Enhancement of scaffolding properties for poly(3-hydroxybutyrate): blending with poly-β-alanine and wet electrospinning

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Date

2019

Authors

Gültan, Tuğçe
Konuk, E.
Gultan, T.
Gumusderelioglu, M.

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Taylor & Francis As

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Chemical Engineering
(2010)
Established in 2010, and aiming to train the students with the capacity to meet the demands of the 21st Century, the Chemical Engineering Department provides a sound chemistry background through intense coursework and laboratory practices, along with fundamental courses such as Physics and Mathematics within the freshman and sophomore years, following preparatory English courses.In the final two years of the program, engineering courses are offered with laboratory practice and state-of-the-art simulation programs, combining theory with practice.

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Abstract

Poly-beta-alanine (PBA), and its derivatives poly(alpha-methyl-beta-alanine) and poly[N-(3-methoxypropyl-beta-alanine) were synthesized by hydrogen transfer polymerization (HTP). Porous 3 D matrices of poly(3-hydroxybutyrate) (P3HB) reinforced with PBA/its derivatives were obtained via lyophilization and wet electrospinning. However, mechanical properties of the porous matrices prepared by wet electrospinning were found to present superior performance for tissue engineering applications. Cell culture study was performed by using wet electrospun P3HB matrices doped with 10% (w/w) PBA which show better manipulation ability, chemical and mechanical properties. Scaffolds of P3HB-PBA (10% w/w) blend was determined to demonstrate better cell attachment and proliferation compared to the scaffolds of pure P3HB.

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Keywords

Scaffold, biocompatibility, Poly-beta-alanine, Poly(3-hydroxybutyrate), cell culture, tissue engineering

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7

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Volume

68

Issue

6

Start Page

338

End Page

349

URI

https://doi.org/10.1080/00914037.2018.1552862
 https://hdl.handle.net/20.500.14411/3352

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