Comparison of Amiodarone Loading Dosage in the Treatment of Postoperative Atrial Fibrillation: High Versus Standard Dose Treatment

dc.authorscopusid15840456000
dc.authorscopusid15840074700
dc.authorscopusid56105521000
dc.authorscopusid7003971982
dc.authorscopusid56157187300
dc.authorscopusid57428018900
dc.authorwosidCantekin, Ömer Faruk/AHE-6254-2022
dc.contributor.authorSarıçam, E.
dc.contributor.authorÖcal, A.
dc.contributor.authorIscanlı, M.D.
dc.contributor.authorBozkurt, E.
dc.contributor.authorIlkay, E.
dc.contributor.authorCantekin, ÖF.
dc.date.accessioned2024-10-06T10:58:48Z
dc.date.available2024-10-06T10:58:48Z
dc.date.issued2024
dc.departmentAtılım Universityen_US
dc.department-tempSarıçam E., Cardiology Clinic, Medicana International Ankara Hospital, Atilim University, Ankara, Turkey; Öcal A., Cardiology Clinic, Saglik Bilimleri University, Gülhane Eğitim ve Araştırma Hastanesi, Ankara, Turkey; Iscanlı M.D., Emergency Department, Medicana International Ankara Hospital, Atilim University, Ankara, Turkey; Bozkurt E., Cardiology Clinic, Medicana International Ankara Hospital, Ankara, Turkey; Ilkay E., Medicana International Ankara Hospital, Cardiology Clinic, Ankara, Turkey; Cantekin ÖF., Department of Social Work, Faculty of Health Sciences, Gazi University, Ankara, Turkeyen_US
dc.description.abstractBACKGROUND: Postoperative atrial fibrillation (POAF) is associated with poor outcomes, including hemodynamic instability, stroke, myocardial infarction, and death. In hemodynamic stable patients, the rhythm-control strategy is more advantageous than rate control. Current standard intravenous amiodarone administration has limited success and a delayed effect; the acute success rate is 44% (8-12 h to several days). PURPOSE: The aim of this study was to evaluate the effectiveness of higher amiodarone loading dosage to restore sinus rhythm in patients with POAF after noncardiac surgery. METHODS: This is a prospective, randomized, controlled single-center study. The study included 39 patients with POAF, divided into group I (n=27) (intravenous 600 mg amiodarone loading dosage over 2 h and infusion of 50 mg/h over a 24-h period) and group II (n=12) (standard protocol; 300 mg of bolus intravenously in 30 min and infusion of 50 mg/h over a 24-h period). The primary endpoint of the study was a restoration of sinus rhythm at the 24th hour. RESULTS: Baseline clinical, laboratory and echocardiographic characteristics of both groups were similar. The patients with higher loading amiodarone dosage had earlier restoration of sinus rhythm (2.38 ± 1.41 vs 8.66 ± 2.87 h, respectively; p=0.015). There was no significant difference in achieving sinus rhythm at the 24th hour between both groups. CONCLUSION: Higher loading amiodarone dosage increased early conversions to sinus rhythm compared with standard amiodarone protocol in patients with POAF. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.en_US
dc.description.woscitationindexScience Citation Index Expanded
dc.identifier.citationcount0
dc.identifier.doi10.2174/0115701611259127231208051249
dc.identifier.endpage390en_US
dc.identifier.issn1875-6212
dc.identifier.issue6en_US
dc.identifier.pmid39219115
dc.identifier.scopus2-s2.0-85208771792
dc.identifier.scopusqualityQ1
dc.identifier.startpage386en_US
dc.identifier.urihttps://doi.org/10.2174/0115701611259127231208051249
dc.identifier.volume22en_US
dc.identifier.wosWOS:001308379300001
dc.identifier.wosqualityQ2
dc.institutionauthorSarıçam, Ersin
dc.institutionauthorİşcanlı, Murat Doğan
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCurrent vascular pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.scopus.citedbyCount0
dc.subjectAmiodaroneen_US
dc.subjectdosageen_US
dc.subjectechocardiographic.en_US
dc.subjectlaboratoryen_US
dc.subjectpostoperative atrial fibrillationen_US
dc.subjectsinus rhythmen_US
dc.titleComparison of Amiodarone Loading Dosage in the Treatment of Postoperative Atrial Fibrillation: High Versus Standard Dose Treatmenten_US
dc.typeArticleen_US
dc.wos.citedbyCount0
dspace.entity.typePublication
relation.isAuthorOfPublication52f1c80b-bfc2-4b0d-9cc1-1bc202293ff7
relation.isAuthorOfPublication43e41140-c776-4f23-8f6c-1810ae2535bf
relation.isAuthorOfPublication.latestForDiscovery52f1c80b-bfc2-4b0d-9cc1-1bc202293ff7

Files

Collections