A Novel Treatment Strategy for Preterm Birth: Intra-Vaginal Progesterone-Loaded Fibrous Patches

dc.authorid Cam, Muhammet Emin/0000-0001-5398-6801
dc.authorid Gunduz, Oguzhan/0000-0002-4926-6489
dc.authorid Brako, Francis/0000-0002-1163-1874
dc.authorid Ren, Guogang/0000-0001-8865-1526
dc.authorid Turkoglu Sasmazel, Hilal/0000-0002-0254-4541
dc.authorid Ozkan, Ozan/0000-0002-9050-1583
dc.authorid Alenezi, Hussain/0000-0003-4563-7868
dc.authorscopusid 57196054486
dc.authorscopusid 57200390634
dc.authorscopusid 57210993204
dc.authorscopusid 57189848353
dc.authorscopusid 57211350417
dc.authorscopusid 16680382000
dc.authorscopusid 12797373800
dc.authorwosid Cam, Muhammet Emin/AAB-4488-2019
dc.authorwosid Kabasakal, Levent/E-3503-2019
dc.authorwosid Gunduz, Oguzhan/AAA-3212-2019
dc.authorwosid Brako, Francis/HTO-1755-2023
dc.authorwosid Ren, Guogang/P-4540-2017
dc.authorwosid Gunduz, Oguzhan/E-5292-2011
dc.contributor.author Cam, Muhammet Emin
dc.contributor.author Hazar-Yavuz, Ayse Nur
dc.contributor.author Cesur, Sumeyye
dc.contributor.author Ozkan, Ozan
dc.contributor.author Alenezi, Hussain
dc.contributor.author Sasmazel, Hilal Turkoglu
dc.contributor.author Edirisinghe, Mohan
dc.contributor.other Metallurgical and Materials Engineering
dc.date.accessioned 2024-07-05T15:39:05Z
dc.date.available 2024-07-05T15:39:05Z
dc.date.issued 2020
dc.department Atılım University en_US
dc.department-temp [Cam, Muhammet Emin; Alenezi, Hussain; Brako, Francis; Ahmed, Jubair; Edirisinghe, Mohan] UCL, Dept Mech Engn, Torrington Pl, London WC1E 7JE, England; [Cam, Muhammet Emin; Cesur, Sumeyye; Gunduz, Oguzhan] Marmara Univ, Ctr Nanotechnol & Biomat Applicat & Res, TR-34722 Istanbul, Turkey; [Cam, Muhammet Emin; Hazar-Yavuz, Ayse Nur; Kabasakal, Levent] Marmara Univ, Dept Pharmacol, Fac Pharm, TR-34668 Istanbul, Turkey; [Cesur, Sumeyye; Gunduz, Oguzhan] Marmara Univ, Dept Met & Mat Engn, Fac Technol, TR-34722 Istanbul, Turkey; [Ozkan, Ozan; Sasmazel, Hilal Turkoglu] Atilim Univ, Dept Met & Mat Engn, Fac Engn, TR-06836 Ankara, Turkey; [Alenezi, Hussain] PAAET, Dept Mfg Engn, Coll Technol Studies, Kuwait 13092, Kuwait; [Eroglu, Mehmet Sayip] Marmara Univ, Dept Chem Engn, Fac Engn, Goztepe Campus, TR-34722 Kadikoy, Turkey; [Eroglu, Mehmet Sayip] TUBITAK UME, Chem Grp Labs, TR-41470 Gebze, Turkey; [Brako, Francis] UCL, Sch Pharm, 29-39 Brunswick Sq, London WC1N 1AX, England; [Ren, Guogang] Univ Hertfordshire, Sch Engn & Technol, Mech & Mech Engn Div, Hatfield, Herts, England en_US
dc.description Cam, Muhammet Emin/0000-0001-5398-6801; Gunduz, Oguzhan/0000-0002-4926-6489; Brako, Francis/0000-0002-1163-1874; Ren, Guogang/0000-0001-8865-1526; Turkoglu Sasmazel, Hilal/0000-0002-0254-4541; Ozkan, Ozan/0000-0002-9050-1583; Gunduz, Oguzhan/0000-0002-9427-7574; Alenezi, Hussain/0000-0003-4563-7868 en_US
dc.description.abstract Progesterone-loaded poly(lactic) acid fibrous polymeric patches were produced using electrospinning and pressurized gyration for infra-vaginal application to prevent preterm birth. The patches were intravaginally inserted into rats in the final week of their pregnancy, equivalent to the third trimester of human pregnancy. Maintenance tocolysis with progesterone-loaded patches was elucidated by recording the contractile response of uterine smooth muscle to noradrenaline in pregnant rats. Both progesterone-loaded patches indicated similar results from release and thermal studies, however, patches obtained by electrospinning had smaller average diameters and more uniform dispersion compared to pressurized gyration. Patches obtained by pressurized gyration had better results in production yield and tensile strength than electrospinning; thereby pressurized gyration is better suited for scaled-up production. The patches did not affect cell attachment, viability, and proliferation on Vero cells negatively. Consequently, progesterone-loaded patches are a novel and successful treatment strategy for preventing preterm birth. en_US
dc.description.sponsorship UK Engineering & Physical Sciences Research Council (EPSRC) [EP/S016872/1, EP/N034228/1]; TUBITAK 2219 Research Programme Grant (Scientific and Technological Research Council of Turkey-TUBITAK) [1059B191800800]; EPSRC [EP/S016872/1, EP/N034228/1, EP/N034368/1] Funding Source: UKRI en_US
dc.description.sponsorship The authors are grateful to the UK Engineering & Physical Sciences Research Council (EPSRC) for funding pressurized gyration forming research at University College London (Grants EP/S016872/1 and EP/N034228/1). Dr. M.E. Cam was supported by a TUBITAK 2219 Research Programme Grant (Scientific and Technological Research Council of Turkey-TUBITAK, Grant Number: 1059B191800800) and thanks UCL Mechanical Engineering for hosting his post-doctoral research in the UK. en_US
dc.identifier.citationcount 31
dc.identifier.doi 10.1016/j.ijpharm.2020.119782
dc.identifier.issn 0378-5173
dc.identifier.issn 1873-3476
dc.identifier.pmid 32822780
dc.identifier.scopus 2-s2.0-85089830531
dc.identifier.uri https://doi.org/10.1016/j.ijpharm.2020.119782
dc.identifier.uri https://hdl.handle.net/20.500.14411/3169
dc.identifier.volume 588 en_US
dc.identifier.wos WOS:000576740600005
dc.identifier.wosquality Q1
dc.institutionauthor Özkan, Ozan
dc.institutionauthor Şaşmazel, Hilal Türkoğlu
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 43
dc.subject Progesterone en_US
dc.subject Pressurized gyration en_US
dc.subject Electrospinning en_US
dc.subject Fibers en_US
dc.subject Polymeric patch en_US
dc.subject Preterm birth en_US
dc.title A Novel Treatment Strategy for Preterm Birth: Intra-Vaginal Progesterone-Loaded Fibrous Patches en_US
dc.type Article en_US
dc.wos.citedbyCount 38
dspace.entity.type Publication
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