of asylum seekers and refugees, primarily because of continuing wars and radical social changes in the Middle East. Methods: Using a random sampling method, Syrian refugees aged 18 and over, who can communicate in Turkish, were reached via personal contact and a total of 714 refugees participated in the study voluntarily. Results: Turkey has mounted with some success and to point out that even though participating refugees in both provinces are young and healthy, almost 50% have bad or worse health status, 61% have chronic diseases, and 55% need regular medication. Participating refugees living in Sanliurfa stated that 'Hospitals are very clean and tidy.' (3.80 +/- 0.80). The answers given to the following statements had the highest mean for the participating refugees living in Kilis; 'Hospitals are clean and tidy.' (3.22 +/- 1.25). Conclusion: Due to financial and human resource deficiencies, there are problems in providing preventive and therapeutic health services, especially to refugees living outside the refugee camps in bad conditions. It is important that refugees are encouraged to apply to family health and community health centers in this context.Article Citation - WoS: 72Citation - Scopus: 72Depression, Substance Use and Hiv Risk in a Probability Sample of Men Who Have Sex With Men(Pergamon-elsevier Science Ltd, 2013) Fendrich, Michael; Avci, Ozgur; Johnson, Timothy P.; Mackesy-Amiti, Mary EllenThe persistent HIV epidemic among men who have sex with men (MSM) suggests that continued research on factors associated with risky sexual behavior is necessary. Drawing on prior literature, the role of depression and substance use in HIV risk is also inconclusive. Generalizability of past findings may also be limited to the extent that research has not employed probability samples. Here we report on one of the few probability samples of MSM to examine the role of depressive symptoms and substance use on risky sexual behavior (RSB). Multinomial logistic regression analysis suggested that depression and substance use are independently linked to our risk measure, such that those reporting high levels of depressive symptoms or substance use were more likely to report both unprotected receptive anal intercourse and unprotected insertive anal intercourse, and sex with a risky partner. Implications for prevention and treatment are discussed. (C) 2012 Elsevier Ltd. All rights reserved.Book Part Citation - WoS: 3Citation - Scopus: 4Stem Cell Applications in Lysosomal Storage Disorders: Progress and Ongoing Challenges(Springer international Publishing Ag, 2021) Kose, S.; Aerts-Kaya, F.; Cetinkaya, D. Uckan; Korkusuz, P.; Uçkan Çetinkaya, DuyguLysosomal storage disorders (LSDs) are rare inborn errors of metabolism caused by defects in lysosomal function. These diseases are characterized by accumulation of completely or partially degraded substrates in the lysosomes leading to cellular dysfunction of the affected cells. Currently, enzyme replacement therapies (ERTs), treatments directed at substrate reduction (SRT), and hematopoietic stem cell (HSC) transplantation are the only treatment options for LSDs, and the effects of these treatments depend strongly on the type of LSD and the time of initiation of treatment. However, some of the LSDs still lack a durable and curative treatment. Therefore, a variety of novel treatments for LSD patients has been developed in the past few years. However, despite significant progress, the efficacy of some of these treatments remains limited because these therapies are often initiated after irreversible organ damage has occurred. Here, we provide an overview of the known effects of LSDs on stem cell function, as well as a synopsis of available stem cell-based cell and gene therapies that have been/are being developed for the treatment of LSDs. We discuss the advantages and disadvantages of use of hematopoietic stem cell (HSC), mesenchymal stem cell (MSC), and induced pluripotent stem cell (iPSC)-related (gene) therapies. An overview of current research data indicates that when stem cell and/or gene therapy applications are used in combination with existing therapies such as ERT, SRT, and chaperone therapies, promising results can be achieved, showing that these treatments may result in alleviation of existing symptoms and/or prevention of progression of the disease. All together, these studies offer some insight in LSD stem cell biology and provide a hopeful perspective for the use of stem cells. Further development and improvement of these stem cell (gene) combination therapies may greatly improve the current treatment options and outcomes of patients with a LSD.Article Which Design Tolerates Rotational Mismatch Better in Unicompartmental Knee Arthroplasty: Fixed or Mobile Bearing?(Acta Medica Belgica, 2022) Emre, Fahri; Kilic, Erden; Kaya, Ozgur; Uysal, Ozgur Selim; Cay, Nurdan; Bozkurt, Murat; Erşen, ÖmerUnicompartmental knee arthroplasty is an effective method for the treatment of medial compartment osteoarthritis. However, appropriate surgical technique and optimum implant positioning are crucial for a satisfactory outcome. This study aimed to demonstrate the relation between the clinical scores and the alignment of the components in UKA. A total of 182 patients with medial compartment osteoarthritis and treated by UKA between January 2012 and January 2017 were enrolled in this study. Computed tomography (CT) was used to measure the rotation of components. Patients were divided into two groups according to the insert design. These groups were divided into three subgroups according to the angle of the tibia relative to the femur (TFRA) (A): TFRA 0 degrees to 5 degrees either internal or external rotation; (B): TFRA >5 degrees internal rotation, and (C): TFRA >5 degrees external rotation. There was no significant difference between the groups in terms of age, body mass index (BMI) and follow-up period. KSS scores increased as the tibial component rotation (TCR) external rotation increased, but there was no correlation for WOMAC score. (P: 0,039 r: 0,207; P:0,347 r:0,095, respectively) Post-operative KSS and WOMAC scores decreased as TFRA external rotation was increased. (p: 0,001; p:0,001, respectively) No correlation has been observed between femoral component rotation (FCR) internal rotation and post-operative KSS and WOMAC scores. (p: 0,261; p: 0,502, respectively) Any mismatch between the components is better tolerated by mobile-bearing designs compared to fixed-bearing designs. Orthopedic surgeons should take care of rotational mismatch of components, not only the axial alignment of the components.Article Effects of Sensorimotor-Cognitive Training on Balance and Gait in Patients with Idiopathic Parkinson’s Disease: A Randomized Controlled Trial(Springer London Ltd, 2026) Korkusuz, Suleyman; Elibol, Bulent; Ozcan, Aysenur; Korkusuz, Busra Seckinogullari; Fil, Ayla; Cakmakli, Gul Yalcin; Yigit, OznurBackground Sensory-motor-cognitive integration deficits are common in Parkinson's disease(PD) and significantly limit functional performance, highlighting the growing need for holistic training approaches that target these domains simultaneously. Aims This study aimed to examine the effects of sensory-motor-cognitive integration training on balance and gait in patients with Parkinson's disease (PwPD). Methods A total of 40 PwPD, aged between 45 and 75 years, were included. The intervention group received 24 sessions (3 days per week for 8 weeks) of 60-minute sensory-motor-cognitive integration training. The control group was placed on a waiting list and continued their routine daily activities. All participants were assessed at baseline, at the end of the 8th week, and at the 12th week. Static posturography was used to evaluate balance [Limits of Stability and the Modified Sensory Integration and Balance Clinical Test] and gait (Walk Across test). Additionally, balance was assessed using the Functional Reach Test (FRT), and gait performance was evaluated with the Modified Dynamic Gait Index (mDGI). Results Significant time & times; group interactions were observed for functional balance and gait outcomes. The intervention group showed significant improvements in FRT and mDGI scores over time (p < 0.001), whereas no significant changes were observed in the control group. Static posturography also demonstrated significant time-related changes and group differences for most parameters (p < 0.05), except for movement velocity, directional control, and step length symmetry. Conclusion These findings suggest that individualized, multidomain sensory-motor-cognitive integration training may represent a particularly effective rehabilitation approach for enhancing balance and gait in PwPD.Article Evaluation of Central Auditory Processing in Children with Developmental Dyslexia(Elsevier Ireland Ltd, 2026) Begen, Senanur Kahraman; Ciyiltepe, Muge Muzeyyen; Arslan, BerkayObjective: Developmental dyslexia is a neurodevelopmental disorder primarily characterized by phonological and reading difficulties. This study aimed to investigate temporal auditory processing and dichotic listening performance in children with developmental dyslexia and to explore their potential contribution to reading-related difficulties. Methods: Sixty children aged 8-13 years participated in the study, including 30 children diagnosed with developmental dyslexia and 30 age-matched typically developing peers. Central auditory processing was assessed using the Staggered Spondaic Word (SSW) test for dichotic listening and the Frequency Pattern Test (FPT), Duration Pattern Test (DPT), and Random Gap Detection Test (RGDT) for temporal auditory processing. Results: Children with developmental dyslexia demonstrated significantly poorer performance than controls across all temporal and dichotic auditory processing measures (p < 0.05). In the SSW test, the greatest performance difference was observed in the left competing condition. Temporal processing deficits were evident in frequency discrimination, duration pattern recognition, and gap detection tasks. Conclusion: Children with developmental dyslexia exhibit weaknesses in temporal and dichotic auditory processing tasks. Given the linguistic demands inherent in some dichotic measures, these findings likely reflect an interaction between auditory and language-related processing rather than isolated auditory pathway dysfunction. Incorporating central auditory processing assessment into multidisciplinary dyslexia evaluations may contribute to more targeted diagnostic and intervention approaches.Article Citation - Scopus: 177Mortality Analysis of Covid-19 Infection in Chronic Kidney Disease, Haemodialysis and Renal Transplant Patients Compared With Patients Without Kidney Disease: a Nationwide Analysis From Turkey(Oxford University Press, 2021) Ozturk,S.; Turgutalp,K.; Arici,M.; Odabas,A.R.; Altiparmak,M.R.; Aydin,Z.; Ates,K.Background. Chronic kidney disease (CKD) and immunosuppression, such as in renal transplantation (RT), stand as one of the established potential risk factors for severe coronavirus disease 2019 (COVID-19). Case morbidity and mortality rates for any type of infection have always been much higher in CKD, haemodialysis (HD) and RT patients than in the general population. A large study comparing COVID-19 outcome in moderate to advanced CKD (Stages 3-5), HD and RT patients with a control group of patients is still lacking. Methods. We conducted a multicentre, retrospective, observational study, involving hospitalized adult patients with COVID-19 from 47 centres in Turkey. Patients with CKD Stages 3-5, chronic HD and RT were compared with patients who had COVID-19 but no kidney disease. Demographics, comorbidities, medications, laboratory tests, COVID-19 treatments and outcome [in-hospital mortality and combined in-hospital outcome mortality or admission to the intensive care unit (ICU)] were compared. Results. A total of 1210 patients were included [median age, 61 (quartile 1-quartile 3 48-71) years, female 551 (45.5%)] composed of four groups: Control (n = 450), HD (n = 390), RT (n = 81) and CKD (n = 289). The ICU admission rate was 266/ 1210 (22.0%). A total of 172/1210 (14.2%) patients died. The ICU admission and in-hospital mortality rates in the CKD group [114/289 (39.4%); 95% confidence interval (CI) 33.9-45.2; and 82/289 (28.4%); 95% CI 23.9-34.5)] were significantly higher than the other groups: HD = 99/390 (25.4%; 95% CI 21.3-29.9; P<0.001) and 63/390 (16.2%; 95% CI 13.0-20.4; P<0.001); RT = 17/81 (21.0%; 95% CI 13.2-30.8; P = 0.002) and 9/81 (11.1%; 95% CI 5.7-19.5; P = 0.001); and control = 36/450 (8.0%; 95% CI 5.8-10.8; P<0.001) and 18/450 (4%; 95% CI 2.5-6.2; P<0.001). Adjusted mortality and adjusted combined outcomes in CKD group and HD groups were significantly higher than the control group [hazard ratio (HR) (95% CI) CKD: 2.88 (1.52- 5.44); P = 0.001; 2.44 (1.35-4.40); P = 0.003; HD: 2.32 (1.21- 4.46); P = 0.011; 2.25 (1.23-4.12); P = 0.008), respectively], but these were not significantly different in the RT from in the control group [HR (95% CI) 1.89 (0.76-4.72); P = 0.169; 1.87 (0.81-4.28); P = 0.138, respectively]. Conclusions. Hospitalized COVID-19 patients with CKDs, including Stages 3-5 CKD, HD and RT, have significantly higher mortality than patients without kidney disease. Stages 3-5 CKD patients have an in-hospital mortality rate as much as HD patients, which may be in part because of similar age and comorbidity burden. We were unable to assess if RT patients were or were not at increased risk for in-hospital mortality because of the relatively small sample size of the RT patients in this study. © The Author(s) 2020.
