Comparison of Amiodarone Loading Dosage in the Treatment of Postoperative Atrial Fibrillation: High Versus Standard Dose Treatment
dc.authorscopusid | 15840456000 | |
dc.authorscopusid | 15840074700 | |
dc.authorscopusid | 56105521000 | |
dc.authorscopusid | 7003971982 | |
dc.authorscopusid | 56157187300 | |
dc.authorscopusid | 57428018900 | |
dc.authorwosid | Cantekin, Ömer Faruk/AHE-6254-2022 | |
dc.contributor.author | Sarıçam, E. | |
dc.contributor.author | Öcal, A. | |
dc.contributor.author | Iscanlı, M.D. | |
dc.contributor.author | Bozkurt, E. | |
dc.contributor.author | Ilkay, E. | |
dc.contributor.author | Cantekin, ÖF. | |
dc.date.accessioned | 2024-10-06T10:58:48Z | |
dc.date.available | 2024-10-06T10:58:48Z | |
dc.date.issued | 2024 | |
dc.department | Atılım University | en_US |
dc.department-temp | Sarıçam E., Cardiology Clinic, Medicana International Ankara Hospital, Atilim University, Ankara, Turkey; Öcal A., Cardiology Clinic, Saglik Bilimleri University, Gülhane Eğitim ve Araştırma Hastanesi, Ankara, Turkey; Iscanlı M.D., Emergency Department, Medicana International Ankara Hospital, Atilim University, Ankara, Turkey; Bozkurt E., Cardiology Clinic, Medicana International Ankara Hospital, Ankara, Turkey; Ilkay E., Medicana International Ankara Hospital, Cardiology Clinic, Ankara, Turkey; Cantekin ÖF., Department of Social Work, Faculty of Health Sciences, Gazi University, Ankara, Turkey | en_US |
dc.description.abstract | BACKGROUND: Postoperative atrial fibrillation (POAF) is associated with poor outcomes, including hemodynamic instability, stroke, myocardial infarction, and death. In hemodynamic stable patients, the rhythm-control strategy is more advantageous than rate control. Current standard intravenous amiodarone administration has limited success and a delayed effect; the acute success rate is 44% (8-12 h to several days). PURPOSE: The aim of this study was to evaluate the effectiveness of higher amiodarone loading dosage to restore sinus rhythm in patients with POAF after noncardiac surgery. METHODS: This is a prospective, randomized, controlled single-center study. The study included 39 patients with POAF, divided into group I (n=27) (intravenous 600 mg amiodarone loading dosage over 2 h and infusion of 50 mg/h over a 24-h period) and group II (n=12) (standard protocol; 300 mg of bolus intravenously in 30 min and infusion of 50 mg/h over a 24-h period). The primary endpoint of the study was a restoration of sinus rhythm at the 24th hour. RESULTS: Baseline clinical, laboratory and echocardiographic characteristics of both groups were similar. The patients with higher loading amiodarone dosage had earlier restoration of sinus rhythm (2.38 ± 1.41 vs 8.66 ± 2.87 h, respectively; p=0.015). There was no significant difference in achieving sinus rhythm at the 24th hour between both groups. CONCLUSION: Higher loading amiodarone dosage increased early conversions to sinus rhythm compared with standard amiodarone protocol in patients with POAF. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. | en_US |
dc.description.woscitationindex | Science Citation Index Expanded | |
dc.identifier.citationcount | 0 | |
dc.identifier.doi | 10.2174/0115701611259127231208051249 | |
dc.identifier.endpage | 390 | en_US |
dc.identifier.issn | 1875-6212 | |
dc.identifier.issue | 6 | en_US |
dc.identifier.pmid | 39219115 | |
dc.identifier.scopus | 2-s2.0-85208771792 | |
dc.identifier.scopusquality | Q1 | |
dc.identifier.startpage | 386 | en_US |
dc.identifier.uri | https://doi.org/10.2174/0115701611259127231208051249 | |
dc.identifier.volume | 22 | en_US |
dc.identifier.wos | WOS:001308379300001 | |
dc.identifier.wosquality | Q2 | |
dc.institutionauthor | Sarıçam, Ersin | |
dc.institutionauthor | İşcanlı, Murat Doğan | |
dc.language.iso | en | en_US |
dc.publisher | Bentham Science Publ Ltd | en_US |
dc.relation.ispartof | Current vascular pharmacology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.scopus.citedbyCount | 0 | |
dc.subject | Amiodarone | en_US |
dc.subject | dosage | en_US |
dc.subject | echocardiographic. | en_US |
dc.subject | laboratory | en_US |
dc.subject | postoperative atrial fibrillation | en_US |
dc.subject | sinus rhythm | en_US |
dc.title | Comparison of Amiodarone Loading Dosage in the Treatment of Postoperative Atrial Fibrillation: High Versus Standard Dose Treatment | en_US |
dc.type | Article | en_US |
dc.wos.citedbyCount | 0 | |
dspace.entity.type | Publication | |
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relation.isAuthorOfPublication | 43e41140-c776-4f23-8f6c-1810ae2535bf | |
relation.isAuthorOfPublication.latestForDiscovery | 52f1c80b-bfc2-4b0d-9cc1-1bc202293ff7 |