Antiproliferative Activity of Platinum(ii) and Copper(ii) Complexes Containing Novel Biquinoxaline Ligands

dc.authorid Kayi, Hakan/0000-0001-7300-0325
dc.authorid Cetin, Yuksel/0000-0001-5101-3870
dc.authorid Ozalp Yaman, Seniz/0000-0002-4166-0529
dc.authorid Elbeshti, Hager/0000-0002-3027-0859
dc.authorscopusid 58869814400
dc.authorscopusid 6506383580
dc.authorscopusid 22938517300
dc.authorscopusid 36989969700
dc.authorscopusid 8551827200
dc.authorscopusid 55372177900
dc.authorscopusid 58869793800
dc.authorwosid Kayi, Hakan/C-7300-2009
dc.authorwosid Cetin, Yuksel/AAS-7528-2020
dc.contributor.author El-Beshti, Hager Sadek
dc.contributor.author Gercek, Zuhal
dc.contributor.author Kayi, Hakan
dc.contributor.author Yildizhan, Yasemin
dc.contributor.author Cetin, Yuksel
dc.contributor.author Adiguzel, Zelal
dc.contributor.author Ozalp-Yaman, Seniz
dc.contributor.other Chemical Engineering
dc.date.accessioned 2024-07-05T15:23:33Z
dc.date.available 2024-07-05T15:23:33Z
dc.date.issued 2024
dc.department Atılım University en_US
dc.department-temp [El-Beshti, Hager Sadek; Ozalp-Yaman, Seniz] Atilim Univ, Dept Chem Engn, Ankara, Turkiye; [Gercek, Zuhal] Zonguldak Bulent Ecevit Univ, Dept Chem, Zonguldak, Turkiye; [Kayi, Hakan] Ankara Univ, Dept Chem Engn, TR-06100 Ankara, Turkiye; [Yildizhan, Yasemin; Cetin, Yuksel; Gungor, Gamze] TUBITAK, Marmara Res Ctr, Med Biotechnol Unit, Life Sci, Gebze, Kocaeli, Turkiye; [Adiguzel, Zelal] Koc Univ, Sch Med, KUTTAM, Istanbul, Turkiye; [Ozalp-Yaman, Seniz] Atilim Univ, Dept Chem Engn, TR-06836 Ankara, Turkiye en_US
dc.description Kayi, Hakan/0000-0001-7300-0325; Cetin, Yuksel/0000-0001-5101-3870; Ozalp Yaman, Seniz/0000-0002-4166-0529; Elbeshti, Hager/0000-0002-3027-0859 en_US
dc.description.abstract Nowadays, cancer represents one of the major causes of death in humans worldwide, which renders the quest for new and improved antineoplastic agents to become an urgent issue in the field of biomedicine and human health. The present research focuses on the synthesis of 2,3,2MODIFIER LETTER PRIME,3MODIFIER LETTER PRIME-tetra(pyridin-2-yl)-6,6MODIFIER LETTER PRIME-biquinoxaline) and (2,3,2MODIFIER LETTER PRIME,3MODIFIER LETTER PRIME-tetra(thiophen-2-yl)-6,6MODIFIER LETTER PRIME-biquinoxaline) containing copper(II) and platinum(II) compounds as prodrug candidates. The binding interaction of these compounds with calf thymus DNA (CT-DNA) and human serum albumin were assessed with UV titration, thermal decomposition, viscometric, and fluorometric methods. The thermodynamical parameters and the temperature-dependent binding constant (KMODIFIER LETTER PRIMEb) values point out to spontaneous interactions between the complexes and CT-DNA via the van der Waals interactions and/or hydrogen bonding, except Cu(ttbq)Cl2 for which electrostatic interaction was proposed. The antitumor activity of the complexes against several human glioblastomata, lung, breast, cervix, and prostate cell lines were investigated by examining cell viability, oxidative stress, apoptosis-terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling, in vitro migration and invasion, in vitro-comet DNA damage, and plasmid DNA interaction assays. The U87 and HeLa cells were investigated as the cancer cells most sensitive to our complexes. The exerted cytotoxic effect of complexes was attributed to the formation of the reactive oxygen species in vitro. It is clearly demonstrated that Cu(ttbq)Cl2, Pt(ttbq)Cl2, and Pt(tpbq)Cl2 have the highest DNA degradation potential and anticancer effect among the tested complexes by leading apoptosis. The wound healing and invasion analysis results also supported the higher anticancer activity of these two compounds. Graphical Abstract Antitumor activity of biqunoxaline complexes. en_US
dc.identifier.citationcount 0
dc.identifier.doi 10.1093/mtomcs/mfae001
dc.identifier.issn 1756-5901
dc.identifier.issn 1756-591X
dc.identifier.issue 2 en_US
dc.identifier.pmid 38183277
dc.identifier.scopus 2-s2.0-85184381325
dc.identifier.scopusquality Q2
dc.identifier.uri https://doi.org/10.1093/mtomcs/mfae001
dc.identifier.uri https://hdl.handle.net/20.500.14411/2331
dc.identifier.volume 16 en_US
dc.identifier.wos WOS:001157690900001
dc.identifier.wosquality Q3
dc.institutionauthor Kayı, Hakan
dc.institutionauthor Özalp Yaman, Şeniz
dc.language.iso en en_US
dc.publisher Oxford Univ Press en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 2
dc.subject Cu(II) and Pt(II) biquinoxalines en_US
dc.subject DNA/HSA binding en_US
dc.subject DNA cleavage en_US
dc.subject Apoptosis en_US
dc.subject Invasion/migration assay en_US
dc.subject ROS generation en_US
dc.title Antiproliferative Activity of Platinum(ii) and Copper(ii) Complexes Containing Novel Biquinoxaline Ligands en_US
dc.type Article en_US
dc.wos.citedbyCount 2
dspace.entity.type Publication
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