Risk Factors for Trabeculotomy Failure in Primary Congenital Glaucoma

dc.authorid ÜÇGÜL, Ahmet Yücel/0000-0001-9945-793X
dc.authorid Atalay, Hatice Tuba/0000-0002-1847-615X
dc.authorscopusid 20435411000
dc.authorscopusid 57204968604
dc.authorscopusid 57222165828
dc.authorscopusid 57194389838
dc.authorwosid ÜÇGÜL, Ahmet Yücel/ABH-8820-2020
dc.contributor.author Aktas, Zeynep
dc.contributor.author Ucgul, Ahmet Y.
dc.contributor.author Boluk, Ceyda E.
dc.contributor.author Atalay, Hatice T.
dc.contributor.other Surgical Sciences
dc.date.accessioned 2024-07-05T15:24:15Z
dc.date.available 2024-07-05T15:24:15Z
dc.date.issued 2022
dc.department Atılım University en_US
dc.department-temp [Aktas, Zeynep] Atilim Univ, Medicana Int Hosp, Dept Ophthalmol, Ankara, Turkey; [Aktas, Zeynep; Boluk, Ceyda E.; Atalay, Hatice T.] Gazi Univ, Dept Ophthalmol, Sch Med, Ankara, Turkey; [Ucgul, Ahmet Y.] Ahi Evran Univ, Training & Res Hosp, Dept Ophthalmol, Kirsehir, Turkey; [Aktas, Zeynep] 172 Sok Bahcelievler Mah Safak Sitesi,4 Golbasi, Ankara, Turkey en_US
dc.description ÜÇGÜL, Ahmet Yücel/0000-0001-9945-793X; Atalay, Hatice Tuba/0000-0002-1847-615X en_US
dc.description.abstract Precis:This study demonstrates that a baseline corneal diameter >12.25, initial age <4 months at diagnosis, higher baseline IOP than 24 mm Hg, bilaterality, or inability to perform circumferential trabeculotomy, increases the risk of surgical failure of trabeculotomy in patients with primary congenital glaucoma (PCG). Purpose:The aim of this study was to identify clinical predictive factors for surgical failure and to evaluate potential prognostic factors affecting surgical success in patients with PCG who underwent trabeculotomy. Patients and Methods:The medical charts of 123 eyes of 75 patients who underwent trabeculotomy surgery for the treatment of PCG were retrospectively reviewed. At baseline and each visit, intraocular pressure (IOP), corneal diameter, cup to disc ratio, axial length, number of medications, and need for further glaucoma surgery were noted. Surgical success was defined as an IOP <= 18 mm Hg and 20% IOP reduction from baseline with (qualified) or without (complete) medication and without any further IOP-lowering surgery. Results:The mean age at surgery was 4.2 +/- 6.6 months and the mean follow-up time was 60.0 +/- 37.6 months. The receiver operating characteristic curve showed 4 following best cutoff values to predict surgical failure: the first for age at surgery was 4.5 months; the second baseline IOP was 24.0 mm Hg; the third for baseline cup to disc ratio was 0.4; and the fourth for baseline corneal diameter was 12.25 mm. Multivariate logistic regression analysis revealed that baseline IOP more than 24 mm Hg increased the risk of surgical failure by 2 times, baseline mean corneal diameter >12.25 mm did by 4.2 times, younger age than 4 months did by 2.5 times, bilaterality did by 1.5 times. Conclusions:A higher baseline IOP, younger age, larger corneal diameter, and bilaterality were identified as risk factors for trabeculotomy failure in congenital glaucoma. The presence of one or more of these should be considered in the decision-making process when considering surgical options to manage glaucoma in these patients. en_US
dc.identifier.citationcount 1
dc.identifier.doi 10.1097/IJG.0000000000002098
dc.identifier.endpage 971 en_US
dc.identifier.issn 1057-0829
dc.identifier.issn 1536-481X
dc.identifier.issue 12 en_US
dc.identifier.pmid 35980847
dc.identifier.scopus 2-s2.0-85143180032
dc.identifier.scopusquality Q2
dc.identifier.startpage 966 en_US
dc.identifier.uri https://doi.org/10.1097/IJG.0000000000002098
dc.identifier.uri https://hdl.handle.net/20.500.14411/2413
dc.identifier.volume 31 en_US
dc.identifier.wos WOS:000920329000010
dc.identifier.wosquality Q3
dc.institutionauthor Aktaş, Zeynep
dc.language.iso en en_US
dc.publisher Lippincott Williams & Wilkins en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 3
dc.subject clinical predictors en_US
dc.subject primary congenital glaucoma en_US
dc.subject trabeculotomy failure en_US
dc.title Risk Factors for Trabeculotomy Failure in Primary Congenital Glaucoma en_US
dc.type Article en_US
dc.wos.citedbyCount 3
dspace.entity.type Publication
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